Sequential SPECT and NIR-II imaging of tumor and sentinel lymph node metastasis for diagnosis and image-guided surgery

Zhang, Xiaolu; Zhao, Meng; Wen, Ling; Wu, Manran; Yang, Yi; Zhang, Yujuan; Wu, Yan; Zhong, Jiaming; Shi, Haibin; Zeng, Jianfeng; Wang, Guanglin; Gao, Mingyuan

doi:10.1039/d1bm00088h

Cited by 14 publications

(11 citation statements)

References 48 publications

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“…Depending on the time and aims of using imaging technologies in surgery, medical imaging includes preoperative, intraoperative and postoperative imaging and detection [19].…”

Section: Methods Of Sln Detectionmentioning

confidence: 99%

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Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Kurochkin

German

Abalymov

et al. 2021

Journal of Biophotonics

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The status of sentinel lymph nodes (SLNs) has a substantial prognostic value because these nodes are the first place where cancer cells accumulate along their spreading route. Routine SLN biopsy ("gold standard") involves peritumoral injections of radiopharmaceuticals, such as technetium-99m, which has obvious disadvantages. This review examines the methods used as "gold standard" analogs to diagnose SLNs. Nonradioactive preoperative and intraoperative methods of SLN detection are analyzed. Promising photonic tools for SLNs detection are reviewed, including NIR-I/NIR-II fluorescence imaging, photoswitching dyes for SLN detection, in vivo photoacoustic detection, imaging and biopsy of SLNs. Also are discussed methods of SLN detection by magnetic resonance imaging, ultrasonic imaging systems including as combined with photoacoustic imaging, and methods based on the magnetometer-aided detection of superparamagnetic nanoparticles. The advantages and disadvantages of nonradioactive SLN-detection methods are shown. The review concludes with prospects for the use of conservative diagnostic methods in combination with photonic tools.

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“…Depending on the time and aims of using imaging technologies in surgery, medical imaging includes preoperative, intraoperative and postoperative imaging and detection [19].…”

Section: Methods Of Sln Detectionmentioning

confidence: 99%

“…For preoperative imaging, noninvasive and deep-tissue penetration is required, whereas high spatiotemporal resolution is more important for intraoperative imaging. Each imaging step involves the use of different agents [19,20].…”

Section: Preoperative Methodsmentioning

confidence: 99%

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Kurochkin

German

Abalymov

et al. 2021

Journal of Biophotonics

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“…Recently, by encapsulating a radiolabeled hydrophobic NIR‐II cyanine fluorophore ( 125 I‐MT) into a copolymer, Gao and colleagues developed a multifunctional NIR‐II nanoprobe. Based on the single‐photon emission computed tomography (SPECT) and NIR‐II fluorescence dual‐mode imaging technique, clear images of subcutaneous tumors and lymph node metastases could be sensitively and precisely obtained with the injection of nanoprobe in the mouse model [43] …”

Section: Cyanine Fluorophores For Nir‐ii Imaging and Nir‐ii Sensingmentioning

confidence: 99%

“…Based on the single-photon emission computed tomography (SPECT) and NIR-II fluorescence dual-mode imaging technique, clear images of subcutaneous tumors and lymph node metastases could be sensitively and precisely obtained with the injection of nanoprobe in the mouse model. [43] At present, the treatment of solid tumors is mainly based on surgical resection. [44] The main goal of tumor resection surgery is to completely remove the primary tumor and metastases while minimizing damage to normal tissues.…”

Section: Development Of Asymmetric Nir-ii Cyanine Fluorophoresmentioning

confidence: 99%

Recent Progress of Cyanine Fluorophores for NIR‐II Sensing and Imaging

Zhou

Ren

2022

Chemistry An Asian Journal

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The cyanine fluorophores, a kind of classic organic fluorophores, are famous for their high extinction coefficient, simple synthetic route, and relatively long absorption and emission wavelengths. Moreover, the excellent biocompatibility and low toxicity in biological samples make cyanine fluorophores show excellent application value in the biomedical field, especially in Near-Infrared II (NIR-II) sensing and imaging. In this review, we briefly outline the history, characteristics, and current state of development of cyanine fluorophores. In particular, we described the application of cyanine fluorophores in NIR-II sensing and imaging. We hope this review can help researchers grab the latest information in the fast-growing field of cyanine fluorophores for NIR-II sensing and imaging.

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“…At present, it has been widely used in many countries in Asia, Europe and North America. The development trend of SPECT/CT in the future involves the exploration of non‐radioactive tracers, molecular targeted labeling tracers, 10 and mixed tracers 15 …”

Section: Isotopic Tracer Methodsmentioning

confidence: 99%

Advanced diagnostic imaging of sentinel lymph node in early stage breast cancer

Sun

2022

J of Clinical Ultrasound

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Sentinel lymph node biopsy has been regarded as the standard procedure for early staging breast cancer. One of the key steps is to locate the sentinel lymph node (SLN). The recommended method is the joint use of blue dye and radioisotope. However, due to radionuclide radiation and high cost, it is urgent to develop more convenient and sensitive imaging methods to accurately locate SLN. This article discusses the advancement of accurately locating SLN by isotope tracer imaging, magnetic tracer method, computed tomographic lymphography, and trans‐lymphatic contrast‐enhanced ultrasound, as well as proposing new propose for clinical diagnosis.

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Sequential SPECT and NIR-II imaging of tumor and sentinel lymph node metastasis for diagnosis and image-guided surgery

Abstract: Efficacious cancer treatment largely relies on accurate imaging diagnosis and imaging-guided surgery, which can be achieved by combining different mode imaging probes on one single nanoplatform. Herein, a novel radiolabeled...

Cited by 14 publications

References 48 publications

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Recent Progress of Cyanine Fluorophores for NIR‐II Sensing and Imaging

Advanced diagnostic imaging of sentinel lymph node in early stage breast cancer

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