Sequential injection analysis of captopril based on colorimetric and potentiometric detection

A simple spectrophotometric method for the determination of captopril in pharmaceutical preparations using ammonium molybdate

“…A UV spectrophotometric procedure has been used for the determination of CPT in bulk drug and tablets in the presence of iodine, where the indirect quantization of the product was carried at 351 nm [34] This method present low selectivity, as all unsaturated compounds display one or more bands in that region of the spectrum. The CPT has been determined in the area of the visible after the reaction with iodine [34], ferric chloride in presence of 2,2'-bipirydil [34] and potassium ferricyanide [35], Pd(II) [27,36,37], Co(II) in presence of 2,2'-dipyridil-2-pyridylhydrazone [38], N-(1-naphtyl) ethylenediamine in acid media (nitrous acid) [39], Folin-Ciocalteu reagent [40,41] and molybdophosphoric acid [42]. This last procedure can only be used for the determination of CPT in pure forms, because the presence of the most common excipients in pharmaceutical formulations (glucose, fructose, lactose, sucrose, starch) they interfere seriously in this method.…”

Automated Determination of Pharmaceutically and Biologically Active Thiols by Sequential Injection Analysis: A Review

“…Such methods are typically simple, easy to handle, with low operational costs and with satisfactory figures of merit for most quality control applications [19]. The main analytical figures of merit of spectrophotometric SI methods for the determination of thiols can be found in Table 1 [20][21][22][23][24][25][26][27].…”

A Novel Use of 3-Methyl-2-Benzothiazolinone Hydrazone Hydrochloride Monohydrate for Kinetic Spectrophotometric Determination of Captopril in Pharmaceutical Formulations

“…About 30% of the drug is bound to plasma protein [2][3]. In order to assure the quality of CPT containing pharmaceutical formulations, several analytical methods have been reported for its determination, including spectrophotometric [4][5][6][7][8][9], kinetic spectrophotometric methods [10][11][12][13], high performance liquid chromatography (HPLC) [14][15][16], polarography [17], stripping voltammetry [18][19], fluorimetry [20], atomic absorption spectrophotometry [21], flow injection analysis [22][23][24][25],and potentiometry [26].…”