Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement

Franco, Juan VA; Trivisonno, Leonel Fabrizio; Sgarbossa, Nadia; Alvez, Gustavo Ariel; Fieiras, Cecilia; Liquitay, Camila Micaela Escobar; Jung, Jae Hung

doi:10.1002/14651858.cd001423.pub4

Cited by 4 publications

(2 citation statements)

References 130 publications

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“…The full methods of this review, including the full search strategy, can be found in the published version at the Cochrane Library [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Serenoa repens for the Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Enlargement: An Updated Cochrane Review

Franco,

Trivisonno,

Sgarbossa

et al. 2024

World J Mens Health

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Purpose To assess the effects of Serenoa repens in the treatment of men with lower urinary tract symptoms (LUTS) consistent with benign prostatic hyperplasia (BPH). Materials and Methods We performed a comprehensive search using multiple databases up to September 2022 with no language or publication status restrictions. We included parallel-group randomized controlled trials of participants with BPH who were treated with Serenoa repens or placebo/no treatment. We used standard Cochrane methods, including a GRADE assessment of the certainty of the evidence (CoE). Results We included 27 studies involving a total of 4,656 participants. Serenoa repens results in little to no difference in urologic symptoms at short-term follow-up (International Prostate Symptom Score [IPSS]: mean difference [MD] −0.90, 95% confidence interval [CI] −1.74 to −0.07; I 2 =68%; 9 studies, 1,681 participants; high CoE). Serenoa repens results in little to no difference in the quality of life at short-term follow-up (high CoE). Serenoa repens probably results in little to no difference in adverse events (moderate CoE). Different phytotherapeutic agents that include Serenoa repens may result in little to no difference in urologic symptoms compared to placebo at short-term follow-up (IPSS: MD −2.41, 95% CI −4.54 to −0.29; I 2 =67%; 4 studies, 460 participants; low CoE). We are very uncertain about the effects of these agents on quality of life (very low CoE). These agents may result in little to no difference in the occurrence of adverse events (low CoE). Conclusions Serenoa repens alone provides little to no benefits for men with LUTS due to benign prostatic enlargement. There is more uncertainty about the role of Serenoa repens in combination with other phytotherapeutic agents.

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“…The full methods of this review, including the full search strategy, can be found in the published version at the Cochrane Library [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Serenoa repens for the Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Enlargement: An Updated Cochrane Review

Franco,

Trivisonno,

Sgarbossa

et al. 2024

World J Mens Health

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“…HESr had no significant sexual dysfunction associated with its use and overall was well tolerated with gastrointestinal disorders being the most common side effect in 3.8% of men [44]. A more recent meta-analysis, although not looking specifically at HESr, compared Serenoa repens with placebo reported a minimal improvement in IPSS associated with Serenoa repens at 3-6 months although this was not deemed to be of clinical significance [45]. Ultimately, current evidence suggests that any improvement in LUTS due to BPO from taking HESr is likely to be modest at best, although the side-effect profile is favourable regarding sexual function and some men may choose to consider HESr provided they are prepared to accept the limited efficacy [9].…”

Section: Supplementsmentioning

confidence: 99%

Treatment Algorithm for Management of Benign Prostatic Obstruction: An Overview of Current Techniques

Hughes,

Harper,

Somani

2023

Life

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The management of benign prostatic obstruction (BPO) should involve a treatment algorithm that takes into account prostate size, and patient’s symptoms and preference with the aim of helping with urinary symptoms and enhance quality of life. The diagnostic assessment for men with lower urinary tract symptoms (LUTS) should be comprehensive to help choose the best management strategy. Strategies from lifestyle modifications to medical treatment with alpha blockers and/or 5-alpha-reductase inhibitors to surgical procedures can all be used in the management algorithm. Surgical management ranges from transurethral resection of prostate (TURP) to minimally invasive surgical therapies (MIST) including laser therapies such as Holmium laser enucleation (HoLEP) and photoselective vaporisation (PVP), aquablation, Rezūm system, prostate artery embolisation (PAE), prostatic urethral lift (PUL), temporary implantable nitinol device (iTind) and Optilume BPH catheter system. BPO is a common urological condition that has a significant impact on quality of life and economic burden globally and is likely to become increasingly prevalent with an ageing population. Selecting the most appropriate treatment modality will depend on the individual patient preferences, availability of resources, cost, anatomical factors and the goals of treatment.

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For men with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH), does Serenoa repens help improve outcomes?

Tort,

Husein-ElAhmed

2023

Cochrane Clinical Answers

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Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement

Cited by 4 publications

References 130 publications

Serenoa repens for the Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Enlargement: An Updated Cochrane Review

Serenoa repens for the Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Enlargement: An Updated Cochrane Review

Treatment Algorithm for Management of Benign Prostatic Obstruction: An Overview of Current Techniques

For men with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH), does Serenoa repens help improve outcomes?

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