Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition

Fan, Jialong; Liu, Bin; Long, Ying; Zhou, Wang; Tong, Chunyi; Wang, Wei; You, Peidong; Liu, Xuanming

doi:10.1016/j.actbio.2020.06.025

Cited by 53 publications

(45 citation statements)

References 42 publications

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“…Rahmani et al reported that Dox-Conferone loaded micelles led to 95% apoptosis in MDA-MB-231 cells 6 . According to Fan et al Dox-Gamabufotalin loaded NPs induced about 79–89.2% apoptosis to MDA-MB-231 cells 61 . In comparison to the recent literature, our developed Dox-Conf loaded β CD-g-PMA-co-PLGA micelles showed superior performance in induction of apoptosis in MDA-MB-231 cells.…”

Section: Resultsmentioning

confidence: 97%

“…Li et al , using western blotting, reported that Dox-Oridonin combination induced apoptosis to MDA-MB-231 cells via Bcl-2/Bax, cleaved-caspase-3 and cleaved-PARP pathway 60 . Fan et al showed that combination of Dox with Gamabufotalin induced apoptosis to MDA-MB-231 cells via p53, Bcl-2/Bax and cleaved-caspase-3 root 61 . Sabzi et al reported that Dox-curcumin loaded micelles induced apoptosis to MDA-MB-231 cells via Bcl-2/Bax, cleaved-caspase-9, cleaved-caspase-7, cleaved-caspase-3 and p27 3 .…”

Section: Resultsmentioning

confidence: 99%

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Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells

Rahmani

Rahimi

Iranshahi

et al. 2021

Sci Rep

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Adjuvant-aided combination chemotherapy is one of the most effective ways of cancer treatment by overcoming the multidrug resistance (MDR) and reducing the side-effects of anticancer drugs. In this study, Conferone (Conf) was used as an adjuvant in combination with Doxorubicin (Dox) for inducing apoptosis to MDA-MB-231 cells. Herein, the novel biodegradable amphiphilic β-cyclodextrin grafted poly maleate-co-PLGA was synthesized by thiol-ene addition and ring-opening process. Micelles obtained from the novel copolymer showed exceptional properties such as small size of around 34.5 nm, CMC of 0.1 μg/mL, and cell internalization of around 100% at 30 min. These novel engineered micelles were used for combination delivery of doxorubicin-conferone with high encapsulation efficiency of near 100% for both drugs. Our results show that combination delivery of Dox and Conf to MDA-MB-231 cells had synergistic effects (CI < 1). According to cell cycle and Annexin-V apoptosis analysis, Dox-Conf loaded micelle significantly induce tumor cell apoptosis (more than 98% of cells population showed apoptosis at IC50 = 0.259 μg/mL). RT-PCR and western-blot tests show that Dox-Conf loaded βCD-g-PMA-co-PLGA micelle induced apoptosis via intrinsic pathway. Therefore, the unique design of multi-functional pH-sensitive micelles open a new perspective for the development of nanomedicine for combination chemo-adjuvant therapy against malignant cancer.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells

Rahmani

Rahimi

Iranshahi

et al. 2021

Sci Rep

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“…3 Department of Breast Surgery, The First People's Hospital of Foshan, Sun Yat-Sen University, Guangdong, China. 4 Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.…”

Section: Declarationsmentioning

confidence: 99%

“…Innovative new therapies are still needed, especially for patients with poorly treated breast cancer, such as those with triple-negative breast cancer and metastatic breast cancer. The development of nanomedicines has brought new perspectives to the treatment of cancer [4]. Among the several kinds of nanoparticles (NPs), graphene-based nanomaterials (GBNs) stand out due to their unique chemical structures.…”

