Sequential healing at implants installed immediately into extraction sockets. An experimental study in dogs

Mainetti, Tomaso; Lang, Niklaus P.; Bengazi, Franco; Favero, Vittorio; Cantero, Luis Soto; Botticelli, Daniele

doi:10.1111/clr.12533

Cited by 17 publications

(23 citation statements)

References 21 publications

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“…Based on previous evidence, the influence of the following factors on osseointegration surrogate outcomes (%BA, %BIC) was analysed herein: defect morphology/dimensions (Polyzois et al, ; Schwarz et al, ), implant placement time (Mainetti et al, ), implant surface characteristics (Barfeie et al, ) and the use of membranes to contain the grafted sites (Chiapasco and Zaniboni, ; Lorenzoni et al, ). Only the timing of implant placement demonstrated a statistically significant effect on %BIC, with 11% greater BIC observed in implants placed in association with defects surgically created in healed sites compared with the BIC in immediate implants placed in large extraction sockets.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, the relatively small number of studies and large heterogeneity in the current meta‐analysis complicate the interpretation of this finding. In context, a recent study reported similar sequential healing patterns around implants placed in extraction sockets vs. healed sites in dogs, with no significant differences in BIC at early (1 week) or later (3 months) time points (Mainetti et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Bone tissue engineering in oral peri-implant defects in preclinicalin vivoresearch: A systematic review and meta-analysis

Shanbhag

Pandis

Mustafa

et al. 2017

J Tissue Eng Regen Med

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The regeneration and establishment of osseointegration within oral peri-implant bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous and/or biomaterial-based bone grafting. The objective of this systematic review was to answer the focused question: in animal models, do cell-based BTE strategies enhance bone regeneration and/or implant osseointegration in experimental peri-implant defects, compared with grafting with autogenous bone or only biomaterial scaffolds? Electronic databases were searched for controlled animal studies reporting on peri-implant defects and implantation of mesenchymal stem cells (MSC) or other cells seeded on biomaterial scaffolds, following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Random effects meta-analyses were performed for the outcomes histomorphometric bone area fraction (BA) and bone-to-implant contact (BIC). Nineteen studies reporting on large animal models (dogs and sheep) were included. Experimental defects were created surgically (16 studies) or via ligature-induced peri-implantitis (LIPI, three studies). In general, studies presented with an unclear to high risk of bias. In most studies, MSC were used in combination with alloplastic mineral phase or polymer scaffolds; no study directly compared cell-loaded scaffolds vs. autogenous bone. In three studies, cells were also modified by ex vivo gene transfer of osteoinductive factors. The meta-analyses indicated statistically significant benefits in favour of: (a) cell-loaded vs. cell-free scaffolds [weighted mean differences (WMD) of 10.73-12.30% BA and 11.77-15.15% BIC] in canine surgical defect and LIPI models; and (b) gene-modified vs. unmodified cells (WMD of 29.44% BA and 16.50% BIC) in canine LIPI models. Overall, heterogeneity in the meta-analyses was high (I 70-88%); considerable variation was observed among studies regarding the nature of cells and scaffolds used. In summary, bone regeneration and osseointegration in peri-implant defects are enhanced by the addition of osteogenic cells to biomaterial scaffolds. Although the direction of treatment outcome is clearly in favour of BTE strategies, due to the limited magnitude of treatment effect observed, no conclusive statements regarding the clinical benefit of such procedures for oral indications can yet be made. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bone tissue engineering in oral peri-implant defects in preclinicalin vivoresearch: A systematic review and meta-analysis

Shanbhag

Pandis

Mustafa

et al. 2017

J Tissue Eng Regen Med

View full text Add to dashboard Cite

show abstract

“…, ; Mainetti et al. , ), one at implants installed in the rabbit tibiae (Caneva et al. ), and two at implants installed in humans (Bosshardt et al.…”

Section: Methodsmentioning

confidence: 99%

“…Two studies included data from implants installed in either healed sites or extraction sockets (Mainetti et al. , ). In one of these studies, both implants were immediately loaded (Mainetti et al.…”

Section: Methodsmentioning

confidence: 99%