Sequential injection spectrophotometric assay of bromazepam complexed with iron(II) in hydrochloric acid with chemometric optimization

Application of sequential injection analysis to pharmaceutical analysis

“…For example, Sultan et al developed a chemometric optimisation for the spectrophotometric determination of bromazepam complexed with iron(II) in hydrochloric acid [67]. In this proposal, the optimum operational conditions were determined, both for the system and for the chemical variables.…”

“…Sultan's research group, the first to describe a SIA method applied to the analysis of pharmaceutical products, proposed a series of methods for the determination of active ingredients in pharmaceutical formulations based on the complexation reactions of metallic ions with the active ingredients [67][68][69][70][71][72]. Trimeprazine and perphenazine were determined after complexation with palladium(II), in the presence of hydrochloric acid with spectrophotometric monitoring of the complexes formed at 515 nm in the case of trimeprazine and 560 nm for the deter- mination of perphenazine [70].…”

Sequential Injection Analysis for Optimization of Molecular Biology Reactions

“…While DOE has been used to efficiently optimize biochemical reactions before5, and has been used to optimize a SIA protocol6, 7 for a single analysis, an integrated, automated system for the optimization of molecular biology reactions has never before been developed. To the extent that our approach is successful, it should be possible to greatly expand its use.…”

“…12 The SIA system performs an experiment and reports the results to the algorithm which in turn makes a decision: either refine within the searched space, expand the search space, or stop. While DOE has been used to efficiently optimize biochemical reactions before 5 and has been used to optimize a SIA protocol 6,7 for a single analysis, an integrated, automated system for the optimization of molecular biology reactions has never before been developed. To the extent that our approach is successful, it should be possible to greatly expand its use.…”

Development of automatic methods for trace metals determination using on-line separation and preconcentration techniques coupled with atomic spectrometry

“…In analytical chemistry, multivariate techniques have been applied to the optimization of chemical factors during the development of analytical strategies, for instance, systems involve preconcentration using solid phase extraction Penteado et al, 2006;Tarley et al, 2005); liquid-liquid extraction (Baranda et al, 2005;Ebrahimzadeh et al, 2007) and coprecipitation (Saracoglu et al, 2006); some flow injection analysis methods (dos del Campo et al, 2006;) and sequential injection analysis (da Silva et al, 2004;Sultan et al, 1999;Gomez et al, 2006); Idris et al, 2006). Other applications include the optimization of instrumental parameters of equipment for analysis by graphite furnace atomic absorption spectrometry (ETAAS) (Pereira-Filho et al, 2002;, inductively coupled plasma optical emission spectrometry (ICP-AES) (Villaneuva et al, 2000;Trevizan et al, 2005) and inductively coupled plasma mass spectrometry (ICP-MS) (Woller et al, 1998).…”