Sequential extraction of bioactive compounds from Melia azedarach L. in fixed bed extractor using CO2, ethanol and water

Bitencourt, Raphaela Gabrí; Queiroga, Carmen Lucia; Duarte, Gustavo Henrique Bueno; Eberlin, Marcos N.; Kohn, Luciana Konecny; Arns, Clarice Weis; Cabral, Fernando A.

doi:10.1016/j.supflu.2014.09.027

Cited by 22 publications

(18 citation statements)

References 41 publications

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“…The phenolic yields obtained were 63.4 g/kg, 38.8 g/kg and 68.0 g/kg of extract for SC-CO2 + 15% W, of extract for SC-CO2 + 15% EtOH, and Sc-CO2 + 15% W extraction, followed by SC-CO2 + 15% EtOH, respectively. This last procedure gave the highest phenolic yield In another study Porto et al [63] verified the effect of solvent (CO2) flow rate (4 and 6 kg/h CO2) on the extraction of total phenols from grape marc and verified that the mass transfer increases with the decrease in flow rate. This could be attributed to fact that the contact time between the solvent and the compounds to be extracted increased with the lower flow rate, thus affecting positively the extraction efficiency.…”

Section: Operative Conditionsmentioning

confidence: 83%

Supercritical fluid extraction of bioactive compounds

Silva

Rocha-Santos

Duarte

2016

TrAC Trends in Analytical Chemistry

490

219

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An ideal extraction method should be swift, yield quantitative recovery without degradation, and the extracts should be easily separated from the solvent. The development and application of alternative green technology to replace conventional extraction methods with improved extraction efficiency and low environmental impact for the determination of natural bioactive compounds is therefore, highly important. Supercritical fluid technology offers features that overcome many limitations of conventional extraction methods. This review presents an analytical overview regarding the application of supercritical fluids in the extraction of bioactive compounds and their operative extraction conditions, along with the investigation of further improvements on the extraction efficiency and the applied techniques for the structural characterization and identification of such bioactive compounds.

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Section: Operative Conditionsmentioning

confidence: 83%

Supercritical fluid extraction of bioactive compounds

Silva

Rocha-Santos

Duarte

2016

TrAC Trends in Analytical Chemistry

490

219

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“…Da Porto et al [ 108 ] indicated that the best results were obtained when the extraction was performed in sequential steps. Such studies were also performed by other groups of researchers [ 18 , 52 , 102 , 103 , 133 , 141 , 142 , 143 ]. The studies were aimed at the extraction of particular materials first with pure carbon dioxide, then the residue extraction with the mixture of ethanol and water and finally the residue extraction from step 2 with water.…”

Section: Separation Of Phenolic Compounds With Supercritical Co mentioning

confidence: 94%

The Application of Supercritical Fluid Extraction in Phenolic Compounds Isolation from Natural Plant Materials

2018

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The separation of phenolic compounds by supercritical fluid extraction has been widely studied throughout the last two decades. This is evidenced by a number of publications and articles. Supercritical fluid extraction (SFE) has become thus the effective method of separating the mentioned group of compounds. On the other hand, SFE is a beneficial approach in plant waste materials utilization and reduction of environmental burdens caused by the wastes. The aim of the study is to gather and systematize available information on the phenolic compounds separation that have been reported so far as well as to evaluate whether there is one optimal supercritical fluid extraction method for the phenolic compounds.

