Sequential Magnetic Resonance Imaging Reveals Individual Level Deformities of Vertebrae and Discs in the Growing Scoliotic Spine

Keenan, Bethany E.; Izatt, Maree T.; Askin, Geoffrey N.; Labrom, Robert D.; Bennett, Damon Dmitry; Pearcy, Mark J.; Adam, Clayton J.

doi:10.1016/j.jspd.2016.10.002

Cited by 11 publications

(14 citation statements)

References 16 publications

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“…MRI scanning protocol, acquisition methods, and image reformatting to obtain segmental deformity parameters in each of the three dimensions were done in accordance with the methods described in previous works. [14][15][16]20 MRI planar images with overlayed border demarcations, with examples of changes seen at the first and last scans, are shown in Figure 1.…”

Section: Mri Protocolmentioning

confidence: 99%

“…34 Nonetheless, MRI is becoming a popular imaging modality that has measured wedging in previous scoliotic deformity investigations, with these supine findings also correlating strongly to upright measurements. [14][15][16]20,35 Finally, most AIS participants were braced with spinal orthoses throughout the observation period, although with varying levels of compliance. Braces were removed a minimum of two hours before scanning.…”

Section: Deformitymentioning

confidence: 99%

“…7 Previously, the majority of AIS segmental research typically addressed only one of these two factors: characterizing 3D deformity at a single timepoint, 2,3,8 or characterizing monoplanar or biplanar deformity at multiple timepoints. [14][15][16] For example, in previous sequential magnetic resonance imaging (MRI) deformity studies, 14,15 only the coronal plane wedging angles of VBs and IVDs were measured. Thereby, for what is considered a potentially progressively deforming condition, few investigations have sequentially imaged AIS patients in three dimensions.…”

mentioning

confidence: 99%

“…E, (rib hump = 14°) and F, (rib hump = 18°) showthe reformatted axial plane cuts at the apical level (T9 superior end plate) with overlaid demarcation of endplate surface area. These demarcations are utilized to measure wedging angles and values of rotation via their respective methods outlined in previous works [14][15][16]20.…”

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confidence: 99%

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Quantifying Typical Progression of Adolescent Idiopathic Scoliosis

Labrom,

Izatt,

Askin

et al. 2023

Spine

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Study Design. A prospective cohort study. Objective. Detail typical three-dimensional segmental deformities and their rates of change that occur within developing adolescent idiopathic scoliosis (AIS) spines over multiple timepoints. Summary of Background Data. AIS is a potentially progressive deforming condition that occurs in three dimensions of the scoliotic spine during periods of growth. However, there remains a gap for multiple timepoint segmental deformity analysis in AIS cohorts during development. Materials and Methods. Thirty-six female patients with Lenke 1 AIS curves underwent two to six sequential magnetic resonance images. Scans were reformatted to produce images in orthogonal dimensions. Wedging angles and rotatory values were measured for segmental elements within the major curve. Two-tailed, paired t tests compared morphologic differences between sequential scans. Rates of change were calculated for variables given the actual time between successive scans. Pearson correlation coefficients were determined for multidimensional deformity measurements. Results. Vertebral bodies were typically coronally convexly wedged, locally lordotic, convexly axially rotated, and demonstrated evidence of local mechanical torsion. Between the first and final scans, apical measures of coronal wedging and axial rotation were all greater in both vertebral and intervertebral disk morphology than nonapical regions (all reaching differences where P<0.05). No measures of sagittal deformity demonstrated a statistically significant change between scans. Cross-planar correlations were predominantly apparent between coronal and axial planes, with sagittal plane parameters rarely correlating across dimensions. Rates of segmental deformity changes between earlier scans were characterized by coronal plane convex wedging and convexly directed axial rotation. The major locally lordotic deformity changes that did occur in the sagittal plane were static between scans. Conclusions. This novel investigation documented a three-dimensional characterization of segmental elements of the growing AIS spine and reported these changes across multiple timepoints. Segmental elements are typically deformed from initial presentation, and subsequent changes occur in separate orthogonal planes at unique times.

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Section: Mri Protocolmentioning

confidence: 99%

Section: Deformitymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Quantifying Typical Progression of Adolescent Idiopathic Scoliosis

Labrom,

Izatt,

Askin

et al. 2023

Spine

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“…These pathological conditions of the spine are usually diagnosed through radiography (especially X-ray images) because it can quickly acquire the pathological condition and location information of the bone, has low radiation exposure, and has wide availability [ 5 , 6 ]. Recently, several methods for diagnosing spinal misalignment based on medical images, such as ultrasound, CT, and MRI, have been developed, but these are extensions of X-ray-based measurement, which is still considered the gold standard [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Reliability Analysis of Vertebral Landmark Labelling on Lumbar Spine X-ray Images

Jang

Kim

et al. 2023

Diagnostics

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Vertebral landmark labelling on X-ray images is important for objective and quantitative diagnosis. Most studies related to the reliability of labelling focus on the Cobb angle, and it is difficult to find studies describing landmark point locations. Since points are the most fundamental geometric feature that can generate lines and angles, the assessment of landmark point locations is essential. The aim of this study is to provide a reliability analysis of landmark points and vertebral endplate lines with a large number of lumbar spine X-ray images. A total of 1000 pairs of anteroposterior and lateral view lumbar spine images were prepared, and 12 manual medicine experts participated in the labelling process as raters. A standard operating procedure (SOP) was proposed by consensus of the raters based on manual medicine and provided guidelines for reducing sources of error in landmark labelling. High intraclass correlation coefficients ranging from 0.934 to 0.991 verified the reliability of the labelling process using the proposed SOP. We also presented means and standard deviations of measurement errors, which could be a valuable reference for evaluating both automated landmark detection algorithms and manual labelling by experts.

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