Serial heart rhythm complexity changes in patients with anterior wall ST segment elevation myocardial infarction

Abstract

Heart rhythm complexity analysis has been shown to have good prognostic power in patients with cardiovascular disease. The aim of this study was to analyze serial changes in heart rhythm complexity from the acute to chronic phase of acute myocardial infarction (MI). We prospectively enrolled 27 patients with anterior wall ST segment elevation myocardial infarction (STEMI) and 42 control subjects. In detrended fluctuation analysis (DFA), the patients had significantly lower DFAα2 in the acute stage (within 72 hours) and lower DFAα1 at 3 months and 12 months after MI. In multiscale entropy (MSE) analysis, the patients had a lower slope 5 in the acute stage, which then gradually increased during the follow-up period. The areas under the MSE curves for scale 1 to 5 (area 1–5) and 6 to 20 (area 6–20) were lower throughout the chronic stage. Area 6–20 had the greatest discriminatory power to differentiate the post-MI patients (at 1 year) from the controls. In both the net reclassification improvement and integrated discrimination improvement models, MSE parameters significantly improved the discriminatory power of the linear parameters to differentiate the post-MI patients from the controls. In conclusion, the patients with STEMI had serial changes in cardiac complexity.

Usefulness of heart rhythm complexity in heart failure detection and diagnosis

“…However, previous HRV studies have mainly focused on linear analysis, and its ability to predict outcomes remains limited compared with non-linear HRV 8,12 . Non-linear HRV has also been studied with regards to the diagnosis and outcome prediction in many diseases with excellent results, including the outcomes of acute stroke 34 , primary aldosteronism 16 , severity of abdominal aorta calcification 35 , critical illnesses requiring extracorporeal life support 36 , post-myocardial infarction heart function 37 , and pulmonary hypertension 17 .…”

The association between heart rhythm complexity and the severity of abdominal aorta calcification in peritoneal dialysis patients

“…The non-linear analysis of HRV including MSE and DFA has been reported to be a better predictor of clinical outcomes than traditional linear analysis. MSE has been associated with the prognosis of heart failure 13 , outcome of acute stroke 41 , primary aldosteronism 42 , critical illnesses requiring extracorporeal life support 43 , and post-myocardial infarction heart function 44 . Furthermore, long-time scale parameters (area 6–20) in heart failure patients have been shown to have the best prognostic predictive power 13 , which is similar to our MSE results.…”

Performance Evaluation of an Entropy-Based Structural Health Monitoring System Utilizing Composite Multiscale Cross-Sample Entropy

“…Inspired by a series of biomedical studies that have used the area of the MSE curve as an index for quantifying complexity [ 27 , 28 , 29 ], the DI was proposed as a measure for rapidly and efficiently diagnosing the floor damage of a structure. Signals are considered more complex when their entropy values are higher than those of other signals.…”