Serial biochemical and endocrine investigations in recurrent mental illness

Rey, Joan; Willcox, D. R. C.; Gibbons, J. L.; Tait, H. Sinclair; Lewis, Deanna

doi:10.1016/0022-3999(61)90042-3

Cited by 13 publications

(1 citation statement)

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“…Alterations in electrolyte metabolism and cation transport have also been implicated as having a role in the genesis of affective illness, with abnormalities in sodium, magnesium, calcium concentration and lithium tissue distribution having been reported. Some studies (Rey et al 1961;Klein & Nunn, 1945;Gibbons, 1960;Anderson & Dawson, 1963), but not all (Russell, 1960), have reported a reversible retention of water and Na in depressed patients. An initial study, using an isotope dilution technique, indicated that, while there was no overall change in Na balance, residual Na (composed of intracellular Na and exchangeable bone Na) was increased in both depressed (Coppen & Shaw, 1963) and manic (Coppen et al 1966) patients, and returned to normal levels with remission.…”

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confidence: 99%

Biological component of the NIMH Clinical Research Branch Collaborative Program on the psychobiology of depression: I. Background and theoretical considerations

Maas¹,

Koslow

Davis³

et al. 1980

Psychol. Med.

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SYNOPSISThere are many reports which suggest that patients with affective illness (mania and/or depression) have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, these findings were reviewed and some of the factors impeding movement towards a more complete and integrated view of the functioning of neurobiological systems in patients with mania or depression were identified. As a result, a multi-research centre, collaborative approach to the study of the psychobiology of affective disorders was developed. In this collaborative programme, which has now been underway for several years, the focus has been upon: (a) the assessment of the functioning of several different types of biological systems in the same patient, both before and during treatment; (b) obtaining a reasonably large number of patients and comparison subjects; and (c) the use within and across centres of standardized diagnostic categories and behavioural rating methodologies. In this paper the history, background, and rationale for this collaborative effort are reviewed. Those biological systems chosen for study are noted, and issues such as reliability and validity of diagnoses, measurement of state variables, assessment of change with treatment, and logistical and coordinating problems are discussed.

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confidence: 99%