Sequential Transformations in Organic Chemistry: A Synthetic Strategy with a Future

Abstract

Organic‐chemical synthesis has always fascinated chemists and will not lose its importance in the future. It is a truism that all chemists—and others too—are dependent on the synthesis of those compounds with which they want to work. As a result, organic‐chemical synthesis today is more than ever before the cutting edge of organic chemistry, biology, biochemistry, medicine, physics, and material science. Synthesis is also the basis of the chemical industry. For the passionate synthetic chemist, however, synthesis is much more than just a method for obtaining compounds; it is the expression of his creativity, intelligence, ability, and also his perseverance.

Multi-Bond Forming Processes in Efficient Synthesis

“…Despite this similarity, all have significant differences. Tietze and Beifuss have defined 'domino' and 'consecutive' reactions [9] in order to draw a distinction between those processes that involve either a single or multiple synthetic operations. [10] Thus, a domino reaction has been defined as 'a transformation of two or more bond-forming reactions under identical reaction conditions, in which the latter transformations take place at the functionalities obtained in the former bond forming reactions'.…”

Synthesis and Biological Evaluation of some Novel Pyrano[2,3-<i>d</i>]Pyrimidine Derivatives

“…L. F. Tietze introduced the domino-Knoevenagelhetero-Diels-Alder reaction as a powerful sequential transformation [1]. It has been proven that this reaction is a valuable method for the construction of annulated pyrans [2] and has already been used for the synthesis of several natural products [3]. A family of xanthone natural products with potent antiviral activity has been isolated from plants, and it is a potent inhibitor of human immunodeficiency virus-1 reverse transcriptase [4].…”

Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles

“…A particular advantage of OPEN ACCESS these concepts is the huge increase in structural complexity facilitated by the use of even the simplest starting materials. This is also one of the driving factors for constant research advancements in this field [5][6][7][8][9][10][11][12][13][14][15][16][17].…”

“…In general, transition metal catalyzed cascade reactions can be categorized into two groups, either being domino reactions that constantly repeat the same elementary step [15][16][17], or they are constituted by reaction steps that consist of fundamentally different elementary transformations [18][19][20][21][22][23][24][25]. As such, transition metal catalyzed domino reactions involve organometallic intermediates which are constantly regenerated and yield complex, often polycyclic, organic products after numerous insertion steps and after a concluding elimination.…”