Sequential loading of inclusion complex/nanoparticles improves the gastric retention of Vladimiriae Radix essential oil to promote the protection of acute gastric mucosal injury

Yan, Xiaomin; Huang, Zecheng; Wu, Yuyi; Yu, Ziwei; Yang, Ke; Chen, Ziqiang; Wang, Wenjun; Hu, Huiling; Wang, Zhanguo

doi:10.1016/j.ijpharm.2021.121234

Cited by 9 publications

(3 citation statements)

References 48 publications

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“…The use of herbal medications for treating gastric ulcers has been gaining popularity. This is not only because studies involving humans and animal models have shown that their efficacy was equivalent or even better than that of drugs, such as cimetidine and omeprazole [ 12 ], but also because ulcer therapies based on herbal medicine tend to be less expensive than chemical-based ones [ 13 , 14 ]. For instance, the South Korean multiherbal formula SR-5 has been reported to considerably decrease the ulcer index in mice, with agarwood extracts producing similar effects, along with reduced inflammation, against stomach ulcers in rats [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats

Bao¹,

Li²,

Cho³

et al. 2022

Genes

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This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the mechanism behind this protective effect. Rats were pretreated with MD-4 (0.3, 1.5, or 3 g/kg per day) for 21 days before inducing gastric ulcers by oral administration with indomethacin (30 mg/kg). Unulcerated and untreated healthy rats were used as controls. Effects of the treatment were assessed based on the ulcer index, histological and pathological examinations, and indicators of inflammation, which were determined by enzyme-linked immunosorbent assay. Transcriptomic analysis was performed for identifying potential pharmacological mechanisms. Eventually, after identifying potential target genes, the latter were validated by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). After pretreatment with MD-4, gastric ulcers, along with other histopathological features, were reduced. MD-4 significantly (p < 0.05) increased the superoxide dismutase (SOD) levels in ulcers and reduced pepsin, TNF-α, and IL-6 levels. RNA-seq analysis identified a number of target genes on which MD-4 could potentially act. Many of these genes were involved in pathways that were linked to anti-inflammatory and antioxidant responses, and other protective mechanisms for the gastric mucosa. qRT-PCR showed that altered expression of the selected genes, such as Srm, Ryr-1, Eno3, Prkag3, and Eef1a2, was consistent with the transcriptome results. MD-4 exerts protective effects against IND-induced gastric ulcers by reducing inflammatory cytokines and pepsin and increasing the expression of SOD levels. Downregulation of Srm, Ryr-1, Eno3, Prkag3, and Eef1a2 genes involved in regulating arginine and proline metabolism, calcium signaling pathway, HIF-1 signaling pathway, oxytocin signaling pathway, and legionellosis are possibly involved in MD-4-mediated protection against gastric ulcers.

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Section: Introductionmentioning

confidence: 99%

RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats

Bao¹,

Li²,

Cho³

et al. 2022

Genes

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show abstract

“…These significances consistent abundant other exercises that obtainable substantial upsurge of stomach mucus concentration (PAS) stains nourished several compounds against ethanol produced gastric damages. [48][49][50] PAS stains Figure 2: Effect of the gold nanoparticle using aqueous rhizomes extract of Zingiber officinale on antioxidant enzyme activities (SOD and CAT) and MDA level in the liver. Statistically significant differences were examined using one-way ANOVA and Tukey's post hoc multiple comparisons test.…”

Section: Discussionmentioning

confidence: 99%

“…[43,52] Furthermore, reduction in MDA quantities were specified rats forced feeding with many herbal and artificial composites. [50,53] ROS, for example, hydroxyl radicals, superoxide anions, and lipid peroxides damaging programs approved to worsen gastric ulcer development. [54] Antioxidants hunt free-radical formation exhibition principal portion in the protection of cellular damage.…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Shareef

Hadi

‎

et al. 2022

Cihan U Erbil SCI J

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Synthesis of gold nanoparticles exhibition wide range of bioactivities and was conventionally used for the remedy of numerous disorders. Our study aims to measure the gastroprotective effect of synthesized gold nanoparticles on absolute ethanol-induced stomach ulceration in rats. The rats were noticeably administered with two doses of gold nanoparticles (175 ppm and 350 ppm) with absolute alcohol and showed a significant improvement in the adverse effect of ethanol-produced stomach damage as confirmed by decreasing ulcer index and raising % of ulcer prevention. Increased mucus pH of stomach content reduced ulcerated portion, condensed or nonappearance of edema, and white blood cells permeation subcutaneous layer. In gastric tissue homogenate, synthesized gold nanoparticles presented a substantial increase in superoxide dismutase (SOD), catalase (CAT) actions, and a substantial lessening of malondialdehyde (MDA) amount. Besides, gold nanoparticle increases the intensity of periodic acid Schiff stained (PAS) of the gastric epithelium of the stomach. Gold nanoparticles confirmed gastro-protective effects which might be qualified to its antioxidant, increase mucus secretion, increase endogenous enzymes (SOD and CAT), and reduce MDA quantity.

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Inclusion complex essential oil into cyclodextrins and its optimization via experimental designs: a review

Ez-zoubi,

Zaroual,

Zoubi

et al. 2024

Chem. Pap.

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Sequential loading of inclusion complex/nanoparticles improves the gastric retention of Vladimiriae Radix essential oil to promote the protection of acute gastric mucosal injury

Cited by 9 publications

References 48 publications

RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats

RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Inclusion complex essential oil into cyclodextrins and its optimization via experimental designs: a review

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