Sequential radiation and operation in carcinoma of the uterine cervix

Decker, David G.; Aaro, Leonard A.; Hunt, Arthur B.; Johnson, Carl E.; Smith, Reginald A.

doi:10.1016/0002-9378(65)90102-x

Cited by 17 publications

(2 citation statements)

References 7 publications

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“…(8) According to Decker et al, (7) the presence of residual tumor after radiotherapy, associated with the presence of positive lymph nodes, was a fatal event even though the group was small. (7) The correlation of clinical stage with a greater possibility of residual tumor persistence was studied by Parker et al (20) Among their patients, those in stage I presented metastatic lymph node disease in 8% of cases, whereas those in stage II presented metastatic lymph node disease in 28% of cases. Among the patients submitted to complete preoperative radiotherapy (external radiotherapy and brachytherapy), the incidence of residual disease was 25% and the persistence of positive lymph nodes was 16%.…”

Section: Pathology Of the Surgical Specimenmentioning

confidence: 99%

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Preoperative irradiation therapy and radical hysterectomy: prognostic value of tumor regression after initial irradiation of squamous cell carcinoma of the cervix

Coelho

Franco

Kowalski³

et al. 1998

Sao Paulo Med. J.

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OBJECTIVE: To investigate the role of tumor persistence in patients submitted to irradiation therapy and radical hysterectomy. DESIGN: A retrospective analysis of prognostic factors. LOCATION: Hospital A.C. Camargo, São Paulo, Brazil, a private non-profitmaking foundation and tertiary referral centre. PATIENTS: A total of 629 cases of invasive squamous cell carcinoma of the cervix were studied. Criteria for inclusion in the study were: confirmed histological diagnosis of squamous cell carcinoma and no previous treatment (except for preoperative radiotherapy carried out at the Hospital A.C. Camargo itself). At the end of the follow-up period, 410 patients (65%) had no evidence of disease and 219 (34.8%) had died because of the tumor. INTERVENTION: The patients were submitted to radical surgery and radiation therapy, separately or in combination between 1953 and 1982. MAIN OUTCOMES MEASURES: Multivariate analysis of the different variables was performed according to the Cox regression method. RESULTS: The variables of prognostic value were, in decreasing order of importance: the decade of patient admission (p = 0.0001), the modality of therapy employed (p = 0.0005), the presence of residual tumor in the surgical specimens (p = 0.0055) and the clinical stage of the disease (p = 0.0575). CONCLUSIONS: Radiation therapy controlled a considerable number of local tumors and pelvic lymph nodes but not all of them in every patient. There is a specific group of patients for whom radical surgery is necessary to achieve control of the disease.

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Section: Pathology Of the Surgical Specimenmentioning

confidence: 99%

“…(6) Tumor persistence I 1701 after initial brachytherapy has been considered to be an unfavorable prognostic factor. (7,8) The present investigation was undertaken in order to investigate the role of irradiation therapy and radical hysterectomy performed over three decades at the same Institution.…”

Section: Introductionmentioning

confidence: 99%

Preoperative irradiation therapy and radical hysterectomy: prognostic value of tumor regression after initial irradiation of squamous cell carcinoma of the cervix

Coelho

Franco

Kowalski³

et al. 1998

Sao Paulo Med. J.

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Radiosensitivity studies in treatment of cancer of the cervix

Merrill

1966

Cancer

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One hundred‐ninety‐two patients with cancer of the cervix treated by primary radiation therapy during the years 1957 thru 1960 were studied by SR, serial RR and serial cervical biopsies. It has been impossible to demonstrate any value of SR as a prognostic index. Patients with “good” RR have a higher survival rate than patients with “poor” RR but the differences are not statistically significant. RR is influenced by numerous factors. The prognostic accuracy of examining cervical biopsies is greater than with the cytologic techniques and differences in survival rate are statistically significant. It is concluded that radiosensitivity testing techniques offer little advantage in the clinical management of patients with cancer of the cervix.

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Major surgery after radical radiotherapy.Indications and complications

Rafla¹

1971

Cancer

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The study of one hundred and forty‐two patients who underwent major surgery after a radical course of radiotherapy for pelvic and head and neck tumors has revealed the following trends: The most important complications in the immediate postoperative period are the problem of healing for tumors of the head and neck (26%) and death (within 30 days) for pelvic tumors (10%). Late results are rather disappointing in tumors in both sites. Forty‐three percent of patients with head and neck tumors suffered from local recurrence, and an additional 11% suffered from severe pain and died. Fifteen per cent of the pelvic tumors recurred; another 9% of patients continued to have residual disease, and 15 experienced severe pain and ultimately died. Only one quarter of the patients were alive and well after 5 years. Patients who undergo surgery because of complications of radiotherapy seem to do significantly better than those with recurrent or residual disease. The latter group has the worse results, whether in the immediate postoperative period or long term. The more limited the operation is, the better the chance of uncomplicated postoperative course and long‐term survival. Younger patients have less postoperative complications and higher 5‐year survival, especially those with cancer of cervix.

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Sequential radiation and operation in carcinoma of the uterine cervix

Cited by 17 publications

References 7 publications

Preoperative irradiation therapy and radical hysterectomy: prognostic value of tumor regression after initial irradiation of squamous cell carcinoma of the cervix

Preoperative irradiation therapy and radical hysterectomy: prognostic value of tumor regression after initial irradiation of squamous cell carcinoma of the cervix

Radiosensitivity studies in treatment of cancer of the cervix

Major surgery after radical radiotherapy.Indications and complications

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