Sequential effects of photodynamic treatment of basal cell carcinoma

Abstract

We show a clear time-dependent profile of apoptotic markers and inflammatory infiltrate composition in SBCC after ALA-PDT. SBCC cells express cytokines and chemotactic molecules that are likely related to the recruitment of inflammatory cells.

Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma

“…Dermal leucocytic infiltration was a reproducible finding in the BCC post‐PDT, consistent with previous reports 11,12 . The direct demonstration of topical PDT‐induced reduction in Langerhans cells in human BCC undergoing treatment indicates a potentially negative cellular impact of PDT.…”

“…Dermal leucocytic infiltration was a reproducible finding in the BCC post-PDT, consistent with previous reports. 11,12 The direct demonstration of topical PDT-induced reduction in Langerhans cells in human BCC undergoing treatment indicates a potentially negative cellular impact of PDT. Langerhans cells are a pivotal component of the skin immune system, present-ing antigens and activating effector cells, including tumourspecific T cells which are believed to be important for tumour eradication.…”

A randomized clinical comparative study of cryotherapy plus photodynamic therapy vs. cryotherapy in the treatment of multiple condylomata acuminata

“…In addition, PDT has been shown to have some antiviral properties (18, 19). Another mechanism contributing to the efficacy of PDT might be the inflammatory response after PDT (20), which also contributes to the antiviral response.…”

Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations

“…Acute immune responses are confirmed in BCC patients treated with topical ALA-or MAL-PDT. Within 1 h after PDT, increased infiltration of neutrophils is already visible at the tumor site, reaching its peak at 4 h, and declining to basal level after 48 h [62]. Interestingly, activity of neutrophils, as indicated by chemiluminescence, was found upregulated in peripheral blood 4 h after PDT [63], indicating this acute immune response might not be restricted to the treated lesion.…”

“…Interestingly, activity of neutrophils, as indicated by chemiluminescence, was found upregulated in peripheral blood 4 h after PDT [63], indicating this acute immune response might not be restricted to the treated lesion. In addition, after 48-72 h myeloid cells such as macrophages and mast cells accumulate at the treated site [62]. Increased expression of immunostimulatory IL-23, IL-22, IL-17, and IFN-γ was found in peritumoral inflammatory cells shortly after PDT [64].…”