Sera antioxidant activity in uncomplicated and preeclamptic pregnancies

Davidge, Sandra T.; Hubel, Carl A.; Brayden, R.D.; Capeless, EL; McLaughlin, Margaret K.

doi:10.1016/0020-7292(93)90421-r

Cited by 82 publications

(67 citation statements)

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“…In some previous clinical studies, the increase of LPX intensity was observed in plasma of women with complications in the course of their pregnancies (Davidge et al 1992;Kharb et al 1998;Mutlu-Türkoglu et al 1998). Other authors found that spontaneous delivery caused the increase of LPX products levels in plasma of newborns in comparison to those delivered by caesarean section (Rogers et al 1998).…”

Section: Resultsmentioning

confidence: 84%

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Lipid peroxidation and biochemical parameters in maternal pre-delivery and post-delivery plasma

et al. 2010

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Lipid peroxidation (LPX) can play an important role in development of functional and pathological changes of maternal tissues in the course of pregnancy and delivery. LPX products were measured as thiobarbituric acid reacting substances (TBARS), using malondialdehyde as the standard solution. Actual TBARS determined in maternal post-delivery plasma (2.71 ± 0.602 nmol/mL) were not statistically different from those determined in pre-delivery plasma (3.45 ± 0.530 nmol/mL). TBARS production was measured in vitro in the both incubated plasma (30 min, 37• C) with and without the added LPX activator (125 µM L-ascorbate plus 5 µM FeSO4). A difference in the TBARS formation was found only in the post-delivery plasma, as a result of approximately twice higher (marginally significant) TBARS formation in the incubated plasma without the added LPX activator comparing with the actual TBARS levels in this plasma. These results suggest that changes in maternal tissues in the process of labour could create suitable conditions for activation of LPX in maternal plasma. On the other hand, all other analysed biochemical parameters (iron, total iron-binding capacity, uric acid, proteins, magnesium, calcium, phosphate, glucose, potassium, sodium, chlorides, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, creatine kinase, lactate dehydrogenase, α-hydroxybutyrate dehydrogenase, α-amylase, alkaline phosphatase, acid phosphatase in the post-delivery plasma were not different from those analysed in the pre-delivery plasma.

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Section: Resultsmentioning

confidence: 84%

“…The perinatal period represents a significant oxidative stress for foetus (Žitňanová et al 2004;Brucknerová et al 2005). The potential damage of cells that can be caused by free radicals is physiologically minimized by antioxidant systems that serve to control peroxidation (Davidge et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation and biochemical parameters in maternal pre-delivery and post-delivery plasma

et al. 2010

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“…But the balance disorder between lipid peroxidation and antioxidants with oxidative stress has increased (Atamer et al, 2005;El-Salahy et al, 2001;Gupta et al, 2005). It is reported that the index of oxidative stress has increased significantly (Davidge et al, 1992).…”

Section: Resultsmentioning

confidence: 99%

Paraoxonase activity an indicator of complications at early stage of complicated pregnant cows

NazliErcan

Yokuş

Kochan

2017

IJAR

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In healthy and complicated pregnant cows, on the 2 nd and 6 th months of pregnancy in order to determine the levels of maternal serum Paraoxonase 1 (PON1) activity and the possibility of complications can occur during the pregnancy might be a premise indication. Serum samples were taken at 2 nd and 6 th months of 252 pregnant cows at the end of their pregnancies. The cows were classified into two groups such as complicated (Abortion, Dystocia) and non-complicated. Maternal serum PON1 activity in 6 th months was lower at complicated group than normally pregnant group (P=0.004; P<0.01), no difference was discovered between these groups in their 2 nd month of pregnancy (P>0.05). Among the concentration of HDL, TP and globulin no statistical difference was observed between complicated, subgroups and normal births (P>0.05). Levels of PON1 in 2 and 6 months were statistically different between the groups of dystocia and normal pregnancy (P<0.01; P = 0.003), and abort and normal pregnancy (P<0.05; P=0.033). In this study, it was inferred that the evaluation of PON1 activity early indicator of complications for clinicians that might occur in further periods of pregnancy. These results showed the fact that PON1 activity can be used as a marker relatively at the early phases of pregnancy in complicated cows.

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“…Serum MDA levels were significantly increased in PIH, preeclampsia and eclampsia compared to normal third trimester pregnant women. Jain SK and Wise R 13 20 found that antioxidant activity was markedly reduced in preeclampsia. The excessive generation of free radicals inactivates the enzymes system in the body leading to decreased SOD activity observed in present study.…”

Section: Discussionmentioning

confidence: 99%

Compprative Study of Oxidative Stress in Pregnancy Induced Hypertension Preeclampsia and Eclampsia

Sheena¹

2012

Int J of Biomed & Adv Res

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Background and Objective: A Hypertensive disorder of pregnancy is an important cause of maternal mortality and preeclampsia. The present study is centered on the concept that a derangement if any, in the oxidant antioxidant equilibrium during Pregnancy Induced Hypertension, Preeclampsia and Eclampsia. Materials and Methods: Defined groups of Pregnancy Induced Hypertension, Pre-eclampsia and eclampsia patients were selected with written informed consent with fifty subjects in each group. Blood sample was collected by venous puncture and centrifuged to get serum. The estimation of Malondialdehyde, Superoxide dismutase and catalase in three different groups was done using standard spectrophotometric method. The data were expressed as Mean ± SD. Comparison of oxidative stress between patients and controls was performed using unpaired' rest. P value less than 0.05 was considered significant. Results: The level of MDA was e significantly increased in (P<0.001) in PIH group but, the level of SOD and Catalase was significantly less (P<0.01). The level of MDA and Catalase in preeclampsia was significantly increased (P<0.001) but, the activity of SOD was decreased significantly (P<0.001). Similarly, in preeclampsia and Eclampsia group. When the serum MDA and catalase activity in erythrocytes and SOD level in PIH, Preeclampsia and Eclampsia were compared with normal group has shown a significant increase (P<0.001) in MDA and Catalase but significant decline (P<0.001) in SOD level respectively in all the groups. Conclusion: In PIH, Preeclampsia and Eclampsia there is an imbalance between lipid peroxides and the antioxidant system.

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Sera antioxidant activity in uncomplicated and preeclamptic pregnancies

Cited by 82 publications

References 0 publications

Lipid peroxidation and biochemical parameters in maternal pre-delivery and post-delivery plasma

Lipid peroxidation and biochemical parameters in maternal pre-delivery and post-delivery plasma

Paraoxonase activity an indicator of complications at early stage of complicated pregnant cows

Compprative Study of Oxidative Stress in Pregnancy Induced Hypertension Preeclampsia and Eclampsia

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