Sequential intervention of anti-inflammatory and osteogenesis with silk fibroin coated polyethylene terephthalate artificial ligaments for anterior cruciate ligament reconstruction

Chen, Ni; Jin, Wenhe; Han, Gaorong; Hong, Jianming; Sun, Luyi; Yao, Jinrong; Chen, Xin; Chen, Shiyi; Shao, Zhengzhong

doi:10.1039/d3tb00911d

J. Mater. Chem. B

2023

DOI: 10.1039/d3tb00911d

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Sequential intervention of anti-inflammatory and osteogenesis with silk fibroin coated polyethylene terephthalate artificial ligaments for anterior cruciate ligament reconstruction

Ni Chen¹,

Wenhe Jin²,

Gaorong Han³

et al.

Abstract: Graft-host integration after anterior cruciate ligament (ACL) reconstruction sequentially follows the prognosis from inflammation period to regeneration period. However, due to the insufficient bioactivity, polyethylene terephthalate (PET) artificial ligaments often...

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2024

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Cited by 3 publications

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A machine learning system for artificial ligaments with desired mechanical properties in ACL reconstruction applications

Peng,

Liu,

et al. 2024

Journal of the Mechanical Behavior of Biomedical Materials

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A machine learning system for artificial ligaments with desired mechanical properties in ACL reconstruction applications

Peng,

Liu,

et al. 2024

Journal of the Mechanical Behavior of Biomedical Materials

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Silk fibroin-based scaffolds for tissue engineering

Ma,

Dong,

Lai

et al. 2024

Front. Bioeng. Biotechnol.

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Silk fibroin is an important natural fibrous protein with excellent prospects for tissue engineering applications. With profound studies in recent years, its potential in tissue repair has been developed. A growing body of literature has investigated various fabricating methods of silk fibroin and their application in tissue repair. The purpose of this paper is to trace the latest developments of SF-based scaffolds for tissue engineering. In this review, we first presented the primary and secondary structures of silk fibroin. The processing methods of SF scaffolds were then summarized. Lastly, we examined the contribution of new studies applying SF as scaffolds in tissue regeneration applications. Overall, this review showed the latest progress in the fabrication and utilization of silk fibroin-based scaffolds.

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The Application of Regenerated Silk Fibroin in Tissue Repair

Li,

Tan,

Xie

et al. 2024

Materials

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Silk fibroin (SF) extracted from silk is non-toxic and has excellent biocompatibility and biodegradability, making it an excellent biomedical material. SF-based soft materials, including porous scaffolds and hydrogels, play an important role in accurately delivering drugs to wounds, creating microenvironments for the adhesion and proliferation of support cells, and in tissue remodeling, repair, and wound healing. This article focuses on the study of SF protein-based soft materials, summarizing their preparation methods and basic applications, as well as their regenerative effects, such as drug delivery carriers in various aspects of tissue engineering such as bone, blood vessels, nerves, and skin in recent years, as well as their promoting effects on wound healing and repair processes. The authors expect SF soft materials to play an important role in the field of tissue repair.

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Sequential intervention of anti-inflammatory and osteogenesis with silk fibroin coated polyethylene terephthalate artificial ligaments for anterior cruciate ligament reconstruction

Abstract: Graft-host integration after anterior cruciate ligament (ACL) reconstruction sequentially follows the prognosis from inflammation period to regeneration period. However, due to the insufficient bioactivity, polyethylene terephthalate (PET) artificial ligaments often...

Cited by 3 publications

References 52 publications

A machine learning system for artificial ligaments with desired mechanical properties in ACL reconstruction applications

A machine learning system for artificial ligaments with desired mechanical properties in ACL reconstruction applications

Silk fibroin-based scaffolds for tissue engineering

The Application of Regenerated Silk Fibroin in Tissue Repair

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