Serial assessment of thrombogenicity and hemodynamics in patients with type II diabetes in a clinical research unit: Evidence for circadian variations in clot formation

Chaudhary, Rahul; Sharma, Tushar; Tantry, Udaya S.; Asgar, Juzer Ali; Kundan, Parshotam; Duhan, Sanchit; Gill, Haroon; Singh, Arvind; Alasadi, Yazan; Gurbel, Paul A.; Bliden, Kevin P.

doi:10.1007/s11239-022-02699-1

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Circadian fluctuations in thrombogenicity and hemostasis play a role in acute cardiovascular thrombotic events that occur most frequently in the early morning (149,150). Early clinical studies revealed strikingly large-amplitude circadian changes in anticoagulation levels in patients with thrombosis receiving constant-rate unfractionated heparin, with values supporting a higher risk of rethrombosis in the morning and a higher risk of bleeding at night (151).…”

Section: Chronopharmacology Of Anticoagulantsmentioning

confidence: 99%

Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy

Lévi,

Okyar,

Hadadi

et al. 2024

Annu. Rev. Pharmacol. Toxicol.

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Today's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy, toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Experimental and human studies have recently revealed sexually dimorphic circadian drug responses. Dedicated randomized clinical trials should now aim to issue personalized circadian timing recommendations for daily medical practice, integrating innovative technologies for remote longitudinal monitoring of circadian metrics, statistical prediction of molecular clock function from single-timepoint biopsies, and multiscale biorhythmic mathematical modelling. Importantly, chronofit patients with a robust circadian function, who would benefit most from personalized chronotherapy, need to be identified. Conversely, nonchronofit patients could benefit from the emerging pharmacological class of chronobiotics targeting the circadian clock. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 64 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: Chronopharmacology Of Anticoagulantsmentioning

confidence: 99%

Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy

Lévi,

Okyar,

Hadadi

et al. 2024

Annu. Rev. Pharmacol. Toxicol.

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“…[25][26][27][28] Furthermore, stroke has been suggested to alter a patient's chronotype. 28 Fundamental risk factors in stroke such as blood pressure and metabolism, as well as mechanisms of relevance to stroke occurrence and injury propagation, including platelet aggregation, 29,30 thrombus formation, 31 and endothelial function 32 are all known to be influenced by circadian clocks. Recently, it has been suggested that the translational failure of neuroprotection and mechanism-driven therapies in stroke is in large part due to a disregard of opposing circadiandependent behaviors between diurnal humans and nocturnal rodents.…”

mentioning

confidence: 99%

Stroke in the Time of Circadian Medicine

Mergenthaler,

Balami,

Neuhaus

et al. 2024

Circulation Research

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Time-of-day significantly influences the severity and incidence of stroke. Evidence has emerged not only for circadian governance over stroke risk factors, but also for important determinants of clinical outcome. In this review, we provide a comprehensive overview of the interplay between chronobiology and cerebrovascular disease. We discuss circadian regulation of pathophysiological mechanisms underlying stroke onset or tolerance as well as in vascular dementia. This includes cell death mechanisms, metabolism, mitochondrial function, and inflammation/immunity. Furthermore, we present clinical evidence supporting the link between disrupted circadian rhythms and increased susceptibility to stroke and dementia. We propose that circadian regulation of biochemical and physiological pathways in the brain increase susceptibility to damage after stroke in sleep and attenuate treatment effectiveness during the active phase. This review underscores the importance of considering circadian biology for understanding the pathology and treatment choice for stroke and vascular dementia and speculates that considering a patient’s chronotype may be an important factor in developing precision treatment following stroke.

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Serial assessment of thrombogenicity and hemodynamics in patients with type II diabetes in a clinical research unit: Evidence for circadian variations in clot formation

Cited by 2 publications

References 37 publications

Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy

Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy

Stroke in the Time of Circadian Medicine

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