Sequential Dieckmann cyclization enables the total synthesis of 7-epi-clusianone and 18-hydroxy-7-epi-clusianone

Abstract

We established a protocol for constructing the core of polycyclic polyprenylated acylphloroglucines. This protocol facilitated the synthesis of 7-epi-clusianone, 18-hydroxy-7-epi-clusianone, and sampsonione P via a 6-membered intermediate.