Ser-Leu substitution at P2 position of the hemagglutinin cleavage site attenuates replication and pathogenicity of Eurasian avian-like H1N2 swine influenza viruses

The evolution, pathogenicity and transmissibility of quadruple reassortant H1N2 swine influenza virus in China: A potential threat to public health

“…Additionally, the results of this study indicated that some viruses could replicate effectively in the spleen and kidney. A recent study found that substituting S328L at the hemagglutinin cleavage site of an EA-like H1N2 swine influenza virus reduced weight loss and increased survival in mice ( Cai et al., 2021 ; Jung et al., 2020 ). In our study, all five SIVs had the S328L mutation at the HA cleavage sites, which may explain why the isolated strains exhibited lower pathogenicity.…”