2019
DOI: 10.1214/18-aos1737
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Sequential multiple testing with generalized error control: An asymptotic optimality theory

Abstract: The sequential multiple testing problem is considered under two generalized error metrics. Under the first one, the probability of at least k mistakes, of any kind, is controlled. Under the second, the probabilities of at least k1 false positives and at least k2 false negatives are simultaneously controlled. For each formulation, the optimal expected sample size is characterized, to a first-order asymptotic approximation as the error probabilities go to 0, and a novel multiple testing procedure is proposed and… Show more

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Cited by 30 publications
(27 citation statements)
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References 43 publications
(145 reference statements)
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“…By a similar argument as we developed when proving (25), the RHS of (35) decreases exponentially with n. Hence, (22) follows.…”
Section: A Proof Of Theoremsupporting
confidence: 53%
See 1 more Smart Citation
“…By a similar argument as we developed when proving (25), the RHS of (35) decreases exponentially with n. Hence, (22) follows.…”
Section: A Proof Of Theoremsupporting
confidence: 53%
“…In this paper, we focus on asymptotically optimal strategies with low computational complexity for sequential search of a target over multiple processes. Different models considered the case of searching for targets without constraints on the probing capacity, whereas all processes are probed at each given time (i.e., K = M, which is a special case of the setting considered in this paper) [17], [22], [23], [35].…”
Section: B Related Workmentioning
confidence: 99%
“…We assume that the prior distribution for the change points, and the pre-and post-change distributions are known, which is a standard assumption in single-stream Bayesian sequential change detection (e.g., Shiryaev, 1963). Similar assumptions are adopted in recent developments on multi-stream sequential multiple testing (Song and Fellouris, 2019) and Statistica Sinica: Newly accepted Paper (accepted author-version subject to English editing) 2.1 Bayesian Change-point Model for Parallel Streams multi-stream sequential change detection (Chen, Zhang and Poor, 2020).…”
Section: Bayesian Change-point Model For Parallel Streamsmentioning
confidence: 99%
“…Different from our goal in developing dynamic statistical inference, their settings are completely from ours because they aim to minimize the overall expectation delay while controlling the average run length under the null hypothesis that none of the datastreams experience changes. Recent works on sequential testing based on the sequential probability ratio test (SPRT) rules such as Bartroff (2018) and Song and Fellouris (2019) are computationally intensive, making it infeasible for large-scale studies such as those arising from IHS where millions of tests are conducted simultaneously at each time.…”
Section: Connections To Existing Workmentioning
confidence: 99%