Sequential MR imaging (with diffusion-weighted imaging) changes in metronidazole-induced encephalopathy

Singh, Rupinder; Kaur, Ramanjeet; Pokhariyal, Pawan; Aggarwal, Rajul

doi:10.4103/ijri.ijri_341_16

Cited by 10 publications

(7 citation statements)

References 8 publications

(12 reference statements)

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“…Metronidazole may increase the risk of selection of multidrug resistant E coli 50 51 and possibly favours bacterial translocation 52. Finally, metronidazole can cause a potentially severe neurotoxicity in dogs,53–55 as well in humans56–59 and should therefore be used cautiously.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016

Lutz

Lehner

Schmitt

et al. 2020

Veterinary Record Open

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BackgroundAntimicrobial resistance is an increasing problem in human and veterinary medicine and is closely linked to the use of antimicrobials. The objective of this study was to describe antimicrobial prescriptions for selected canine diseases in Switzerland during 2016.MethodsDogs presented to two university hospitals and 14 private practices for acute diarrhoea (AD; n=371), suspected or confirmed urinary tract infections (UTIs; n=245), respiratory tract infections (RTIs; n=274) or wound infections (WIs; n=175) were included. Clinical history, diagnostic work-up and antimicrobial prescription (class, dosage and duration) were retrospectively assessed. A justification score was applied to evaluate appropriateness of antimicrobial therapy based on available national and international consensus guidelines.ResultsAntimicrobials were prescribed in 65 per cent of dogs with AD, 88 per cent with UTI, 62 per cent with RTI and 90 per cent with WI. The most prescribed antimicrobial classes (monotherapy and combination therapy) were potentiated aminopenicillins (59 per cent), nitroimidazoles (22 per cent), non-potentiated aminopenicillins (16 per cent) and fluoroquinolones (13 per cent). Overall, 38 per cent (95 per cent CI 0.35 to 0.41) of the prescriptions were in accordance with consensus guidelines. In dogs with AD, antimicrobial therapy was associated with the presence of haemorrhagic diarrhoea (P<0.05) and complied in 32 per cent with consensus guidelines, which recommend antimicrobial treatment only when sepsis is suspected. A bacterial aetiology was confirmed via culture and/or sediment examination in 36 per cent of dogs with suspected UTI.ConclusionsOverall, adherence to consensus guidelines was poor both, at university hospitals and private practices. Antimicrobial stewardship measures are therefore needed to improve prudent use.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016

Lutz

Lehner

Schmitt

et al. 2020

Veterinary Record Open

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“…In some cases, lesions of the dentate nuclei were not present initially but revealed on re‐imaging. 7 , 8 The majority of the cases present cerebellar dysfunction (dysarthria, ataxia, dysmetria, and nystagmus) followed by altered mental status and seizures, 5 chorea, myoclonus, 9 , 10 and pure sensorineural hearing loss are also reported. 11 The patient has also taking methadone, and there are reports of toxic leukoencephalopathy due to methadone.…”

Section: Discussionmentioning

confidence: 99%

A case report of toxic leukoencephalopathy induced by metronidazole in a woman with surgical site infection

Dana¹,

Arani²,

Faraji

et al. 2021

Clinical Case Reports

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“…T2/FLAIR hyperintense lesions in the dentate nuclei, are the best diagnostic finding. In some cases, lesions of the dentate nuclei were not present initially but revealed on re-imaging 7,8 . The majority of the cases present cerebellar dysfunction (dysarthria, ataxia, dysmetria, and nystagmus) followed by altered mental status and seizures 5 , Chorea, myoclonus 9,10 and pure sensorineural hearing loss are also reported 11 .…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Toxic Leukoencephalopathy induced by metronidazole in a woman with suture infection

Dana

Arani

Faraji

et al. 2021

Preprint

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Sequential MR imaging (with diffusion-weighted imaging) changes in metronidazole-induced encephalopathy

Cited by 10 publications

References 8 publications

Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016

Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016

A case report of toxic leukoencephalopathy induced by metronidazole in a woman with surgical site infection

A Case Report of Toxic Leukoencephalopathy induced by metronidazole in a woman with suture infection

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