Section: Introductionmentioning

confidence: 99%

Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies

Cui

Lin

et al. 2021

J Nanobiotechnol

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Breast cancer is the most common malignancy in women, and its incidence increases annually. Traditional therapies have several side effects, leading to the urgent need to explore new smart drug-delivery systems and find new therapeutic strategies. Graphene-based nanomaterials (GBNs) are potential drug carriers due to their target selectivity, easy functionalization, chemosensitization and high drug-loading capacity. Previous studies have revealed that GBNs play an important role in fighting breast cancer. Here, we have summarized the superior properties of GBNs and modifications to shape GBNs for improved function. Then, we focus on the applications of GBNs in breast cancer treatment, including drug delivery, gene therapy, phototherapy, and magnetothermal therapy (MTT), and as a platform to combine multiple therapies. Their advantages in enhancing therapeutic effects, reducing the toxicity of chemotherapeutic drugs, overcoming multidrug resistance (MDR) and inhibiting tumor metastasis are highlighted. This review aims to help evaluate GBNs as therapeutic strategies and provide additional novel ideas for their application in breast cancer therapy.

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“… 23 − 26 At the same time, accurate diagnosis and therapy of breast cancer is currently an important developmental direction in clinical research. 27 Therefore, the construction of a nanodrug delivery/fluorescence system to achieve the integration of tumor-targeting imaging diagnosis and treatment has become a research boom.…”

Section: Introductionmentioning

confidence: 99%

ICG-Loaded PEG-Modified Black Phosphorus Nanosheets for Fluorescence Imaging-Guided Breast Cancer Therapy

et al. 2021

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Indocyanine green (ICG) has been used in various surgical navigation systems and plays an important role in intraoperative imaging diagnosis. However, the poor photostability and unsatisfactory tumor-targeting ability have limited its broad application prospects. In the decades, the construction of a nanodrug delivery system for tumor-targeting diagnosis and therapy has become a research hotspot. Black phosphorus nanosheets (BPNS), as a new kind of biodegradable nanomaterials, have the advantages of high loading capacity, good biocompatibility, tumor targeting, and photothermal effect over other two-dimensional (2D) reported nanomaterials. Herein, ICG-loaded poly(ethylene glycol) (PEG)-modified BPNS (ICG@BPNS-PEG) nanocomposites are constructed to improve the tumor-targeting capacity and guide photothermal therapy through real-time fluorescence imaging. In this study, ICG@BPNS-PEG nanocomposites with a suitable size (240 ± 28 nm) have been successfully constructed. The photostability of ICG@BPNS-PEG nanocomposites surpassed that of free ICG after four on–off cycles of near laser irradiation (NIR). Moreover, ICG@BPNS-PEG nanocomposites have enhanced photothermal conversion ability. The cellular uptake result through flow cytometry showed that ICG@BPNS-PEG nanocomposites could be swallowed easily owing to the suitable size and passive cellular uptake. In addition, the cytotoxicity evaluation of MCF-7, 4T1 breast cancer cells, and healthy RPE cells through the MTT assay demonstrated that ICG@BPNS-PEG nanocomposites have lower cytotoxicity and good cellular compatibility without irradiation. However, the cytotoxicity and live/dead staining proved that ICG@BPNS-PEG nanocomposites have satisfactory photothermal therapeutic effects when irradiated. In the 4T1-bearing mice model, the fluorescence imaging after intravenous injection of nanocomposites showed that ICG@BPNS-PEG nanocomposites have superior passive tumor targeting accumulation through the enhanced permeability and retention (EPR) effect compared with that of free ICG. Also, changes in tumor volume showed a remarkable tumor growth inhibition effect compared with other groups. Moreover, the results of hematoxylin–eosin (H&E) staining of major organs in 4T1-bearing mice also demonstrated that the nanocomposites have good biocompatibility. Therefore, the constructed ICG@BPNS-PEG nanocomposites have substantial potential in breast cancer therapy.

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Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition

Cited by 53 publications

References 42 publications

Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells

Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells

Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies

ICG-Loaded PEG-Modified Black Phosphorus Nanosheets for Fluorescence Imaging-Guided Breast Cancer Therapy

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