Serial Excision of Facial Hemangiomas

Kulbersh, Jonathan S.; Hochman, Marcelo

doi:10.1001/archfacial.2011.23

Cited by 9 publications

(2 citation statements)

References 9 publications

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“…The pooled OR for effectiveness was 0.55 (95%CI, 0.43–0.67; P heterogeneity = 0.0001; I 2 = 77.8%). In addition, the OR was 0.56 (95%CI, 0.50–0.61; P heterogeneity < 0.0001; I 2 = 88.9%) for the effectiveness of other beta-adrenergic blockers [ 67 – 73 ] and 0.55 (95%CI, 0.28–0.81; P heterogeneity = 0.0159; I 2 = 82.8%) for the effectiveness of surgery [ 65 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Oral Propranolol versus Other Treatments for Infantile Hemangiomas: A Meta-Analysis

Liu

Zheng

et al. 2015

PLoS ONE

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BackgroundEpidemiological studies evaluating treatments for infantile hemangiomas have produced inconsistent results. A meta-analysis of published data was conducted to investigate the effectiveness and safety of oral propranolol versus other treatments for infantile hemangiomas.MethodsA meta-analysis was conducted based on literature (published from 1960 to December 1, 2014) found on the PubMed, EMBASE, and OVID search engines. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the outcome measures. Heterogeneity, publication bias and subgroup analysis were performed.ResultsA total of 61 studies involving 5,130 participants met the inclusion criteria. Propranolol was found to be a more effective modality in treating IHs (ORs = 0.92; 95%CI, 0.89–0.95) and had fewer complications compared to the other treatments including systemic steroids (ORs = 0.68; 95% CI, 0.59–0.76); laser ablation (ORs = 0.55; 95% CI, 0.43–0.67); other beta-adrenergic blockers (ORs = 0.56; 95% CI, 0.50–0.61) and surgery (ORs = 0.55; 95% CI, 0.28–0.81). A subgroup analysis of propranolol showed that a dose of 2 mg/kg/day or more yielded better outcomes (ORs = 0.92; 95% CI, 0.88–0.95; ORs = 0.95; 95% CI, 0.89–1.00), and IHs that had not been previously treated had better responses to propranolol treatment (ORs = 0.95; 95% CI, 0.91–0.98).ConclusionsThe meta-analysis demonstrated that propranolol was more effective and safer than other therapies in treating IHs. It provides strong evidence for supporting the use of propranolol as a first-line therapy for IHs.

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Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Oral Propranolol versus Other Treatments for Infantile Hemangiomas: A Meta-Analysis

Liu

Zheng

et al. 2015

PLoS ONE

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“…Most lesions can be managed in this way with an average of three excisions. 48 For deep lesions that do not involve the cutaneous surface, a plane of dissection can be created between the mass and the overlying normal skin. This allows for removal of all or a portion of the lesion without disrupting the uninvolved skin.…”

Section: Congenital Hemangiomasmentioning

confidence: 99%