Serial analysis of stable nitrogen and carbon isotopes in hair: monitoring starvation and recovery phases of patients suffering from anorexia nervosa

Mekota, Anna-Maria; Grupe, Gisela; Ufer, Stefan; Cuntz, Ulrich

doi:10.1002/rcm.2477

Cited by 283 publications

(354 citation statements)

References 39 publications

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“…We asked how well the model could be inverted to predict the isotope ratio of the tap water for the city in which the hair sample originated. For these 65 hair samples, we again achieved 85% and 86% agreement, respectively, between the predicted and observed ''isotopic origins'' of both the ␦ 2 H h and ␦ 18 Hair has been shown to be a sequential recorder of changes in diet (3,12,(32)(33)(34)(35). Similarly, geographic movements by an individual between locations with contrasting tap-water isotope ratios should be detectable.…”

supporting

confidence: 56%

Hydrogen and oxygen isotope ratios in human hair are related to geography

Ehleringer

Bowen

Chesson

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

329

440

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We develop and test a model to predict the geographic region-oforigin of humans based on the stable isotope composition of their scalp hair. This model incorporates exchangeable and nonexchangeable hydrogen and oxygen atoms in amino acids to predict the ␦ 2 H and ␦ 18 O values of scalp hair (primarily keratin). We evaluated model predictions with stable isotope analyses of human hair from 65 cities across the United States. The model, which predicts hair isotopic composition as a function of drinking water, bulk diet, and dietary protein isotope ratios, explains >85% of the observed variation and reproduces the observed slopes relating the isotopic composition of hair samples to that of local drinking water. Based on the geographical distributions of the isotope ratios of tap waters and the assumption of a ''continental supermarket'' dietary input, we constructed maps of the expected average H and O isotope ratios in human hair across the contiguous 48 states. Applications of this model and these observations are extensive and include detection of dietary information, reconstruction of historic movements of individuals, and provision of regionof-origin information for unidentified human remains. stable isotopes ͉ water ͉ anthropology ͉ forensics ͉ meteoric water T he carbon (␦ 13 C), nitrogen (␦ 15 N), and sulfur (␦ 34 S) isotope ratios of humans, other animals, and microbes are strongly correlated with the isotope ratios of their dietary inputs (1-5). The adage ''You are what you eat'' reflects the observation that there are limited differences (Յ1‰) between heterotrophic organisms and their diet in either the ␦ 13 C or ␦ 34 S values (6-8). These small isotopic differences arise because of fractionation events during metabolism; they also reflect that diet-derived carbon and sulfur are the only input sources into most heterotrophs. Although there are larger ''spacing'' differences in ␦ 15 N values (Ϸ3‰) between an organism and its dietary source (9), the isotopic relationships between organism and diet persist. ␦ 13 C, ␦ 15 N, and ␦ 34 S values provide limited geographic-based information about the origins of a food source. Hydrogen (␦ 2 H) and oxygen (␦ 18 O) isotope ratios of organic matter are more useful, because ␦ 2 H and ␦ 18 O values of precipitation and tap waters vary along geographic gradients (10, 11).Although differences in the ␦ 2 H and ␦ 18 O values of scalp hair have been noted in humans (12), less is known about dietorganism patterns of ␦ 2 H and ␦ 18 O values. Four potential sources can be important: dietary organic molecules, dietary waters, drinking waters, and atmospheric diatomic oxygen. Hobson et al.(13) provided evidence that ␦ 2 H values of drinking water were incorporated into different proteinaceous tissues of quail, although no mechanistic basis was proposed for this relationship. The ␦ 2 H values of bird feathers and butterfly wings (both are largely keratin) and water in the region in which the tissue was produced are highly correlated (14, 15). showed that Ϸ70% of the oxygen and Ϸ...

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supporting

confidence: 56%

Hydrogen and oxygen isotope ratios in human hair are related to geography

Ehleringer

Bowen

Chesson

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

329

440

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“…The tissue of a breastfed baby can be respectively enriched by +2-4‰ and 1‰ in 15 N and 13 C during the consumption of the mother's milk (Fogel et al, 1989;Fuller et al, 2006). Other physiological factors related to pathology or stress are also known to increase nitrogen isotope ratios in the consumer's tissue (Katzenberg and Lovell, 1999;Mekota et al, 2006). A moderate consumption of high trophic level proteins can be proposed for the adolescent (Sk2.4, 12-16 years) while the child (Sk9.1, 7-11 years) indicates a higher contribution of marine resources, with non-reef fish.…”

