Sequential genetic and epigenetic alterations in human pluripotent stem cells for recurrent abnormality
Yun-Jeong Kim,
Byunghee Kang,
Solbi Kweon
et al.
Abstract:Human embryonic stem cells (hESCs) are naturally equipped to maintain genome integrity to minimize genetic mutations during early embryo development. However, genetic aberration risks and subsequent cellular changes in hESCs duringin vitroculture pose a significant threat to stem cell therapy. While a few studies have reported specific somatic mutations and copy number variations (CNVs), the molecular mechanisms underlying ‘culture-adapted phenotype’ acquisitions of hESCs are largely unknown. Therefore, we con… Show more
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