Sequential treatment of giant basal cell carcinomas

Madan, Vishal; West, Chris A.; Murphy, James D.; Lear, John T.

doi:10.1016/j.bjps.2007.12.076

Cited by 22 publications

(15 citation statements)

References 20 publications

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“…Similarly, Madan et al ., recently reported that none of the “giant” BCCs had complete response to PDT and all of them ultimately required excision. [14] Furthermore, in our study, all lesions with partial response showed > 80% reduction in size at the end of treatment course. Therefore, a better response and even complete resolution could be expected in these lesions after continuing the treatment and having more PDT sessions.…”

Section: Discussionsupporting

confidence: 55%

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Aminolevulinic acid-photodynamic therapy of basal cell carcinoma and factors affecting the response to treatment: A clinical trial

et al. 2013

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Background:Basal cell carcinoma (BCC) is the most common type of skin cancer in humans. Photodynamic therapy (PDT) is a non-invasive therapeutic modality that may be considered as a valuable treatment option for BCC. This study was designed with the aim of evaluating the efficacy of PDT in treatment of BCC and factors that may affect the response rate.Materials and Methods:This clinical trial was conducted on 12 patients (28 BCC lesions) who were treated with aminulevulinic acid (ALA)-PDT, monthly, up to 6 sessions and the clinical response, cosmetic results, and possible side effects were evaluated.Results:The study was performed on 28 BCC lesions from 12 patients. Complete response was achieved in 9 (32.1%) lesions. Complete response rate was higher in younger patients (P < 0.01) and those with smaller lesions (P < 0.001). Superficial type also had significant higher response rate (P < 0.05). Patients with history of radiotherapy for the treatment of tinea capitis in childhood showed less response (P < 0.05). Cosmetic results were excellent or good in 77.5% cases. After 6 months of follow-up, none of the resolved lesions recurred.Conclusion:PDT would be a good therapeutic option in treatment of BCC with acceptable efficacy and low side effects. Younger patients, superficial BCCs, and smaller lesions show better response to ALA-PDT. History of radiotherapy may be associated with a lower response rate.

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Section: Discussionsupporting

confidence: 55%

“…This result is comparable with that of Madan et al ., who reported that none of giant BCCs showed complete response to PDT. [14] However, Rhodes et al ., did not find any significant relation between the size of the lesion and response rate. [2]…”

Section: Discussionmentioning

confidence: 99%

Aminolevulinic acid-photodynamic therapy of basal cell carcinoma and factors affecting the response to treatment: A clinical trial

et al. 2013

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“…A pilot study of 34 patients supplemented Levulan ALA‐PDT with topical imiquimod cream (twice weekly for 5 weeks after PDT) for recurrent BCC observed higher clearance rate of 75% with the combination compared with 60% by PDT alone . Combining imiquimod with MAL‐PDT for BCC may achieve improved response, but requires further study beyond current case series …”

Section: Basal Cell Carcinomamentioning

confidence: 90%

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Morton¹,

Szeimies

Basset-Séguin

et al. 2019

Acad Dermatol Venereol

138

146

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Topical photodynamic therapy (PDT) is a widely approved therapy for actinic keratoses, Bowen's disease (squamous cell carcinoma in situ), superficial and certain thin basal cell carcinomas. Recurrence rates when standard treatment protocols are used are typically equivalent to existing therapies, although inferior to surgery for nodular basal cell carcinoma. PDT can be used both as lesional and field therapies and has the potential to delay/reduce the development of new lesions. A protocol using daylight to treat actinic keratoses is widely practised, with conventional PDT using a red light after typically a 3‐h period of occlusion employed for other superficial skin cancer indications as well as for actinic keratoses when daylight therapy is not feasible. PDT is a well‐tolerated therapy although discomfort associated with conventional protocol may require pain‐reduction measures. PDT using daylight is associated with no or minimal pain and preferred by patient. There is an emerging literature on enhancing conventional PDT protocols or combined PDT with another treatment to increase response rates. This guideline, published over two parts, considers all current approved and emerging indications for the use of topical PDT in dermatology, prepared by the PDT subgroup of the European Dermatology Forum guidelines committee. It presents consensual expert recommendations reflecting current published evidence.

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“…Outcomes included free soft tissue margins and relief of pain and hygiene issues associated with the wounds [4]. In another series of cases, patients with GBCC were treated with 3 cycles of metvix photodynamic therapy and a subsequent 6-week course of topical imiquimod to decrease the size of the wound prior to excision [5]. …”

Section: Introductionmentioning

confidence: 99%

Giant Anterior Chest Wall Basal Cell Carcinoma: An Approach to Palliative Reconstruction

Santos

Prendergast

Leis

2016

Case Reports in Oncological Medicine

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Anterior chest wall giant basal cell carcinoma (GBCC) is a rare skin malignancy that requires a multidisciplinary treatment approach. This case report demonstrates the challenges of anterior chest wall GBCC reconstruction for the purpose of palliative therapy in a 72-year-old female. Surgical resection of the lesion included the manubrium and upper four ribs. The defect was closed with bilateral pectoral advancement flaps, FlexHD, and pedicled VRAM. The palliative nature of this case made hybrid reconstruction more appropriate than rigid sternal reconstruction. In advanced metastatic cancers, the ultimate goals should be to avoid risk for infection and provide adequate coverage for the defect.

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Sequential treatment of giant basal cell carcinomas

Cited by 22 publications

References 20 publications

Aminolevulinic acid-photodynamic therapy of basal cell carcinoma and factors affecting the response to treatment: A clinical trial

Aminolevulinic acid-photodynamic therapy of basal cell carcinoma and factors affecting the response to treatment: A clinical trial

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Giant Anterior Chest Wall Basal Cell Carcinoma: An Approach to Palliative Reconstruction

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