Serenoa repens extract additionally to quinolones in the treatment of chronic bacterial prostatitis. The preliminary results of a long term observational study

Stamatiou, Konstantinos; Pierris, Nikolaos

doi:10.4081/aiua.2013.4.190

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Currently, α-blockers represent the first-choice treatment for LUTS in patients diagnosed with both prostatitis and benign prostate hyperplasia (BPH) [6]. On the other hand, traditional herbal extracts were efficacious in controlling the inflammatory component associated with these disorders [7][8][9][10], with the efficacy that could be improved through their pharmacological associations [11]. This is consistent, at least in part, with the scientific literature suggesting the benefits of the combination of herbal extracts, usually employed as food supplements, for treating chronic inflammatory diseases [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Content and Antimicrobial and Anti-Inflammatory Effects of Solidago virga-aurea, Phyllanthus niruri, Epilobium angustifolium, Peumus boldus, and Ononis spinosa Extracts

et al. 2020

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Prostatitis is an inflammatory condition that is related to multiple infectious agents, including bacteria and fungi. Traditional herbal extracts proved efficacious in controlling clinical symptoms associated with prostatitis. In this context, the aim of the present study was to explore the efficacy of extracts from Solidago virga-aurea, Ononis spinosa, Peumus boldus, Epilobium angustifolium, and Phyllanthus niruri against bacterial (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus) and fungi strains (Candida albicans; C. tropicalis) involved in prostatitis. Additionally, anti-mycotic effects were tested against multiple species of dermatophytes (Trichophyton rubrum, T. tonsurans, T. erinacei, Arthroderma crocatum, A. quadrifidum, A. gypseum, A. currey, and A. insingulare). Antioxidant effects were also evaluated in isolated rat prostates challenged with lipopolysaccharide (LPS), and phytochemical analyses were conducted to identify and quantify selected phenolic compounds, in the extracts. Finally, a bioinformatics analysis was conducted to predict putative human and microbial enzymes targeted by extracts’ phytocompounds and underlying the observed bio-pharmacological effects. The phytochemical analysis highlighted that rutin levels could be crucial for explaining the highest antibacterial activity of P. boldus extract, especially against E. coli and B. cereus. On the other hand, in the E. angustifolium extract, catechin concentration could partially explain the highest efficacy of this extract in reducing lipid peroxidation, in isolated rat prostates stimulated with LPS. Concluding, the results of the present study showed moderate antimicrobial and anti-inflammatory effects induced by water extracts of S. virga-aurea, P. boldus, E. angustifolium, P. niruri, and O. spinosa that could be related, at least partially, to the phenolic composition of the phytocomplex.

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Section: Introductionmentioning

confidence: 99%

Phenolic Content and Antimicrobial and Anti-Inflammatory Effects of Solidago virga-aurea, Phyllanthus niruri, Epilobium angustifolium, Peumus boldus, and Ononis spinosa Extracts

et al. 2020

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“…In Korea, as well as other Asian countries, natural products have been used for the treatment of various diseases since ancient times. As natural products are composed of an assortment of natural substances rather than a single substance, they can exhibit a wide range of efficacies owing to the combined effect of various ingredients; additionally, the effects may vary depending on the blending ratio or the extraction method …”

Section: Introductionmentioning

confidence: 99%

Protection Effect of Cyanidin 3‐O‐Glucoside Against Oxidative Stress‐induced HepG2 Cell Death Through Activation of Akt and Extracellular Signal‐regulated Kinase Pathways

Park

Kang

Lee

2017

Bulletin Korean Chem Soc

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The attack of reactive oxygen species (ROS) on unsaturated fatty acids causes peroxidation. The membranes of liver cells are rich in unsaturated fatty acids, which are a target of lipid peroxidation by free radicals. The purpose of the present study was to identify the hepatoprotective potential of Lonicera caerulea and its active compound, cyanidin 3‐O‐glucoside, on tertiary butyl hydroperoxide (tBHP)‐induced oxidative damage in HepG2 cells. L. caerulea extract and its active compound, cyanidin 3‐O‐glucoside, showed a dose‐dependent hepatoprotective effect on tBHP‐induced HepG2 cell damage. In addition, L. caerulea and cyanidin 3‐O‐glucoside inhibited the production of intracellular ROS in tBHP‐treated HepG2 cells. The protein expression of phosphorylated‐extracellular signal‐regulated kinases and Akt, which are responsible for cell protection against ROS, were increased after treatment with cyanidin 3‐O‐glucoside (50 and 100 μM) in a dose‐dependent manner. Therefore, cyanidin 3‐O‐glucoside is the active compound in L. caerulea, which is responsible for the hepatoprotective effects through the inhibition of ROS and the activation of antioxidant mechanisms.

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Serenoa repens (Saw Palmetto)

Abascal¹,

Yarnell²

2020

Textbook of Natural Medicine

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Serenoa repens extract additionally to quinolones in the treatment of chronic bacterial prostatitis. The preliminary results of a long term observational study

Abstract: Serenoa repens extract for 8 weeks seems to improve prostatitis related pain. Further randomized, placebo-controlled studies are needed to substantiate safer conclusions.

Cited by 8 publications

References 11 publications

Phenolic Content and Antimicrobial and Anti-Inflammatory Effects of Solidago virga-aurea, Phyllanthus niruri, Epilobium angustifolium, Peumus boldus, and Ononis spinosa Extracts

Phenolic Content and Antimicrobial and Anti-Inflammatory Effects of Solidago virga-aurea, Phyllanthus niruri, Epilobium angustifolium, Peumus boldus, and Ononis spinosa Extracts

Protection Effect of Cyanidin 3‐O‐Glucoside Against Oxidative Stress‐induced HepG2 Cell Death Through Activation of Akt and Extracellular Signal‐regulated Kinase Pathways

Serenoa repens (Saw Palmetto)

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