Serial Evaluation of Academic and Behavioral Outcome After Treatment With Cranial Radiation in Childhood

Mabbott, Donald; Spiegler, Brenda J.; Greenberg, Mark; Rutka, James T.; Hyder, Douglas J.; Bouffet, Éric

doi:10.1200/jco.2005.01.158

Cited by 231 publications

(178 citation statements)

References 25 publications

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“…In contrast, others have observed nearly 1 standard deviation below the normative mean in children medulloblastoma (Brinkman et al 2012), though the authors report no correlation between IQ and estimates of FA, ADC, or radial diffusivity. In a similar study, Mabbott et al (2005) reported a significant correlation between mean FSIQ measures and FA values. However, this finding was not significant until an outlier was removed from the dataset.…”

Section: Diffusion Tensor Imaging and Functionmentioning

confidence: 75%

“…Diffuse and nonfocal increases in ADC have also been implicated in those treated with high doses of cranial radiation (Law et al 2011;Mabbott et al 2005). It is clear from these studies that white matter integrity is compromised in a wide range of frontal and posterior white matter projections.…”

Section: Diffusion Tensor Imaging and White Matter Integritymentioning

confidence: 77%

“…Radiation may have a dose-dependent impact on some neurocognitive domains (Merchant et al 2006), though it is still unclear what specific domains are sensitive to radiation as individuals may differ considerably in their neurocognitive functioning both before and after radiation treatment. There is some evidence that those treated with lower doses of radiation may demonstrate areas of better neurocognitive functioning than those treated with higher doses (Mabbott et al 2005;Mulhern et al 2005). However, less is known about how differing levels of radiation affect brain structure and function given that most of the studies evaluating brain and behavior relationships include only participants with total doses above 50 Gy.…”

Section: Radiation Dosementioning

confidence: 99%

“…In general, studies have observed decreased FA values in several white matter networks including frontal and parietal periventricular white matter, corpus callosum, corona radiata, right inferior fronto-occipital fasciculus, anterior and posterior limbs of the internal capsule, inferior frontal white matter, high frontal white matter, pons, medulla oblongata, and cerebello-thalamo-cerebral tracts (Aukema et al 2009;Khong et al 2003;Khong et al 2005;Law et al 2011;Leung et al 2004;Mabbott et al 2005). …”

Section: Diffusion Tensor Imaging and White Matter Integritymentioning

confidence: 99%

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Effects of Cranial Radiation on Structural and Functional Brain Development in Pediatric Brain Tumors

Bledsoe

2015

J Pediatr Neuropsychol

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There is emerging research connecting neuroimaging correlates and neurocognitive functioning in pediatric brain tumors. Current work has attempted to measure the impact of cranial radiation on brain and behavior outcomes with the goal of better understanding the mechanisms of treatment late effects. While critical for treatment, cranial radiation can have a substantial impact on the developing brain and on neuropsychological development. This paper provides a critical review of the most recent empirical structural and functional neuroimaging research evaluating the impact of cranial radiation on neuropsychological functioning in pediatric brain tumors. The importance in study methodology, potential outcome moderating variables, limitations, and future directions is discussed.

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Section: Diffusion Tensor Imaging and Functionmentioning

confidence: 75%

Section: Diffusion Tensor Imaging and White Matter Integritymentioning

confidence: 77%

Section: Radiation Dosementioning

confidence: 99%

Section: Diffusion Tensor Imaging and White Matter Integritymentioning

confidence: 99%

See 2 more Smart Citations

Effects of Cranial Radiation on Structural and Functional Brain Development in Pediatric Brain Tumors

Bledsoe

2015

J Pediatr Neuropsychol

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“…Measurement of neurocognitive function is not built into the study. It is known that several factors can contribute to impaired function, including overproduction of cerebrospinal fluid, chronic hydrocephalus, and surgery for the tumor and its complications [107][108][109][110]. In this context, cumulative neurotoxicity from the addition of adjuvant radiation must be carefully weighed, given the absence of strong evidence of benefit from this modality.…”

Section: Choroid Plexus Tumorsmentioning

confidence: 99%

Current Treatment Approaches for Infants with Malignant Central Nervous System Tumors

Lafay‐Cousin

Strother

2009

The Oncologist

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DisclosuresLucie Lafay-Cousin: None; Douglas Strother: None.Section editors Susan M. Blaney and Ross Pinkerton have disclosed no financial relationships relevant to the content of this article.The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. LEARNING OBJECTIVES1. Evaluate the challenges of identifying very young children with brain tumors so that they can be enrolled in clinical trials.2. Identify prognostic factors for children with certain brain tumors and assess the influence of these factors on current therapeutic strategies.3. Outline factors affecting survival and neurocognitive outcome of children with malignant brain tumors.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACT

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Guidelines for Identification of, Advocacy for, and Intervention in Neurocognitive Problems in Survivors of Childhood Cancer

Nathan

Patel

Dilley

et al. 2007

Arch Pediatr Adolesc Med

207

170

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With modern therapies and supportive care, survival of childhood cancer has increased considerably. Patients who have survived cancers involving the central nervous system or who have received therapy toxic to the developing brain are at risk of long-term neurocognitive sequelae. Negative outcomes are observed most frequently in survivors of acute lymphoblastic leukemia and brain tumors. The Children's Oncology Group Long-term Follow-up Guidelines Task Force on Neurocognitive/Behavioral Complications After Childhood Cancer has generated risk-based, exposure-related guidelines designed to direct the follow-up care of survivors of pediatric malignancies based on a comprehensive literature review and expert opinion. This article expands on these guidelines by reviewing the risk factors for the development of neurocognitive sequelae and describing the expected pattern of these disabilities. We herein present recommendations for the screening and management of neurocognitive late effects and outline important areas of school and legal advocacy for survivors with disabilities. Finally, we list resources that can guide patients, their parents, and their medical caregivers as they face the long-term neurocognitive consequences of cancer therapy.

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Serial Evaluation of Academic and Behavioral Outcome After Treatment With Cranial Radiation in Childhood

Abstract: Cranial radiation is associated with declines in academic ability, social skills, and attention. However, neither psychological distress nor behavior problems were a significant concern for this sample.

Cited by 231 publications

References 25 publications

Effects of Cranial Radiation on Structural and Functional Brain Development in Pediatric Brain Tumors

Effects of Cranial Radiation on Structural and Functional Brain Development in Pediatric Brain Tumors

Current Treatment Approaches for Infants with Malignant Central Nervous System Tumors

Guidelines for Identification of, Advocacy for, and Intervention in Neurocognitive Problems in Survivors of Childhood Cancer

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