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“…It increased glucose-6-phosphate dehydrogenase activity and hepatic, skeletal muscle glycogen content, after 21 days of treatment. The study revealed the regeneration of insulin-producing cells and a corresponding increase in the plasma insulin and c-peptide levels with the treatment [ 60 ] Melia azedarach L. Mahaneem (S), Bakain (H), Persian lilac (E) Tree (W/C)/all parts Azedarachic acid ( 15 ), nicotinic acid, gallic acid, para-coumaric acid, vanillic acid, chlorogenic acid, syringic acid, caffeic acid, ferulic acid, fatty acids (caproic, palmitic, stearic, oleic, linoleic, and linolenic acid) [ 61 ] The decoction of aerial parts is taken in the morning (1) Bioassay-guided fractions and isolates of fruits and leaves showed inhibitory effects on protein tyrosine phosphatase-1B enzyme as well as glucose uptake stimulation on C 2 Cl 2 myoblasts cells in vitro [ 62 ] (2) Aqueous leaf extracts (300, and 400 mg/kg, intraperitoneal) displayed anti-diabetic on type 2 mice [ 63 ] Menispermaceae Cissampelos pareira L. Patha (S), midwife’s herb (E), Padi/Parh (L) Climber (W/C)/whole plant Pelosine, l -curine, hayatinine, hayatidine, cissampareine, cissamine, dicentrine, cycleanine, insularine, cycleanine, nuciferine, bulbocarpine, corytuberine, magniflorine, norimeluteine, pareitropone, berberine (8), reserpine [ 64 ] The dried root powder (half teaspoon) is taken with water once a day for 40 days The hydro-alcoholic leaves extract (200 and 400 mg/kg, p.o.) showed anti-diabetic activity by decreasing fasting blood glucose and increasing the body weight of on STZ-induced diabetic rats when compared to glibenclamide (5 mg/kg) [ 65 ] Stephania glabra (Roxb.)…”

Section: Resultsmentioning

confidence: 99%

Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region (Uttarakhand) Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

Kumar

Aswal

Chauhan

et al. 2019

Nat. Prod. Bioprospect.

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The Himalayan region is the treasure house of natural wealth, particularly of medicinal and aromatic plants. These plants are used by the Indian traditional healers for the past many centuries to treat various ailments such as skin disorders, asthma, diabetes, snake bite, fever, pain, eye diseases, diarrhoea, indigestion, jaundice, burn, wound, liver disorder, CNS disorders and urinary tract infection. The indigenous traditional knowledge of medicinal plants and therapies of various local communities has been lost due to changes in traditional culture and the introduction of modern technologies. Therefore, it is essential to explore the traditional knowledge of the indigenous medicinal plants mainly in such areas where there is a severe threat to natural vegetation owing to human inhabitation. The present study aimed to explore the medicinal plants of Chakrata region (Jaunsar–Bawar Hills), Uttarakhand, India used in the folk medicine for the management of diabetes by Jaunsari Tribe. In a comprehensive field survey, the information about the medicinal plants have been mainly collected from the traditional healers and other elderly people belong to the tribal community. All the information about the medicinal plants of the study area was documented in a field book. Various tools have been used to collect the samples for identification purpose and the authentication of the plants was done with the help of taxonomists. The literature on these plants was also searched from online (PubMed and Scopus) as well as from some textbooks and Ayurvedic classical texts. The present survey-based work described a total of 54 plants belonging to 47 genera and 30 families used in the traditional medicine for the management of diabetes in Chakrata region. The information gathered from the local community revealed that the plants are effective in diabetes and one can use most of them without consulting a practitioner or traditional healer. The literature revealed that most of the surveyed plants are already used in the preparation of various antidiabetic formulations such as Chandraprabha vati, Nishamalaki chunra, Amritamehari churna and Nisakathakadi kashayam along with various patent drugs which are frequently prescribed by the Ayurvedic practitioners in India. The present study explored the traditional as well as scientific knowledge on the antidiabetic plants used by the tribal community. The documented information on these plants can be further used by the scientific community to develop new drugs/formulations with the help of modern techniques.

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Sequential extraction of bioactive compounds from Melia azedarach L. in fixed bed extractor using CO2, ethanol and water

Cited by 22 publications

References 41 publications

Supercritical fluid extraction of bioactive compounds

Supercritical fluid extraction of bioactive compounds

The Application of Supercritical Fluid Extraction in Phenolic Compounds Isolation from Natural Plant Materials

Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region (Uttarakhand) Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

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