Section: Highlighting Inter-individual Isotope Variabilitymentioning

confidence: 99%

Multi-isotopic analysis of first Polynesian diet (Talasiu, Tongatapu, Kingdom of Tonga)

Herrscher¹,

Fenner²,

Valentin³

et al. 2018

Journal of Archaeological Science: Reports

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A B S T R A C TBoth archaeological and isotopic data document dietary changes over the first five centuries of Western Pacific island settlement, a time period beginning with the Lapita expansion about 3000 years ago. This change is marked by a decrease in marine food intake and an increase in vegetal food intake occurring in the Late Lapita/ immediately post-Lapita populations. The recent discovery of human burials at Talasiu (~2700-2600 cal. BP) in the Kingdom of Tonga opens new opportunities to assess this matter. We characterize the nature of the food items consumed by the Talasiu humans (n = 21) using collagen and apatite carbon and nitrogen stable isotope ratios. We conducted an intra-Pacific comparison to examine the use of marine resources and the contribution of horticultural products and to look at the homogeneity of dietary practices within the Tongan group. Isotope results indicate a mixed diet of terrestrial and marine resources including a differential contribution of more specific marine foods (e.g., non-reef fish/inshore fish and shellfish). The Talasiu dietary pattern appears closer to that of the early Lapita population of Teouma than to other Late Lapita populations suggesting a different pattern of dietary change at the eastern end of the Lapita distribution. The slower rate of change may be due to the small size of both the island and the population, and also the additional potential role of social or cultural factors.

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“…15 N-depleted body tissue proteins are preferentially degraded to obtain amino acids (Hobson and Clark, 1992;Hobson et al, 1993;Fuller et al, 2005;Mekota et al, 2006;Deschner et al, 2012;Vogel et al, 2012). Conversely, a positive nitrogen balance during tissue growth decreases the body tissue d N-depleted animo acids are incorporated into body tissues (Fuller et al, 2004;Waters-Rist and Katzenberg, 2010).…”

Section: N Values Becausementioning

confidence: 99%

Reconstruction of breastfeeding and weaning practices using stable isotope and trace element analyses: A review

Tsutaya

Yoneda

2014

American J Phys Anthropol

193

188

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Biogeochemical methods using stable isotopes and trace elements have been increasingly developed and applied to reconstruct modern and ancient breastfeeding and weaning practices of mammals, including humans, because they offer direct proxies for the dietary intake of subadults. Carbon, nitrogen, and oxygen isotopes have been used to evaluate breast milk lipid, protein, and water intake, respectively. Carbon and sulfur isotopes have been used to estimate the content of weaning foods. The elemental concentrations of Sr and Ba in subadult tissues differ because of the dietary change during the weaning process. For analyses, various tissues have been used, such as hair, nail, blood, and feces for modern mammals and bone and teeth for ancient ones. Of these, trace element analysis of tooth enamel offers a good opportunity for the reconstruction of breastfeeding and weaning practices of the more distant past at finer resolution, although further understanding of the metabolism of trace elements is necessary. There are various tissue-and element-specific advantages and disadvantages, and a combination of different proxies can illuminate practices from various viewpoints. Finally, applying the geochemical reconstruction of breastfeeding and weaning practices to human ecology, primatology, and paleoanthropology is important; basic studies of the underlying physiological mechanisms and technical improvements in the analyses will further highlight avenues for future research. Yrbk Phys Anthropol 156:2-21, 2015. V C 2014 American Association of Physical AnthropologistsThe reconstruction of breastfeeding and weaning practices (BWPs) of ancient human and other mammalian species is one of the most important fields in anthropology, archaeology, evolutionary biology, and history. Infant feeding practices affect the overall health of the population because diet, health status, and growth at a young age have profound effects on an individual's later life (Dettwyler and Fishman, 1992;Katzenberg et al., 1996;WHO, 1998WHO, , 2009Lewis, 2007). Breastfeeding and weaning practices can be viewed from the evolutionary perspectives of life history theory, parental investment, child development, social system, and reproductive strat-

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Serial analysis of stable nitrogen and carbon isotopes in hair: monitoring starvation and recovery phases of patients suffering from anorexia nervosa

Cited by 283 publications

References 39 publications

Hydrogen and oxygen isotope ratios in human hair are related to geography

Hydrogen and oxygen isotope ratios in human hair are related to geography

Multi-isotopic analysis of first Polynesian diet (Talasiu, Tongatapu, Kingdom of Tonga)

Reconstruction of breastfeeding and weaning practices using stable isotope and trace element analyses: A review

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