Serial echocardiographic evaluation of left ventricular function in valvular disease, including reproducibility guidelines for serial studies.

Clark, Ralph; Korcuska, Kathleen; Cohn, Keith

doi:10.1161/01.cir.62.3.564

Cited by 56 publications

(11 citation statements)

References 34 publications

(5 reference statements)

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“…[17][18][19] LV filling was assessed from conventional evaluation of the early maximum (E) and atrial (A) LV filling inflow velocities and their ratio (E/A). 20…”

Section: Doppler Echocardiographymentioning

confidence: 99%

Hemodynamic effects of inducible nitric oxide synthase and nitrotyrosine generation in heart failure

Vanderheyden¹,

Bartúnek²,

Knaapen³

et al. 2004

The Journal of Heart and Lung Transplantation

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“…[17][18][19] LV filling was assessed from conventional evaluation of the early maximum (E) and atrial (A) LV filling inflow velocities and their ratio (E/A). 20…”

Section: Doppler Echocardiographymentioning

confidence: 99%

Hemodynamic effects of inducible nitric oxide synthase and nitrotyrosine generation in heart failure

Vanderheyden¹,

Bartúnek²,

Knaapen³

et al. 2004

The Journal of Heart and Lung Transplantation

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“…The use of serial echocardiographic measurements of left ventricular dimensions and function has been ham-pered by problems of measurement reproducibility [1][2][3] . Variability and bias in quantitative echocardiography are introduced both during image acquisition and by measuring cardiac dimensions and derived function.…”

Section: Introductionmentioning

confidence: 99%

“…Variability and bias in quantitative echocardiography are introduced both during image acquisition and by measuring cardiac dimensions and derived function. Despite little difference between means, the 95% confidence interval for a single replicate measurement is often wide [2][3][4][5][6] . Serial studies introduce temporal variation of the reader and regression to the mean as additional sources of variability and bias [1] .…”

Section: Introductionmentioning

confidence: 99%

Differences Between Echocardiographic Measurements of Left Ventricular Dimensions and Function by Local Investigators and a Core Laboratory in a 2-year Follow-up Study of Patients with an Acute Myocardial Infarction

Hole¹,

Otterstad

Sutton

et al. 2002

European Heart Journal - Cardiovascular Imaging

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Aims: To examine differences in measurements of left ventricular dimensions and function, and prognostic value between local investigators and a core laboratory in a multicentre serial echocardiographic study. Methods and Results:Seven hundred and fifty-six patients with acute myocardial infarction and preserved left ventricular function were examined at baseline and after 3 months with measurements by the biplane Simpson's method, and followed prospectively from 3 to 24 months. At baseline and 3 months local investigators relative to the core laboratory measured lesser end-diastolic volume by 8 and 6 ml (P<0·001), end-systolic volume by 3 and 2 ml (P<0·01), and ejection fraction by 0·0 and 0·6% (P<0·01), respectively. Local investigators and the core laboratory measured an increase in left ventricular end-diastolic volume of 8·6 and 6·9 ml, and in left ventricular end-systolic volume of 5·2 and 4·3 ml, and a decrease in left ventricular ejection fraction of 0·6 and 0·0%. Using the Cox proportionate hazards model, the prognostic value for subsequent clinical endpoints was significant both for the 3-month values (P<0·05) and changes (P<0·005) measured by the core laboratory, but not by local investigators. Conclusion:Only measurements in the core laboratory had significant prognostic value for subsequent clinical endpoints. These results strongly support the use of a core laboratory in studies employing echocardiographic measurements.

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“…Echophonocardiographic measurements were, therefore, repeated at intervals over several months. Although reproducibility studies were not performed, others "' 14 19 have shown a small standard deviation for systolic time intervals (for example 5 ms 217 for left ventricular ejection time; 4 ms for pre-ejection period) and for velocity of circumferential fibre shortening (0.05 circumferences per s) when repeated at intervals over weeks in the same subjects. A preliminary study of four normal subjects on four separate occasions using the above protocol showed similar day to day variability in these indices.…”

mentioning

confidence: 97%

Delayed recovery of left ventricular function after antithyroid treatment. Further evidence for reversible abnormalities of contractility in hyperthyroidism.

Forfar¹,

Matthews²,

Toft³

1984

Heart

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SUMMARY Sequential measurements of systolic time intervals, left ventricular dimensions, and the derived indices of contractility were undertaken at rest and during isometric exercise in 15 hyperthyroid patients before, during, and after antithyroid treatment. At rest hyperthyroidism was characterised by a shortened pre-ejection period and increased velocity of circumferential shortening of the left ventricle. During isometric exercise, however, the pre-ejection period increased significantly beyond that predicted for normal subjects, and the velocity of circumferential fibre shortening fell by 30%. In contrast, both the pre-ejection period and the velocity of circumferential fibre shortening were unchanged during exercise after a stable euthyroid state had been achieved for at least three months. Comparison between exercise responses and thyroid status during antithyroid treatment showed that a biochemical euthyroid state may be achieved many weeks before normalisation of contractile response to exercise.These findings support the hypothesis of reversible depression of left ventricular function in hyperthyroidism. Responses at rest principally reflect the-peripheral actions of thyroid hormone excess.Assessment of intrinsic contractile function of the heart in hyperthyroidism in man is complicated by an increase in preload from increased circulating blood volume' and a substantial fall in afterload from reduced peripheral vascular resistance.2 A recent study noted a 34% increase in left ventricular end diastolic volume and a 46% fall in peripheral vascular resistance in hyperthyroid subjects compared with euthyroid subjects atrially paced to the same heart rate. Isometric exercise is a convenient means of stressing the myocardium and increases oxygen consumption through a combination of increased afterload, inotropic activity, and heart rate. During such exercise repeated non-invasive measurements of myocardial dimensions and contractile function may be made by echophonocardiography. Since we have recently found abnormal left ventricular function during dynamic exercise in hyperthyroidism,9 the purpose of this study was to examine simultaneously isovolumetric and ejection phase indices of myocardial contractility during isometric exercise in hyperthyroid patients before and at intervals during or after antithyroid treatment. In addition, the effect of autonomic blockade was examined to determine the influence of vagal and sympathetic activity on the responses observed. The study was designed both to confirm or refute the abnormalities on dynamic exercise and to determine prospectively whether a direct

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Serial echocardiographic evaluation of left ventricular function in valvular disease, including reproducibility guidelines for serial studies.

Cited by 56 publications

References 34 publications

Hemodynamic effects of inducible nitric oxide synthase and nitrotyrosine generation in heart failure

Hemodynamic effects of inducible nitric oxide synthase and nitrotyrosine generation in heart failure

Differences Between Echocardiographic Measurements of Left Ventricular Dimensions and Function by Local Investigators and a Core Laboratory in a 2-year Follow-up Study of Patients with an Acute Myocardial Infarction

Delayed recovery of left ventricular function after antithyroid treatment. Further evidence for reversible abnormalities of contractility in hyperthyroidism.

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