Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis

Wenning, Christian; Kloth, Christopher; Kuhlmann, Michael; Schober, Otmar; Hermann, Sven; Schäfers, Michael

doi:10.1016/j.atherosclerosis.2014.03.008

Cited by 29 publications

(26 citation statements)

References 18 publications

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“…Hypoxia is a prominent feature of the atherosclerotic milieu and associates strongly with the burden of macrophage infiltration and inflammation (41). Animal (42)(43)(44)(45)(46)(47)(48) and human (33,(49)(50)(51) studies have consistently demonstrated a correlation between 18 F-FDG uptake and the presence and density of macrophages in atherosclerosis. 18 F-FDG PET vascular imaging in humans was first described in 1999 in Takayasu's arteritis, before being investigated in other vasculitides (52)(53)(54).…”

Section: F-fdg Detection Of Vascular Inflammationmentioning

confidence: 99%

Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with 18F positron emission tomography

Scherer

Psaltis

2016

Cardiovasc. Diagn. Ther.

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Atherosclerosis is characterized by the formation of complex atheroma lesions (plaques) in arteries that pose risk by their flow-limiting nature and propensity for rupture and thrombotic occlusion.It develops in the context of disturbances to lipid metabolism and immune response, with inflammation underpinning all stages of plaque formation, progression and rupture. As the primary disease process responsible for myocardial infarction, stroke and peripheral vascular disease, atherosclerosis is a leading cause of morbidity and mortality on a global scale. A precise understanding of its pathogenic mechanisms is therefore critically important. Integral to this is the role of vascular wall imaging. Over recent years, the rapidly evolving field of molecular imaging has begun to revolutionize our ability to image beyond just the anatomical substrate of vascular disease, and more dynamically assess its pathobiology. Nuclear imaging by positron emission tomography (PET) can target specific molecular and biological pathways involved in atherosclerosis, with the application of 18 Fluoride PET imaging being widely studied for its potential to identify plaques that are vulnerable or high risk. In this review, we discuss the emergence of 18 Fluoride PET as a promising modality for the assessment of coronary atherosclerosis, focusing on the strengths and limitations of the two main radionuclide tracers that have been investigated to date: 2-deoxy-2-(

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Section: F-fdg Detection Of Vascular Inflammationmentioning

confidence: 99%

Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with 18F positron emission tomography

Scherer

Psaltis

2016

Cardiovasc. Diagn. Ther.

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“…Similar but less pronounced diff erences were observed when segmental F- 18-FDG accumulation normalized to blood radioactivity was assessed. In an experimental model in mice producing infl amed plaques upstream and stable plaques downstream of an implanted device, it was claimed that F-18-FDG can be used to diff erentiate between plaques with infl ammation versus phenotypically stable ones [9]. The in vivo PET imaging, however, revealed no signifi cant diff erence in the targetbackground ratio between these segments.…”

Section: Experimental Modelsmentioning

confidence: 96%

Molecular imaging of atherosclerotic lesions by positron emission tomography - can it meet the expectations?

Brammen

Steiner

Berent³

et al. 2016

Vasa

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Summary:Early non-invasive imaging of atherosclerosis and in particular the detection of lesions at risk with high specifi city could significantly affect cardiovascular morbidity and mortality. Conventional nuclear medicine approaches, in particular using autologous radiolabeled lipoproteins, can be related to histopathological fi ndings; however, they fail to identify lesions at risk. Positron emission tomography (PET) tracers with much better physical properties have been examined, the most detailed information being available for F-18-deoxyglucose (FDG) and F-18-sodium fl uoride (NaF). These two approaches are sensitive to different biochemical mechanisms, i.e. infl ammation and microcalcifi cation. Initial enthusiasm, in particular for F-18-FDG, has disappeared, although for F-18-NaF there is some hope, but this is not a breakthrough. No tracer is available so far that is able to identify a specifi c characteristic of a lesion prone to rupture. Other PET tracers in the pipeline have been examined, mainly in experimental models and only a few in patients, but they failed to contribute signifi cantly to early lesion discovery and do not support great expectations. The key question is: Do we understand what we see? Moreover, methodological problems, a lack of standardization of imaging protocols and aspects of quantifi cation provide a wide range for potential future improvements. While monitoring a therapeutic intervention seems to be possible for both F-18-FDG and F-18-NaF, highly specifi c early identifi cation of lesions at risk by PET imaging is still far away. As of today, PET is not ready for routine clinical judgment of atherosclerotic lesions at risk to rupture. Even if all these problems can be solved, radiation exposure will still remain a concern, in particular for repeated studies.

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“…For example, Uppal et al [45] combined TOF-MRA and a fibrin-specific contrast agent to simultaneously image fluid flow and plaque formation in the brain (Figure 6B–E). Other groups have targeted fibrin with peptide chains, such as 111 In-labeled EPeP and FibPep, which serve as tracers for SPECT/CT imaging [81,158,159]. These magnetic nanoclusters serve as negative MR contrast agents, though their tendency to cluster and inability to degrade are barriers to clinical translation.…”

Section: Carotid and Cerebrovascular Diseasementioning

confidence: 99%

“…One such method, fluorescence molecular tomography [223], can be used to detect macrophages [224,225] and adhesion molecules within murine plaques [226]. Others have used targeted nanoparticles to image plaques and thrombi using fibrin-binding peptides [81,158,159], smart fluorescent probes that fluoresce upon interaction with proteases [223], and ultrasound-guided echogenic liposomes [227,228]. Additionally, novel dendritic nanoprobes improve PET imaging of ischemic hind-limb mice due to enhanced bioavailability, affinity, and radiostability [229].…”

Section: Emerging Technologies and Future Directionsmentioning

confidence: 99%

Imaging of Small Animal Peripheral Artery Disease Models: Recent Advancements and Translational Potential

Lin

Phillips

Riggins

et al. 2015

IJMS

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Peripheral artery disease (PAD) is a broad disorder encompassing multiple forms of arterial disease outside of the heart. As such, PAD development is a multifactorial process with a variety of manifestations. For example, aneurysms are pathological expansions of an artery that can lead to rupture, while ischemic atherosclerosis reduces blood flow, increasing the risk of claudication, poor wound healing, limb amputation, and stroke. Current PAD treatment is often ineffective or associated with serious risks, largely because these disorders are commonly undiagnosed or misdiagnosed. Active areas of research are focused on detecting and characterizing deleterious arterial changes at early stages using non-invasive imaging strategies, such as ultrasound, as well as emerging technologies like photoacoustic imaging. Earlier disease detection and characterization could improve interventional strategies, leading to better prognosis in PAD patients. While rodents are being used to investigate PAD pathophysiology, imaging of these animal models has been underutilized. This review focuses on structural and molecular information and disease progression revealed by recent imaging efforts of aortic, cerebral, and peripheral vascular disease models in mice, rats, and rabbits. Effective translation to humans involves better understanding of underlying PAD pathophysiology to develop novel therapeutics and apply non-invasive imaging techniques in the clinic.

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Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis

Cited by 29 publications

References 18 publications

Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with 18F positron emission tomography

Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with 18F positron emission tomography

Molecular imaging of atherosclerotic lesions by positron emission tomography - can it meet the expectations?

Imaging of Small Animal Peripheral Artery Disease Models: Recent Advancements and Translational Potential

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