Serial Changes in 24 Hour Creatinine Clearance During Normal Menstrual Cycles and the First Trimester of Pregnancy

Davison, John M.; Noble, Matt

doi:10.1111/j.1471-0528.1981.tb00930.x

Cited by 196 publications

(122 citation statements)

References 30 publications

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“…Our results support the hypothesis that hormonal changes seen during the menstrual cycle affect renal elimination, Previous reports have demonstrated a 5-20% increase in GFR during luteal phase, which is consistent with our results (Br~chner et al 1987;Davison and Noble, 1981;Paaby et al, 1987;Bisdee et al, 1989).…”

Section: Resultssupporting

confidence: 83%

Annual Review of Chronopharmacology. Volume 7. Biological Rhythms and Medications. Proceedings of the Conference of Chronopharmacology Held in Nice, France on 12-15 March 1990

Reinberg¹,

Smolensky²,

Labrecque³

1990

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Section: Resultssupporting

confidence: 83%

Annual Review of Chronopharmacology. Volume 7. Biological Rhythms and Medications. Proceedings of the Conference of Chronopharmacology Held in Nice, France on 12-15 March 1990

Reinberg¹,

Smolensky²,

Labrecque³

1990

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“…The stimulus for secretion of RLX by the corpus luteum is human chorionic gonadotrophin (hCG), which rises in parallel (1). Second, circulating RLX also increases during the luteal phase of the menstrual cycle (1,(4)(5)(6), coinciding with a transient 20% increase in GFR and ERPF (7)(8)(9)(10)(11)(12). Third, the gestational rise in RLX corresponds with another early physiological adaptation in human pregnancy, namely, osmoregulatory changes (13).…”

Section: Introductionmentioning

confidence: 99%

Relaxin is a potent renal vasodilator in conscious rats

Danielson¹,

Sherwood²,

Conrad³

1999

J. Clin. Invest.

238

254

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The hormone relaxin (RLX) has a molecular weight of approximately 5,000-6,000 and is a member of the insulin-growth factor family. In humans and rats, the ovary is the major, if not sole, source of circulating RLX. In pregnant rats, RLX promotes growth and softening of the cervix and vagina, promotes growth of the mammary nipples, and inhibits spontaneous uterine contractility (reviewed in ref. 1).During early pregnancy in humans, rats, and other mammals, vasodilation of nonreproductive organs leads to a marked decline in total peripheral vascular resistance (2). The kidneys contribute to this fall in peripheral resistance; a nadir in renal vascular resistance and a reciprocal peak in renal blood flow and glomerular filtration rate of 40%-80% above nonpregnant levels are reached by the end of the first trimester in women (reviewed in ref.3). Maximal changes, albeit of a lesser magnitude (20%-40% from nonpregnant levels), are observed in the renal circulation of conscious rats by gestational day 12 (3).The "pregnancy hormones" that cause renal vasodilation and hyperfiltration have not been identified. For several reasons, we hypothesized that RLX contributes. First, the plasma concentration of RLX increases rapidly after conception in women (reviewed in ref. 1), corresponding with the marked increase in both glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) during the first trimester (3). The stimulus for secretion of RLX by the corpus luteum is human chorionic gonadotrophin (hCG), which rises in parallel (1). Second, circulating RLX also increases during the luteal phase of the menstrual cycle (1, 4-6), coinciding with a transient 20% increase in GFR and ERPF (7-12). Third, the gestational rise in RLX corresponds with another early physiological adaptation in human pregnancy, namely, osmoregulatory changes (13). Chronic administration of recombinant human RLX 2 (rhRLX) to ovariectomized rats reduced plasma osmolality and the osmotic threshold for arginine vasopressin release to levels comparable to the gravid condition (14). Fourth, the osmoregulatory changes of pregnancy were mimicked by administering hCG to women in the luteal phase of the menstrual cycle and intact female rats, but not to men or ovariectomized rats, suggesting the intermediary role of an ovarian hormone (15-17). Associated with the osmoregulatory changes observed in women after administration of hCG was a 15%-20% rise in GFR, which again was not observed in men administered the hormone (Davison, J.M., personal communication). Fifth, although renal vasodilation and hyperfiltration are observed in gravid rats as early as day 5 of gestation, before detectable increases in ovarian and plasma RLX occur, there is a marked jump in GFR and ERPF between gestational days 8 and 12 (18) Received for publication October 27, 1998, and accepted in revised form January 4, 1999. Relaxin is a potent renal vasodilator in conscious ratsThe kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy h...

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“…These changes include increases in glomerular filtration rate (G.F.R. ), glucose excretion and tubular reabsorption of salt and water and are associated with an increased extracellular volume (Hytten & Leitch, 1971;Davidson & Hytten, 1974, 1975Davison & Noble, 1981;Dunlop, 1981). Appropriate investigations of single nephrons or parts of nephrons to elucidate the mechanisms underlying these gross changes cannot be performed in humans, however.…”

Section: Introductionmentioning

confidence: 99%

Micropuncture study of changes in glomerular filtration and ion and water handling by the rat kidney during pregnancy

Garland

Green

1982

The Journal of Physiology

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SUMMARY1. In rats receiving 200 gl. min-sodium chloride, glomerular filtration rate, single nephron glomerular filtration rate, and fractional reabsorption were measured at various points along the nephron, and ionic concentrations measured in early distal tubular fluid in virgin and 6, 12 and 19 day pregnant rats.2. Glomerular filtration increased progressively until the twelfth day ofpregnancy. At 19 days of pregnancy the glomerular filtration rate, while still above virgin levels, was reduced below 12 day pregnant levels.3. Single nephron glomerular filtration rates measured in proximal and distal tubules were different at both 12 and 19 days of pregnancy, indicating an alteration of tubuloglomerular feed-back. 4. A change in the ratio ofglomerular filtration rate: distal single nephron filtration rate indicated a redistribution of glomerular filtrate to juxtamedullary nephrons by the sixth day of pregnancy.5. Fluid reabsorption is similar up to the early distal tubule but it is not possible to say whether reabsorption is the same in proximal tubules. More fluid is reabsorbed by late distal tubules and collecting ducts in 12 and 19 day pregnant animals than in the virgin and 6 day pregnant animals.6. Changes in ion reabsorption by the loop of Henle occurred during pregnancy; sodium reabsorption was increased by the sixth day of pregnancy and potassium reabsorption by the twelfth day.

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Serial Changes in 24 Hour Creatinine Clearance During Normal Menstrual Cycles and the First Trimester of Pregnancy

Cited by 196 publications

References 30 publications

Annual Review of Chronopharmacology. Volume 7. Biological Rhythms and Medications. Proceedings of the Conference of Chronopharmacology Held in Nice, France on 12-15 March 1990

Annual Review of Chronopharmacology. Volume 7. Biological Rhythms and Medications. Proceedings of the Conference of Chronopharmacology Held in Nice, France on 12-15 March 1990

Relaxin is a potent renal vasodilator in conscious rats

Micropuncture study of changes in glomerular filtration and ion and water handling by the rat kidney during pregnancy

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