Serial Intervals and Household Transmission of SARS-CoV-2 Omicron Variant, South Korea, 2021

Song, Jin Su; Lee, Ji Hee; Kim, Miyoung; Jeong, Hyeong Seop; Kim, Moon Su; Kim, Seong‐Gon; Yoo, Han Na; Lee, Ji Joo; Lee, Hye Young; Lee, Sang-Eun; Kim, Eun Jin; Rhee, Jee Eun; Kim, Il Hwan; Park, Young-Joon

doi:10.3201/eid2803.212607

Cited by 62 publications

(65 citation statements)

References 6 publications

(5 reference statements)

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“…Omicron infection resulted in high ARs among household contacts in this investigation, particularly among those who lived with index patients who were not vaccinated or who did not practice prevention measures (isolating or ever wearing a mask at home). The estimated overall AR in this investigation is consistent with the range of ARs observed in other Omicron transmission studies †††† ( 3 ), and higher than those associated with some other SARS-CoV-2 variants. §§§§ These findings underscore the importance of implementation of multicomponent prevention measures for reducing SARS-CoV-2 transmission in household settings, including from the Omicron variant ( 4 ).…”

Section: Discussionsupporting

confidence: 88%

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SARS-CoV-2 B.1.1.529 (Omicron) Variant Transmission Within Households — Four U.S. Jurisdictions, November 2021–February 2022

Baker¹,

Nakayama²,

O’Hegarty³

et al. 2022

MMWR Morb. Mortal. Wkly. Rep.

120

123

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In this investigation, a confirmed case in a household contact was defined as having received a positive SARS-CoV-2 nucleic acid amplification test result or antigen test result ≤14 days after the index date (date of the index patient's symptom onset or positive SARS-CoV-2 nucleic acid amplification test result or antigen test result), and a probable case in a household contact was defined as the presence of COVID-19-compatible symptoms during the same 14-day period but without a positive SARS-CoV-2 test confirmation. Persons without symptoms and who did not have a positive SARS-CoV-2 test result were not considered to have a case of COVID-19. Analysis of AR among household contacts excluded eight persons with unknown case status (persons for whom it was not known whether COVID-19-compatible symptoms were present and whether SARS-CoV-2 testing had occurred [or if testing occurred, the results were unknown]).

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Section: Discussionsupporting

confidence: 88%

“…CDC COVID-19 Emergency Response Team; 2 Epidemic Intelligence Service, CDC;3 Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee;4 Chicago Department of Public Health;5 Connecticut Department of Public Health; 6 Milwaukee Health Department; 7 Utah Department of Health; 8 CDC Foundation, Atlanta, Georgia.…”

mentioning

confidence: 99%

SARS-CoV-2 B.1.1.529 (Omicron) Variant Transmission Within Households — Four U.S. Jurisdictions, November 2021–February 2022

Baker¹,

Nakayama²,

O’Hegarty³

et al. 2022

MMWR Morb. Mortal. Wkly. Rep.

120

123

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“…Soon after, our data show a rapid increase in the population level exposure to SARS-CoV-2. This indicates a high transmission rate and is in line with previous reports from elsewhere [4,5,6]. At the end of the study period (week 9/2022), 4% were seronegative in N and S antibody testing.…”

supporting

confidence: 91%

Rapid increase in SARS-CoV-2 seroprevalence during the emergence of Omicron variant, Finland

Ahava

Jarva

Jääskeläinen

et al. 2022

Preprint

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Objectives The aim of this study was to assess changes in exposure and prevalence of SARS-CoV-2 infection during the first months of emergence of Omicron variant in the Greater Helsinki area, Finland. Methods A prospective seroepidemiological survey of SARS-CoV-2 was conducted on 1,600 serum specimens sent to Helsinki University Hospital Laboratory (HUSLAB) for HIV serology between 15 November 2021 and 6 March 2022 (calendar weeks 46/2021 - 9/2022). For each calendar week, 100 serum specimens were randomly selected and analysed for SARS-CoV-2 IgG antibodies against nucleocapsid (N) and spike 1 (S1) protein with Abbott SARS-CoV-2 IgG (N protein) and SARS-CoV-2 IgG II Quant (S protein) tests, respectively. Results The prevalence of N antibodies increased from 5.2% (weeks 46-50/2021) to 28.2% (weeks 5-9/2022) during the study period. The proportion of seronegative samples as well as anti-N negative, anti-S1 positive samples decreased correspondingly from 11.6% to 3.8%, and 84.2% to 68.2%, respectively. Anti-N positive samples that were anti-S1 negative only began to appear as of week 2/2022. Conclusions A rapid increase in the N antibody prevalence was observed over the study period, suggesting a high transmission rate. A substantial proportion of COVID-19 cases remained undiagnosed during the emergence of Omicron variant in the Greater Helsinki Area, Finland.

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“…The omicron variant of SARS-CoV-2 has a shorter incubation period and substantially higher transmission rates than prior variants, dwarfing preceding variants in globally reported cases 1-3 . Recently, public health guidance has recommended shortening the strict isolation period in non-health care settings from 10 to 5 days after symptom onset or the initial positive test 4 .…”

Section: Mainmentioning

confidence: 93%

Duration of viable virus shedding in SARS-CoV-2 omicron variant infection

Boucau

Marino

Regan

et al. 2022

Preprint

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Clinical features of SARS-CoV-2 Omicron variant infection, including incubation period and transmission rates, distinguish this variant from preceding variants. However, whether the duration of shedding of viable virus differs between omicron and previous variants is not well understood. To characterize how variant and vaccination status impact shedding of viable virus, we serially sampled symptomatic outpatients newly diagnosed with COVID-19. Anterior nasal swabs were tested for viral load, sequencing, and viral culture. Time to PCR conversion was similar between individuals infected with the Delta and the Omicron variant. Time to culture conversion was also similar, with a median time to culture conversion of 6 days (interquartile range 4-8 days) in both groups. There were also no differences in time to PCR or culture conversion by vaccination status.

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Serial Intervals and Household Transmission of SARS-CoV-2 Omicron Variant, South Korea, 2021

Cited by 62 publications

References 6 publications

SARS-CoV-2 B.1.1.529 (Omicron) Variant Transmission Within Households — Four U.S. Jurisdictions, November 2021–February 2022

SARS-CoV-2 B.1.1.529 (Omicron) Variant Transmission Within Households — Four U.S. Jurisdictions, November 2021–February 2022

Rapid increase in SARS-CoV-2 seroprevalence during the emergence of Omicron variant, Finland

Duration of viable virus shedding in SARS-CoV-2 omicron variant infection

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