Serial changes in systolic and diastolic echocardiographic indices as predictors of outcome in patients with decreased left ventricular ejection fraction

Bierig, S. Michelle; Ryan, Amanda; Ziaee, Ali; Kociolek, Larry K.; Simon, Jacqueline; Herrmann, Steven C.; Labovitz, Arthur J.

doi:10.1016/j.euje.2006.07.007

Cited by 1 publication

(1 citation statement)

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“…In another study, the mitral E/e’ ratio ( P < 0.001) and the Tei index (index of myocardial performance incorporating both systolic and diastolic time) but not the ejection fraction, were the only independent predictors of death or heart failure admission ( P = 0.019) 50. Within a cohort with severely decreased ejection fraction ≤30%, diastolic indexes of mitral inflow significantly predicted poor outcomes, while ejection fraction did not 51. A restrictive filling pattern was the only independent predictor of death or appropriate defibrillator shock 52.…”

Section: Diastolic Dysfunction Predicts Poor Prognosis Regardless Of mentioning

confidence: 96%

Diuretics as pathogenetic treatment for heart failure

Guglin

2011

IJGM

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Increased intracardiac filling pressure or congestion causes symptoms and leads to hospital admissions in patients with heart failure, regardless of their systolic function. A history of hospital admission, in turn, predicts further hospitalizations and morbidity, and a higher number of hospitalizations determine higher mortality. Congestion is therefore the driving force of the natural history of heart failure. Congestion is the syndrome shared by heart failure with preserved and reduced systolic function. These two conditions have almost identical morbidity, mortality, and survival because the outcomes are driven by congestion. A small difference in favor of heart failure with preserved systolic function comes from decreased ejection fraction and left ventricular remodeling which is only present in heart failure with decreased systolic function. The magnitude of this difference reflects the contribution of decreased systolic function and ventricular remodeling to the progression of heart failure. The only treatment available for congestion is fluid removal via diuretics, ultrafiltration, or dialysis. It is the only treatment that works equally well for heart failure with reduced and preserved systolic function because it affects congestion, the main pathogenetic feature of the disease. Diuretics are pathogenetic therapy for heart failure.

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Section: Diastolic Dysfunction Predicts Poor Prognosis Regardless Of mentioning

confidence: 96%

Diuretics as pathogenetic treatment for heart failure

Guglin

2011

IJGM

View full text Add to dashboard Cite

show abstract

Serial changes in systolic and diastolic echocardiographic indices as predictors of outcome in patients with decreased left ventricular ejection fraction

Cited by 1 publication

References 39 publications

Diuretics as pathogenetic treatment for heart failure

Diuretics as pathogenetic treatment for heart failure

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