Serglycin is a novel adipocytokine highly expressed in epicardial adipose tissue

Imoto-Tsubakimoto, Hiroko; Takahashi, Toshifumi; Ueyama, Tomomi; Ogata, Toru; Adachi, Atsuo; Nakanishi, Naohiko; Mizushima, Katsura; Naito, Yuji; Matsubara, Hiroaki

doi:10.1016/j.bbrc.2013.01.078

Cited by 33 publications

(19 citation statements)

References 38 publications

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“…Serglycin secretion can be induced in several cell types upon external inflammatory stimulation. The biosynthesis of serglycin is up-regulated by liposaccharide (LPS) in macrophages (87), tumor necrosis factor (TNF) in endothelial cells (23) and adipocytes (88) and interleukin 1β (IL-1β) in smooth muscle cells (21). …”

Section: Physiological Roles Of Serglycin In Inflammationmentioning

confidence: 99%

“…In a recent study serglycin was found to be among the most abundantly expressed genes in epicardial adipose tissue and was up-regulated with pro-inflammatory genes such as IL-1β, IL-6, IL-8, and chemokine receptor 2 (CCR2) (88). In human umbilical vein endothelial cells (HUVECs) the storage of CXCL1 in secretory vesicles to the apical side was partly depended on serglycin, whereas upon stimulation with IL-1β an increased colocalization of the two molecules inside the vesicles before secretion was observed suggesting a possible involvement of serglycin in inflammatory conditions (22).…”

Section: Physiological Roles Of Serglycin In Inflammationmentioning

confidence: 99%

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Serglycin: At the Crossroad of Inflammation and Malignancy

et al. 2014

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Serglycin has been initially characterized as an intracellular proteoglycan expressed by hematopoietic cells. All inflammatory cells highly synthesize serglycin and store it in granules, where it interacts with numerous inflammatory mediators, such as proteases, chemokines, cytokines, and growth factors. Serglycin is implicated in their storage into the granules and their protection since they are secreted as complexes and delivered to their targets after secretion. During the last decade, numerous studies have demonstrated that serglycin is also synthesized by various non-hematopoietic cell types. It has been shown that serglycin is highly expressed by tumor cells and promotes their aggressive phenotype and confers resistance against drugs and complement system attack. Apart from its direct beneficial role to tumor cells, serglycin may promote the inflammatory process in the tumor cell microenvironment thus enhancing tumor development. In the present review, we discuss the role of serglycin in inflammation and tumor progression.

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Section: Physiological Roles Of Serglycin In Inflammationmentioning

confidence: 99%

Section: Physiological Roles Of Serglycin In Inflammationmentioning

confidence: 99%

Serglycin: At the Crossroad of Inflammation and Malignancy

et al. 2014

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“…It was also demonstrated that tumour necrosis factor-alpha (TNF-a) induces expression and secretion of serglycin in adipocytes. These observations suggest that serglycin and TNF-a probably contribute to the development and progression of CAD through cross-talk between macrophages and adiposities [20].…”

Section: Discussionmentioning

confidence: 82%

Association of serglycin levels with isolated coronary artery ectasia

et al. 2017

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A b s t r a c tBackground: Serglycin plays an important role in the inflammatory status, but the relationship between coronary artery ectasia (CAE) and serglycin is still unknown. Aim:In this study, we aimed to investigate the association of serglycin level with isolated CAE. Methods:Fifty-two patients with isolated CAE and 35 individuals with normal coronary angiography were included into the study. The Markis classification and number of ectatic coronary arteries were recorded. Plasma serglycin levels were measured. Results:Multivariate logistic regression analysis revealed that serglycin and high-sensitivity C-reactive protein were independently associated with the presence of CAE. In receiver operating characteristics curve analysis the cut of serglycin level for the prediction of isolated CAE was 13.5, with a sensitivity of 88.5% and a specificity of 84.8%. However, there was no association between serglycin levels and Markis classification. Conclusions:Serglycin levels are significantly and independently higher in patients with CAE.

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“…However, quite interestingly, eAT exhibited another layer of depot specificity with an overrepresentation of immune, in particular, T cell-associated processes from activation and differentiation to apoptosis, relative to both mAT and sAT. Indeed, an upregulation in the expression of 55 genes associated with inflammation in human eAT relative to omental adipose tissue has been reported before (20). However, a previous study directly comparing eAT, mAT, and sAT using whole-genome microarrays (n = 6) did not observe much distinction in eAT and mAT, finding both of them to overexpress inflammatory signals relative to sAT (19).…”

Section: Discussionmentioning

confidence: 83%