Serial Dependence across Perception, Attention, and Memory

Kiyonaga, Anastasia; Scimeca, Jason M.; Bliss, Daniel P.; Whitney, David

doi:10.1016/j.tics.2017.04.011

Cited by 244 publications

(330 citation statements)

References 17 publications

Supporting

Mentioning

282

Contrasting

Order By: Relevance

“…Rather, it states the necessity of assuming alterations in a mechanism operating on longer timescales, such as STP. Our findings advance the conceptual understanding of working memory alterations in schizophrenia and anti-NMDAR encephalitis, as they demonstrate a selective disruption of information carryover between trials, reflected by a reduction of serial biases robustly found in neurotypical subjects 13 . While we could not find correlations of reduced serial dependence with psychiatric scales ( Supplementary Fig.…”

Section: Methodssupporting

confidence: 61%

“…This suggests that serial biases reflect a clinically relevant dimension not captured in psychiatric scales. In this sense, it has been argued that serial dependence could facilitate information processing in temporally coherent real-world situations 13 . Alternatively, serial biases could be the mere by-product of long-lasting cellular or synaptic mechanisms that support memory stabilization during working memory delays 30 .…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Stein

Barbosa

Rosa-Justicia

et al. 2019

Preprint

View full text Add to dashboard Cite

We report markedly reduced working memory-related serial dependence with preserved memory accuracy in anti-NMDAR encephalitis and schizophrenia. We argue that NMDAR-related changes in cortical excitation, while quickly destabilizing persistent neural activity, cannot fully account for a reduction of memory-dependent biases. Rather, our modeling results support a disruption of a memory mechanism operating on a longer timescale, such as short-term potentiation.The NMDA receptor (NMDAR) subserves memory mechanisms at several timescales, including sustained working memory delay activity 1,2 and different temporal components of synaptic potentiation 3,4 . In addition, hypofunction of NMDARs is linked to psychiatric disease, in particular schizophrenia 5 , and it possibly contributes to abnormal working memory function in patients with schizophrenia 6,7 . Indeed, reduced prefrontal NMDAR density characterizes this disease 8 . Yet, the specific neural alterations by which NMDAR hypofunction could lead to memory deficits in schizophrenia are still under debate 6,7 . Here, we studied working memory function in healthy controls, patients with schizophrenia, and patients recovering from anti-NMDAR encephalitis ( Methods , Supplementary Table 1). Anti-NMDAR encephalitis is characterized by an antibody-mediated reduction of NMDARs, accompanied by initial psychosis and long-lasting memory deficits 9,10 , resembling clinical features of schizophrenia 11 .Consequently, we expected working memory deficits in anti-NMDAR encephalitis to parallel those in schizophrenia. This correspondence allows linking alterations in working memory to the NMDAR in both patient groups.We assessed memory alterations in a visuospatial delayed-response task (Fig. 1a) on two coexisting temporal scales: single-trial working memory accuracy as a proxy of active memory maintenance during short delays, and serial dependence of responses on previously memorized stimuli 12,13 (serial biases, Fig. 1b) as a read-out of passive information maintenance across trials. Neural correlates of this task have been identified in monkey prefrontal cortex 14,15 , inspiring computational models that can capture key aspects of neural dynamics and behavior [15][16][17][18][19] . The biophysical detail of these models permits to investigate how NMDAR hypofunction at different synaptic sites affects circuit dynamics and working memory.Candidate mechanisms are a disturbed balance between cortical excitation and inhibition (E/I balance), as it is observed in schizophrenia and in studies using NMDAR antagonists (e.g. ketamine) 2,5,20,21 , and alterations in NMDAR-regulated short-term synaptic potentiation 3,4,22 . In the modeling section of this study (Figs. 2,3), we systematically tested the potential of these candidate mechanisms for explaining experimentally observed memory alterations in schizophrenia and anti-NMDAR encephalitis.First, we sought to identify alterations in single-trial working memory accuracy, as an indication of a possible dysfunction of activity-based memory...

show abstract

Section: Methodssupporting

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Stein

Barbosa

Rosa-Justicia

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Priming generally manifests in reaction time (Kahneman, Treisman, & Gibbs, 1992;Maljkovic & Nakayama, 1994, 1996 and, where relevant, can improve discriminability of primed stimuli (Sigurdardottir, Kristjansson, & Driver, 2008); serial dependence does not impact reaction time and is a reduction in the discriminability of similar objects Liberman et al, 2014), for the sake of perceptual stability. The CF is a spatiotemporal operator that may influence perception, memory, decision, and action (Kiyonaga, Scimeca, Bliss, & Whitney, 2017). It can affect appearance: it makes (even slightly different) objects look the same over time (Cicchini et al, 2017;.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, if the serial dependence mechanism were only based on sequential decisions, serial dependence should occur independent of face identity, and should not be gender-specific (as shown in Experiment 2). Memory was also proposed as a component of serial dependence, manifesting in terms of proactive interference Kiyonaga et al, 2017). Interestingly, proactive interference may simply be a special kind of serial dependence which occurs in memory.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is a great deal of debate surrounding the origin of sequential dependencies in perception Cicchini et al, 2017;Fritsche et al, 2017;Kiyonaga et al, 2017;Liberman et al, 2014;Pascucci et al, 2017;Suárez-Pinilla, Anil, & Roseboom, 2018), serial dependence may very likely happen at every level of visual and cognitive processing (perception, attention, decision, memory, and motor systems), and future research should investigate the interaction (and degree of independence) between all these components. Whereas our data cannot clearly disentangle between these different components, they provide further insights regarding the types of information and selectivity that serial dependence can exhibit.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serial dependence promotes the stability of perceived emotional expression depending on face similarity

Liberman

Manassi

Whitney

2018

Atten Percept Psychophys

Self Cite

View full text Add to dashboard Cite

Individuals can quickly and effortlessly recognize facial expressions, which is critical for social perception and emotion regulation. This sensitivity to even slight facial changes could result in unstable percepts of an individual's expression over time. The visual system must therefore balance accuracy with maintaining perceptual stability. However, previous research has focused on our sensitivity to changing expressions, and the mechanism behind expression stability remains an open question. Recent results demonstrate that perception of facial identity is systematically biased toward recently seen visual input. This positive perceptual pull, or serial dependence, may help stabilize perceived expression. To test this, observers judged random facial expression morphs ranging from happy to sad to angry. We found a pull in perceived expression toward previously seen expressions, but only when the 1-back and current face had similar identities. Our results are consistent with the existence of the continuity field for expression, a specialized mechanism that promotes the stability of emotion perception, which could help facilitate social interactions and emotion regulation.

show abstract

Short-Term Synaptic Plasticity: Microscopic Modelling and (Some) Computational Implications

Barri

Mongillo

2021

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Serial Dependence across Perception, Attention, and Memory

Cited by 244 publications

References 17 publications

Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Serial dependence promotes the stability of perceived emotional expression depending on face similarity

Short-Term Synaptic Plasticity: Microscopic Modelling and (Some) Computational Implications

Contact Info

Product

Resources

About