Serial Alberta Stroke Program Early Computed Tomography Score From Baseline to 24 Hours in SWIFT

Lees, Kennedy R.

doi:10.1161/strokeaha.114.004484

Cited by 1 publication

(1 citation statement)

References 14 publications

(19 reference statements)

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“…However, it has been shown that infarct progression has been seen in patients with reperfusion, despite the absence of hemorrhagic transformation. 15 Factors that may contribute to this are an undetermined duration, usually 1 to 2hours, between the baseline scan and the opening of the artery and a further delay of 16 to 24hours after the outcome angiogram during which unrecognized reocclusion would be possible. 14 When surrogate outcomes were explored, it was found to be clinically relevant and universally applicable to obtain a 24hour or 7day NIHSS in the assessment stroke trial outcomes.…”

Section: Critique/analysismentioning

confidence: 99%

Endovascular Treatment for Acute Ischemic Stroke: IV tPA VS IA tPA

Sheffer¹

2015

PPIJ

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Treatment with intravenous tissue plasminogen activator (IV tPA) alone is associated with an estimated 40% efficacy in early recanalization of major coronary artery (MCA) occlusions. AIS still has almost a 60% rate of mortality or disability in patients treated with IV tPA, despite aggressive therapy. Endovascular treatment is currently being researched. The IA administration of tPA is safe and effective, but remains an unapproved, off-label treatment for AIS. Hypothesized advantages of intra-arterial tPA include direct visualization of acute large vessel thrombi; the ability to customize the tPA dose and location of drug delivery based on features of the individual clot, and potentially more complete thrombolysis. This paper exams the evidence on Intraarterial tPA administration versus IV tPA in patients outside of the 4.5 hr treatment window established by the FDA.

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Section: Critique/analysismentioning

confidence: 99%

Endovascular Treatment for Acute Ischemic Stroke: IV tPA VS IA tPA

Sheffer¹

2015

PPIJ

View full text Add to dashboard Cite

show abstract

Serial Alberta Stroke Program Early Computed Tomography Score From Baseline to 24 Hours in SWIFT

Cited by 1 publication

References 14 publications

Endovascular Treatment for Acute Ischemic Stroke: IV tPA VS IA tPA

Endovascular Treatment for Acute Ischemic Stroke: IV tPA VS IA tPA

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