Sequential Study of Bacterial Antibody Levels Antibody Levels and Faecal Flora in Rheumatoid Arthritis Patients Taking Sulphasalazine

Bradley, S. M.; Neumann, Vera; Barr, Katie; Troughton, P. R.; Astbury, Carol; Bird, H. A.; Gooi, H. C.; Wright, V.

doi:10.1093/rheumatology/32.8.683

Cited by 18 publications

(8 citation statements)

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“…Additional studies using purified LPS or heat‐killed bacteria could address this limitation. Previous studies, however, demonstrated no change in fecal E. coli counts in rheumatoid arthritis patients taking SASP 35 . Furthermore, we found no inhibitory activity of SASP against the strain of E. coli we used in this study at concentrations up to 4.1 m m (data not shown).…”

Section: Discussioncontrasting

confidence: 55%

ORIGINAL ARTICLE: Can Sulfasalazine Prevent Infection‐Mediated Pre‐Term Birth in a Murine Model?

Nath

Ananth

Smulian

et al. 2010

American J Rep Immunol

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Section: Discussioncontrasting

confidence: 55%

ORIGINAL ARTICLE: Can Sulfasalazine Prevent Infection‐Mediated Pre‐Term Birth in a Murine Model?

Nath

Ananth

Smulian

et al. 2010

American J Rep Immunol

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“…Therefore, it is clearly possible that an infectious agent will be shown to play a role in the pathogenesis of RA. Recent data on evidence of organisms demonstrated by polymerase chain reaction in the joints of some RA patients (23,24), differences in the bowel flora of RA patients with and those without erosive disease (25), and the ability of one of the most commonly used and effective DMARDs, sulfasalazine, to alter bowel flora (26,27) are intriguing.…”

Section: Discussionmentioning

confidence: 99%

Treatment of early seropositive rheumatoid arthritis with minocycline: Four-year followup of a double-blind, placebo-controlled trial

O'Dell

Paulsen

Haire

et al. 1999

Arthritis & Rheumatism

105

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“…perfringens and E. coli in patients with RA than in non-rheumatic controls [13]. perfringens were significantly lower in patients with active RA who responded well to SASP than in those with active RA who showed poor response [134]. perfringens and also E. coli count parallel clinical and biochemical improvements during the treatment of RA with SASP [133].…”

Section: Sulfasalazine ( Sasp )mentioning

confidence: 91%

Rheumatoid arthritis and enteric bacteria

Aoki

1999

Japanese Journal of Rheumatology

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Factors in the etiopathogenesis of rheumatoid arthritis (RA) include the genetic background, environmental factors and perpetuation of the inflammatory process. This review focuses on enteric bacteria as initiating or perpetuating factors in the etiopathogenesis of RA. Based on the hypothesis that entrobacterial antigens that originated from intestinal flora induce rheumatoid inflammation in the joints, animal models of arthritis due to Enterobacteriaceae, studies on humoral and cellular responses to entrobacterial antigens in RA, etiology of RA involving both genetic and environmental factors, pathogenesis of rheumatoid inflammation accompanied by joint destruction, and clinical trials with basic therapeutic considerations are reviewed. The results of immunological studies on RA suggest that some patients with RA are sensitized to antigens common among Enterobacteriaceae (bacterial outer membrane proteins of 35 and 38 kDa). A bacterial outer membrane protein of 38 kDa was identified as OmpC having amino acid homology (NYGVV) with HLA-DR4. This OmpC peptide elicited peripheral blood T cell proliferative responses in patients with RA. The presentation of this enterobacterial peptide by the RA-associated DR motif to CD4 + T cells could lead to initiation of disease. We now consider that in some patients, RA may be based on autoimmunity from molecular mimicry by entrobacterial antigens of HLA-DR4.

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Sequential Study of Bacterial Antibody Levels Antibody Levels and Faecal Flora in Rheumatoid Arthritis Patients Taking Sulphasalazine

Cited by 18 publications

References 0 publications

ORIGINAL ARTICLE: Can Sulfasalazine Prevent Infection‐Mediated Pre‐Term Birth in a Murine Model?

ORIGINAL ARTICLE: Can Sulfasalazine Prevent Infection‐Mediated Pre‐Term Birth in a Murine Model?

Treatment of early seropositive rheumatoid arthritis with minocycline: Four-year followup of a double-blind, placebo-controlled trial

Rheumatoid arthritis and enteric bacteria

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