Serbian Twin Registry

Smederevac, Snežana; Mitrović, Dušanka; Sadiković, Selka; Milovanović, Ilija; Branovački, Bojan; Dinić, Bojana M.; Nikolašević, Željka; Kodžopeljić, Jasmina; Ignjatović, Vojislava Bugarski; Semnic, Marija; Stankov, Tijana Vujanić; Vučinić, Nataša; Oljača, Milan; Pajić, Dejan; Stojadinović, Aleksandra; Krstić, Tatjana; Milutinović, A.

doi:10.1017/thg.2019.114

Cited by 14 publications

(11 citation statements)

References 31 publications

(29 reference statements)

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“…The Serbian Twin Registry includes data on 1,654 participants. The procedure for collecting data from twins is described elsewhere (Smederevac et al, 2019). Participants in this study were 316 MZ and 162 DZ twins raised together (478 in total; see Table 1).…”

Section: Participants and Data Collectionmentioning

confidence: 99%

Twin study of laboratory‐induced aggression

Dinić

Smederevac

Sadiković

et al. 2020

Aggressive Behavior

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The aim of this study was to explore genetic and environmental contributions to laboratory-induced aggressive behavior. On a sample of 478 adult twins (316 monozygotic), the Competitive Reaction Time Task was used for aggression induction. The results showed that the initial, basic level of aggression could be explained by both shared (45%) and nonshared environmental factors (55%), while only nonshared environmental factors (100%) had a significant influence on changes in aggression as provocation increased. Genetic factors had no influence on laboratoryinduced aggression. The results highlight the importance of environmental factors in shaping situation-specific aggressive responses to provocation.

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Section: Participants and Data Collectionmentioning

confidence: 99%

Twin study of laboratory‐induced aggression

Dinić

Smederevac

Sadiković

et al. 2020

Aggressive Behavior

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“…The Serbian Twin Registry has data on 1654 participants. The entire procedure for testing and collecting data is described elsewhere (Smederevac et al, 2019 ). Participation was voluntary and participants signed informed consent.…”

Section: Methodsmentioning

confidence: 99%

Quantitative behavioral genetic and molecular genetic foundations of the approach and avoidance strategies

et al. 2022

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Two studies examined genetic and environmental influences on traits proposed by the revised Reinforcement Sensitivity Theory (rRST) of personality. Both quantitative and molecular behavioral genetic methods were applied considering the effects of COMT , DRD2 , HTR1A and TPH2 single nucleotide polymorphisms (SNPs). Study one included 274 monozygotic and 154 dizygotic twins for the quantitative behavioral study; and in study two there were 431 twins for the molecular genetic study. The Reinforcement Sensitivity Questionnaire was used to assess basic personality traits defined by the rRST. Univariate biometric modeling suggested that genetic influences accounted for 34–44% of variance of Behavioral Approach System (BAS), Behavioral Inhibition System (BIS) and Fight-Fligh-Freeze System. Molecular genetic analyses proposed the significant main effect of COMT SNP on the BAS and TPH2 SNP on the BIS, and pointed out epistatic effects of COMT x DRD2 on BAS and HTR1A x TPH2 on Fight. Results demonstrated substantial heritability for all rRST constructs, as well as for differences in the molecular genetic basis of both approach-related and avoidance-related dimensions.

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“…The participation of the twins was voluntary, and each respondent signed an informed consent for participation. EFs were examined by trained researchers and the entire procedure for collecting data is described elsewhere (see Smederevac et al, 2019 for detailed recruitment procedures).…”

Section: Methodsmentioning

confidence: 99%

“…The sample was drawn from the Serbian Twin Registry (see Smederevac et al, 2019 for detailed recruitment procedures), a national and multidisciplinary twin database. The Serbian Twin Registry sample consists of 1,654 participants, including twin pairs and their family members.…”

Section: Sample and Proceduresmentioning

confidence: 99%

Latent, genetic, and molecular genetic structure of the Wisconsin Card Sorting Test.

Nikolašević¹,

Ignjatović²,

Kodžopeljić³

et al. 2022

Neuropsychology

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Objective: The main goal of this study was to explore the latent structure and genetic basis of cognitive processes involved in the Wisconsin Card Sorting Task (WCST) within phenotypic, behavioral genetic, and molecular genetic research paradigms. Method: The sample used in phenotypic and behavioral genetic analyses comprised 468 twins (154 monozygotic and 80 dizygotic twin pairs), while molecular genetic analyses were performed on 404 twins from the same sample. The zygosity of most twin pairs (96.8%) was determined via deoxyribonucleic acid (DNA) analysis of buccal swabs. Trained researchers administered the Wisconsin Card Sorting Test (WCST; Heaton et al., 1993) to the entire sample. Results: A phenotypic factor analysis of WCST variables suggested a single-factor solution. Overall heritability ranged from 0.19 to 0.23 across different measures of the WCST. The presence of a single general genetic factor, which could be identified from different measures of the WCST, indicated the unity of various WCST indicators and the existence of a common basic ability. Performance on the WCST did not reveal significant differences between the three genotypes on catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2). Carriers of the brain-derived neurotrophic factor (BDNF) Met+ genotype exhibited better performance in cognitive functions in comparison to the BDNF Met− genotype. Conclusions: This study highlighted similarities in the phenotypic and genetic structures of the WCST, suggesting one general factor underlying different cognitive functions. The BDNF Met+ genotype showed significant main effects on different WCST measures.

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Serbian Twin Registry

Cited by 14 publications

References 31 publications

Twin study of laboratory‐induced aggression

Twin study of laboratory‐induced aggression

Quantitative behavioral genetic and molecular genetic foundations of the approach and avoidance strategies

Latent, genetic, and molecular genetic structure of the Wisconsin Card Sorting Test.

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