Serial cholinesterase estimation in carbamate poisoning

Pinakini, KS; Kumar, TK Susheel

doi:10.1016/j.jcfm.2005.11.005

Cited by 17 publications

(2 citation statements)

References 7 publications

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“…Hydrolysis mechanism of carbofuran (Filik and Çekiç, 2011) Hydrolysis Cycoń et al, 2017). The measured half-lives of carbofuran under acidic and alkaline conditions were 320 days and 150 days, respectively (Pinakini & Kumar, 2006). Seiber and colleagues demonstrated that at pH 10, carbofuran hydrolysed 700 times faster than at pH 7, with half-lives of 1.2 and 864 hours, respectively.…”

Section: Hydrolysis Degradationmentioning

confidence: 99%

Understanding the Degradation of Carbofuran in Agricultural Area: A Review of Fate, Metabolites, and Toxicity

Baharudin,

Ahmad,

Hossain

2023

JST

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Pesticides are commonly applied in agriculture to manage pests, parasites, weeds, and other crop diseases to maximise product output value and minimise or reduce yield losses. Pesticides are widely and indiscriminately used in crop production in most countries. Carbofuran is a highly toxic insecticide commonly used to protect crops in agricultural areas. Exposure to carbofuran can cause harmful effects on both the ecological environment and human health, particularly on non-target species such as birds and aquatic organisms. Carbofuran continues to be used, although it has been banned in some countries. This review paper highlights carbofuran usage, its residue, toxicity, and mechanisms of degradation pathways in water, soil, and food, especially in agriculture. It has been shown that hydrolysis, photolysis, and microbial degradation are the main pathways for carbofuran degradation. Carbofuran phenol is significantly less toxic than all photo-metabolites, while 3-ketocarbofuran and 3-hydroxycarbofuran are practically as harmful as the parent compound. Hence, more study is needed on degradation pathways that may thoroughly minimise the toxicity of this deadly pesticide.

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Section: Hydrolysis Degradationmentioning

confidence: 99%

Understanding the Degradation of Carbofuran in Agricultural Area: A Review of Fate, Metabolites, and Toxicity

Baharudin,

Ahmad,

Hossain

2023

JST

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“…Ce tableau très évocateur est lié à l'inondation cholinergique de l'organisme due à l'inhibition des cholinestérases [3][4][5].…”

Section: Chromatographie En Phase Gazeuse Couplée à La Spectrométrie unclassified

Problématique de l’intoxication par un rodenticide non autorisé à la commercialisation en Algérie : identification de sa matière active

Aoul

Zamoum²,

Aissani³

et al. 2011

Ann Toxicol Anal

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Résumé -Objectif : 1136 cas d'intoxications volontaires ou accidentelles ont été enregistrés au Centre Antipoison du CHU Bab El Oued d'Alger durant la décennie (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008), par un produit rodenticide commercialisé sous le nom de « Rat Killer » et sans mention de sa composition. La symptomatologie décrite comporte essentiellement des signes cholinergiques. Afin d'élucider cette ambiguïté, l'identification du produit s'imposait. Méthodes : Trois techniques chromatographiques ont été utilisées : chromatographie sur couche mince, chromatographie en phase gazeuse couplée à la spectrométrie de masse et chromatographie liquide couplée à la spectrométrie de masse. Résultats : L'analyse du produit confirmée par des méthodes différentes et complémentaires, met en évidence la présence de Carbofuran, insecticide de la famille des carbamates inhibiteurs de l'activité cholinéstérasique. Conclusion : l'identification du produit a permis de dénoncer une fraude et d'interpeller les pouvoirs publics quant à la commercialisation illégale et informelle de ces pesticides détournés de leur usage initial, et qui plus est interdits à l'importation en Algérie. Par ailleurs, cela a conforté le clinicien dans la prise en charge de cette intoxication.Mots clés : Intoxication, signes cholinergiques, matière active, méthodes chromatographiques, identification Abstract -Objectives: 1136 cases of voluntary or accidental intoxications have been registered at the anti-poison centre of Bab El Oued Academic Hospital during this last decade. These intoxications were due to a rodenticide product marketed under the name "Rat Killer" without any information about its components. The reported symptoms were essentially cholinergic signs. The aim of the study was to identify the "Rat Killer"'s components. Method: Three chromatographic techniques were used: thin-layer chromatography, liquid chromatography coupled with mass spectrometry and gas chromatography coupled with mass spectrometry. Results: The product analysis by the three different complementary methods highlighted the presence of Carbofuran, an insecticide belonging to the carbamate family, an inhibitor of cholinesterase activity. Conclusion: The product identification allowed a fraud denunciation and drew the public authorities' attention to the illegal and unofficial marketing of these pesticides that were diverted from their initial use and that are prohibited for import in Algeria. Moreover, this identification process enabled the clinician to manage this poisoning.

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Role of the Laboratory in Detecting Other Poisoning, Including Pesticides, Ethylene Glycol, and Methanol

Dasgupta

2012

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring

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Serial cholinesterase estimation in carbamate poisoning

Cited by 17 publications

References 7 publications

Understanding the Degradation of Carbofuran in Agricultural Area: A Review of Fate, Metabolites, and Toxicity

Understanding the Degradation of Carbofuran in Agricultural Area: A Review of Fate, Metabolites, and Toxicity

Problématique de l’intoxication par un rodenticide non autorisé à la commercialisation en Algérie : identification de sa matière active

Role of the Laboratory in Detecting Other Poisoning, Including Pesticides, Ethylene Glycol, and Methanol

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