Serepidemiology of Hepatitis B and D Virus Infection among Intravenous Drug Addicts in Israel

Dan, Michael; Rock, Meir; Lilos, Pearl; Shany, Shulamit Bar

doi:10.1093/ije/22.1.140

Cited by 8 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cohort included in this study consisted of hospitalized patients and might, therefore, not represent a true prevalence of HDV infection in Lebanon. Of interest, our results are in contrast to the situation in neighbouring Arab [16][17][18] and non-Arab countries in the Mediterranean region [19][20][21]. For example, anti-HDV positivity was reported in 8 .…”

Section: Resultscontrasting

confidence: 99%

Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon

et al. 2006

View full text Add to dashboard Cite

Recently the prevalence of hepatitis B virus (HBV) genotypes and the association between these genotypes and the clinical status of HBV-infected patients were recently investigated in the Lebanese population. The aim of the additional study reported here was to determine the current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in this Lebanese population. Two hundred and fifty-eight HBsAg-positive patients (107 asymptomatic blood donors, 92 with chronic hepatitis, 24 with cirrhosis, 15 with hepatocellular carcinoma, 20 patients on haemodialysis) from ten medical centers in Lebanon were tested for antibody to hepatitis D virus (anti-HDV). Those testing positive were analysed further for HDV-RNA and for genotyping by reverse transcriptase-polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP). Three samples (1.2%) were anti-HDV positive and out of these, only one was HDV-RNA positive (0.6%) and was analysed as HDV genotype I. Our results point to a low endemicity of HDV in the Lebanese population which is in sharp contrast to data reported from Lebanon 20 years ago and to the situation in neighbouring Arab and non-Arab countries in the Mediterranean region. HDV genotype I seems to be the predominant genotype in Lebanon and the Middle East.

show abstract

Section: Resultscontrasting

confidence: 99%

Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon

et al. 2006

View full text Add to dashboard Cite

show abstract

“…The frequency of HBsAg found in this study (7.8%) is comparable with that observed in areas of high endemicity, with more than 8% of HBsAg prevalence, and agrees with results from other studies of IDUs in Santos, SP, Brazil (18), and in other countries (9). HBV infection was significantly associated with male ho- mosexual intercourse, but no association with parenteral exposure variables was found.…”

Section: Discussionsupporting

confidence: 91%

“…This profile is remarkable since even in areas of low endemicity for HDV, 17-98% of HbsAg-positive IDUs present HDV antibodies (9).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, these subjects play a role as a reservoir and source of viral transmission in the inter-and extra-exposure categories. The prevalence of blood-borne hepatitis is usually higher among IDU than in other comparable non-IDU population strata (9). Epidemiological data indicate that IDUs represent the largest risk group for HCV infection (10).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and risk factors for HBV, HCV and HDV infections among injecting drug users from Rio de Janeiro, Brazil

Oliveira

Bastos

Telles

et al. 1999

Braz J Med Biol Res

View full text Add to dashboard Cite

Viral hepatitis constitutes a major health issue, with high prevalence among injecting drug users (IDUs). The present study assessed the prevalence and risk determinants for hepatitis B, C and D viruses (HBV, HCV and HDV) infections among 102 IDUs from Rio de Janeiro, Brazil. Serological markers and HCV-RNA were detected by enzyme immunoassay and nested PCR, respectively. HCV genotyping was determined by restriction fragment length polymorphism analysis (RFLP). HBsAg, anti-HBc and anti-HBs were found in 7.8, 55.8 and 24.7% of IDUs, respectively. In the final logistic regression, HBV infection was independently associated with male homosexual intercourse within the last 5 years (odds ratio (OR) 3.1; 95% confidence interval (CI) 1.1-8.8). No subject presented anti-delta (anti-HD). Anti-HCV was detected in 69.6% of subjects, and was found to be independently associated with needle sharing in the last 6 months (OR 3.4; 95% CI 1.3-9.2) and with longer duration of iv drug use (OR 3.1; 95% CI 1.1-8.7). These data demonstrate that this population is at high risk for both HBV and HCV infection. Among IDUs from Rio de Janeiro, unprotected sexual intercourse seems to be more closely associated with HBV infection, whereas HCV is positively correlated with high risk injecting behavior. Comprehensive public health interventions targeting this population and their sexual partners must be encouraged.

show abstract

“…The prevalence of blood-borne hepatitis is usually higher among IDU than in other comparable non-IDU population strata. [9] Epidemiological data indicate that IDUs represent the largest risk group for HCV infection. [10] The aim of the present study was to assess the frequency of HBV, HCV, and HIV infections and their respective risk factors among IDUs from.…”

Section: Introductionmentioning

confidence: 99%

Frequency of HBV, HCV and HIV infections among hospitalized injecting drug users in Kashan

Sharif

Sherif

Sayyah

2009

Indian J Sex Transm Dis

View full text Add to dashboard Cite

Context:Infectious diseases including HIV and viral hepatitis constitute a major health issue, with high prevalence among injecting drug users (IDUs).Aims:The present study assessed the frequency of HIV, and hepatitis B and C viruses (HBV and HCV) among 200 IDUs, hospitalized between 2001 and 2006, in Shahid Beheshti Hospital of Kashan, Iran.Setting and Design:A population-based cross-sectional study in Iran.Materials and Methods:A total of 200 subjects participated in this study. Serological markers including HBsAg, anti-HCV antibodies and HIV were assessed by ELISA method using Monobid kits made in US. Demographic data was collected by using a questionnaire, which was designed by a researcher.Statistical Analysis Used: Frequencies were determined by employing SPSS:PC version 15.0, and Chi-square and Fisher's exact tests were used to compare proportions.Results:The mean age of subjects was 36.5 ± 10.2 years. Approximately 88.5% (177 cases) were male and 11.5%. (23 cases) were female. The frequency of positive infection test results for males with respect to HBV, HCV, and HIV was 4% (8 cases), 10.5% (21 cases), and 1.5% (3 cases); and for females it was 0.5% (1 case), 1.5% (3 cases), and 0% (0 case), respectively.Conclusion:This study demonstrates that the frequency of HBV, HCV, and HIV infection in the IVD user in Kashan, Iran, is relatively high and this condition is more serious in male than female drug addicts. It is very important, especially for health providers and policy makers, to recognize the risk factors of HBV, HCV and particularly HIV infection in this area and design effective preventive programs.

show abstract

Serepidemiology of Hepatitis B and D Virus Infection among Intravenous Drug Addicts in Israel

Cited by 8 publications

References 0 publications

Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon

Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon

Prevalence and risk factors for HBV, HCV and HDV infections among injecting drug users from Rio de Janeiro, Brazil

Frequency of HBV, HCV and HIV infections among hospitalized injecting drug users in Kashan

Contact Info

Product

Resources

About