SERCA2a: its role in the development of heart failure and as a potential therapeutic target

Fragoso-Medina, Jorge; Zarain‐Herzberg, Ángel

doi:10.2147/rrcc.s38614

Cited by 1 publication

(2 citation statements)

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“…The lower cardiac contractility indexes (LVDP, RPP, and ± dP/dt), could be illustrated through reduced SERCA2a expression. 45 Further, GA increased the low expression of SERCA2a induced by I/R injury in the heart tissue. These results indicated that GA could improve cardiac performance by enhancing SERCA2a gene expression in hypertrophic hearts induced by ISO in I/R injury conditions for the first time.…”

Section: Discussionmentioning

confidence: 96%

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Gallic acid protects against isoproterenol-induced cardiotoxicity in rats

et al. 2022

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Background Gallic acid (GA) is a polyphenolic agent with interesting pharmacological impacts on the cardiovascular system. Objective The present study purposed to study the protective effects of GA at 25 and 50 mg/kg against isoproterenol (ISO)-induced cardiac damage in ischemia/reperfusion (I/R) in rats. Methods Male Wistar rats were randomly assigned into six groups: Control, Control treated with GA at 25 mg/kg (GA25), Control treated with GA at 50 mg/kg (GA50), Hypertrophic rats induced by ISO (ISO), Hypertrophic rats treated with GA at 25 mg/kg (ISO+GA25), and Hypertrophic rats treated with GA at 50 mg/kg (ISO+GA50). Heart isolation was performed to induce a cardiac I/R injury model. Cardiac hemodynamic parameters were recorded. Serum Lactate Dehydrogenase (LDH) and Creatine Kinase-MB (CK-MB) and cardiac Superoxide dismutases (SOD) levels were evaluated. The gene expression of Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) was assessed. Results We found that GA at 50 mg/kg was significantly increased cardiac function at post I/R period in ISO-induced hypertrophic hearts. Moreover, it suppressed cardiac hypertrophy, the serum LDH and CK-MB levels in ISO injected rats. Administration of GA at 50 mg/kg was significantly increased SOD level and SERCA2a gene expression in the hypertrophic hearts. Conclusion GA at 50 mg/kg could improve cardiac performance possibly by increasing antioxidant defense enzymes, reducing cell damage, and enhancing SERCA2a gene expression in hypertrophic heart induced by ISO in I/R injury conditions.

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Section: Discussionmentioning

confidence: 96%

“…LDH and CK-MB levels in the serum were significantly enhanced in the ISO injected rats compared with the control rats (7726. 45…”

Section: Impacts Of Ga On Ldh and Ck-mb Valuesmentioning

confidence: 99%