Sequential-targeting nanocarriers with pH-controlled charge reversal for enhanced mitochondria-located photodynamic-immunotherapy of cancer

Peng, Na; Yu, Hui; Yu, Wenjie; Yang, Mian; Chen, Hongxiang; Zou, Tao; Deng, Kai; Huang, Shi‐Wen; Liu, Yi

doi:10.1016/j.actbio.2020.01.005

Cited by 55 publications

(34 citation statements)

References 36 publications

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“…It impeded their growth, demonstrating a robust abscopal effect encouraging metastasis inhibition. Similarly, pH-responsive charge reversing NPs featuring enhanced tumor targetability and mitochondrial accumulation for PD-immunotherapy were reported recently (Peng et al, 2020). Sequential-targeting positively charged micelles with a Ce6 loaded core were prepared from amphiphilic poly (beta-amino ester), composed of hydrophilic CTTP-PEG and hydrophobic thioketal polymer blocks.…”

Section: Ph-responsive Charge Convertible Npsmentioning

confidence: 93%

Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

Kumar

Park

2020

Front. Bioeng. Biotechnol.

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Polymeric nanobiosensors (PNBS) that respond to tumor-related factors, including pH, have shown great potential for disease detection owing to their selectivity and sensitivity. PNBS can be converted into theranostic polymeric nanobiosensors (TPNBS) by incorporating therapeutic cargo, thereby enabling concomitant diagnoses and therapy of targeted diseases. The polymeric compartments in TPNBS play a significant role in the development and therapeutic efficacy of nanobiosensors. Polymers enhance the stability, biocompatibility, and selective or effective accumulation of nanobiosensors at desired pathological sites. The intrinsic pH sensitivity of either the polymers in TPNBS or the TPNBS themselves provides integrated potentialities such as cogent accumulation of TPNBS at the tumor, augmented tumor penetration, cellular uptake, and theranostic activation, including enhanced bioimaging signals and controlled release of therapeutics. In this review, we summarize recent developments in the design, preparation, and characterization of pH-responsive TPNBS and their ability to behave as efficient in vivo nanotheranostic agents in acidic cancer environments.

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Section: Ph-responsive Charge Convertible Npsmentioning

confidence: 93%

Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

Kumar

Park

2020

Front. Bioeng. Biotechnol.

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“…Although nanoparticles provide a platform for the in vivo applications of mitochondria-targeting PDT, their poor cancer cell membrane-targeting ability is not good for further mitochondrial targeting only (subcellular targeting) by tumor cells. Peng et al (2020) developed a sequential-targeting (tumor cell membrane and mitochondrial targeting) delivery system (named C6-loaded BioPEGDMA@TPPM) on the basis of the core-shell structure. Among them, mitochondria-targeting, chlorin e6-loaded cationic amphiphilic copolymer (C6-loaded TPPM) served as the core, and tumor cell membrane-targeting, pH-sensitive charge reversal layer based on the 2,3-dimethylmaleic anhydride (DMA)-decorated Biotin-PEG 4000 -NH 2 (BioPEGDMA) served as the shell.…”

Section: Mitochondria Targeting With the Aid Of Multifunctional Nanosystemsmentioning

confidence: 99%

Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy

Zhou

Shen

et al. 2021

Front. Bioeng. Biotechnol.

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Mitochondria, a kind of subcellular organelle, play crucial roles in cancer cells as an energy source and as a generator of reactive substrates, which concern the generation, proliferation, drug resistance, and other functions of cancer. Therefore, precise delivery of anticancer agents to mitochondria can be a novel strategy for enhanced cancer treatment. Mitochondria have a four-layer structure with a high negative potential, which thereby prevents many molecules from reaching the mitochondria. Luckily, the advances in nanosystems have provided enormous hope to overcome this challenge. These nanosystems include liposomes, nanoparticles, and nanomicelles. Here, we summarize the very latest developments in mitochondria-targeting nanomedicines in cancer treatment as well as focus on designing multifunctional mitochondria-targeting nanosystems based on the latest nanotechnology.

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“…Similarly, Liu et al. [ 165 ] fabricated a pH‐responsive and TPP‐conjugated polymeric nanoparticle for tumor tissue and cancer cellular mitochondria sequential‐targeting photosensitizer delivery, and demonstrated enhanced PDT‐induced tumor immunotherapy.…”

Section: Strategies To Enhance Spn‐elicited Cancer Immunotherapeutic mentioning

confidence: 99%

Sono/Photodynamic Nanomedicine‐Elicited Cancer Immunotherapy

Xie

et al. 2020

Adv Funct Materials

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Immunotherapy (e.g., cancer vaccines and checkpoint blockades), harnessing the host immune system to recognize and eradicate tumors, has emerged as one of the most potent cancer therapies. The clinical applications of cancer immunotherapies, however, have been limited by their low response rates and immune‐related adverse effects. In recent years, sono/photodynamic nanomedicines (SPNs) have received increasing attention for cancer therapy since they have been reported to mediate enhanced immunotherapy by generating reactive oxygen species under site‐specific exposure to exogenous energy sources. In particular, SPNs are capable of eliciting immunogenic cancer cell death, leading to the release of tumor‐associated antigens and damage‐associated molecular patterns. This allows for the maturation of antigen‐presenting cells, thus eliminating disseminated or metastatic tumor cells by cytotoxic CD8+ T cells. Such immunostimulatory features of SPNs provide opportunities to enhance therapeutic potential by amplifying anticancer immunity when combined with conventional immunotherapeutics, including immune checkpoint inhibitors. This review elaborates on the recent strategies and efforts undertaken by researchers to enhance SPN‐elicited cancer immunotherapy. The challenging issues and opportunities for SPNs in the activation of innate or adaptive immune responses and regulation of the tumor immunosuppressive microenvironment are also described.

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Sequential-targeting nanocarriers with pH-controlled charge reversal for enhanced mitochondria-located photodynamic-immunotherapy of cancer

Cited by 55 publications

References 36 publications

Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy

Sono/Photodynamic Nanomedicine‐Elicited Cancer Immunotherapy

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