Sequential Involvement of Oculomotor Nerve and Optic Nerve Sheath in Relapsing Polychondritis

Ikeda, Toshihide; Yoshida, Takeshi; Yamamoto, Hirotaka; Hashida, Masatsugu; Urabe, Kimiaki; Sotozono, Chie; Fukuda, Ken

doi:10.1097/wno.0000000000001321

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…Ischemic optic neuropathy may be induced by systemic vasculitis. We have reported two cases of optic perineuritis [23,27]. One patient presented with recurrent optic perineuritis as the first manifestation of RPC [23].…”

Section: Optic Nerve and Other Cranial Nervementioning

confidence: 97%

“…One patient presented with recurrent optic perineuritis as the first manifestation of RPC [23]. Optic perineuritis (Figure 5B) occurred sequentially after oculomotor nerve palsy, scleritis, and retinitis in another case [27].…”

Section: Optic Nerve and Other Cranial Nervementioning

confidence: 98%

“…Scleritis/episcleritis is the most common ocular complication associated with RPC (Table 3) [10,[26][27][28][29][30][31][32][33][34]. Most cases of scleritis occur bilaterally.…”

Section: Scleramentioning

confidence: 99%

“…Optic neuropathy is a rare ocular complication, although it is the most common cranial nerve disorder associated with RPC. Optic neuropathy includes optic neuritis, papilledema, ischemic optic neuropathy, and optic perineuritis [10,23,27,[57][58][59][60][61]. Ischemic optic neuropathy may be induced by systemic vasculitis.…”

Section: Optic Nerve and Other Cranial Nervementioning

confidence: 99%

“…Other cranial nerve involvements reportedly include oculomotor and abducens nerve palsies, as well as trigeminal neuralgia [10,22,26,27,62,63]. Oculomotor and abducens nerve palsies result in extraocular muscle palsies and can also be the initial manifestation of RPC [22].…”

Section: Optic Nerve and Other Cranial Nervementioning

confidence: 99%

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Ocular Involvement in Relapsing Polychondritis

Fukuda

Mizobuchi

Nakajima

et al. 2021

JCM

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Relapsing polychondritis (RPC) is a rare systemic immune-mediated disease characterized by recurrent inflammation of cartilaginous and proteoglycan-rich tissues throughout the body. Auricular, nasal, tracheal, and articular chondritis and arthritis are common systemic symptoms in patients with RPC. Ocular tissues are also targets of inflammation in RPC, and a variety of ocular symptoms are observed in approximately half of the patients with RPC. Scleritis/episcleritis, uveitis, and conjunctivitis are common symptoms associated with RPC. Less frequently, keratitis, retinopathy, optic neuropathy, muscle palsy, and orbital inflammation are also observed. Ocular inflammation could also be the first manifestation of RPC. Although RPC is a potentially fatal and sight-threatening disease, the rarity of the disease and its protean clinical presentation may lead to delayed diagnosis or misdiagnosis. Given the high prevalence of ocular involvement in RPC, to avoid misdiagnosis, physicians should be suspicious of RPC when they see patients with recurrent ocular inflammatory conditions and various systemic symptoms. In this article, we provide a comprehensive review of ocular manifestations associated with RPC.

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Section: Optic Nerve and Other Cranial Nervementioning

confidence: 97%

Section: Optic Nerve and Other Cranial Nervementioning

confidence: 98%

“…Scleritis/episcleritis is the most common ocular complication associated with RPC (Table 3) [10,[26][27][28][29][30][31][32][33][34]. Most cases of scleritis occur bilaterally.…”

Section: Scleramentioning

confidence: 99%

Section: Optic Nerve and Other Cranial Nervementioning

confidence: 99%

Section: Optic Nerve and Other Cranial Nervementioning

confidence: 99%

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Ocular Involvement in Relapsing Polychondritis

Fukuda

Mizobuchi

Nakajima

et al. 2021

JCM

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The ocular manifestations of relapsing polychondritis

2023

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PurposeRelapsing polychondritis (RPC) is a rare, multi-system, in ammatory disorder. Ocular disease is estimated to occur in 14 to 67% of patients with RPC and any ocular structure can be affected. Published case reports and series of RPC were analysed to determine the frequency and nature of the ocular manifestations of RPC, including the age and gender distribution. MethodsA literature search of the MEDLINE database for case reports and series on RPC was conducted using search terms (relapsing polychondritis [MeSH Major Topic]) OR (relapsing polychondritis[Title/Abstract]).Articles were included if the diagnosis of RPC was con rmed using established diagnostic criteria and if the paper described the clinical features of patients with RPC. Results546 articles (454 case reports and 92 case series) described the clinical features in a total of 2414 patients with RPC. 49% of patients with RPC had ocular involvement and this was a presenting feature in 21%. The most common ocular manifestations were scleritis (32%), episcleritis (31%) and uveitis (23%). ConclusionMany patients with RPC will be seen by an ophthalmologist during the course of their disease. Knowledge and awareness of RPC and its ocular manifestations is therefore essential to enable the ophthalmologist to make the diagnosis.

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The Ocular Manifestations of Relapsing Polychondritis

Gallagher

Al-Janabi

Wang

2022

Preprint

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Purpose Relapsing polychondritis (RPC) is a rare, multi-system, inflammatory disorder. Ocular disease is estimated to occur in 14 to 67% of patients with RPC and any ocular structure can be affected. Published case reports and series of RPC were analysed to determine the frequency and nature of the ocular manifestations of RPC, including the age and gender distribution. Methods A literature search of the MEDLINE database for case reports and series on RPC was conducted using search terms (relapsing polychondritis[MeSH Major Topic]) OR (relapsing polychondritis[Title/Abstract]). Articles were included if the diagnosis of RPC was confirmed using established diagnostic criteria and if the paper described the clinical features of patients with RPC. Results 546 articles (454 case reports and 92 case series) described the clinical features in a total of 2414 patients with RPC. 49% of patients with RPC had ocular involvement and this was a presenting feature in 21%. The most common ocular manifestations were scleritis (32%), episcleritis (31%) and uveitis (23%). Conclusion Many patients with RPC will be seen by an ophthalmologist during the course of their disease. Knowledge and awareness of RPC and its ocular manifestations is therefore essential to enable the ophthalmologist to make the diagnosis.

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Sequential Involvement of Oculomotor Nerve and Optic Nerve Sheath in Relapsing Polychondritis

Cited by 3 publications

References 5 publications

Ocular Involvement in Relapsing Polychondritis

Ocular Involvement in Relapsing Polychondritis

The ocular manifestations of relapsing polychondritis

The Ocular Manifestations of Relapsing Polychondritis

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