Sequential delivery of synergistic drugs by silica nanocarriers for enhanced tumour treatment

Birault, Albane; Giret, Simon; Théron, Christophe; Gallud, Audrey; Silva, Afitz Da; Durand, Denis; Nguyen, Christophe; Bettache, Nadir; Gary‐Bobo, Magali; Bartlett, John R.; Man, Michel Wong Chi; Carcel, Carole

doi:10.1039/c9tb02225b

Cited by 7 publications

(6 citation statements)

References 29 publications

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“…Then a liver cancer cell line (HepG2) was also studied and data showed that SiNPs incubation induced 19% cell death and after pulsed laser stimulation, 43% cell death was quantified ( Figure 4 b). Finally, heathy cells (fibroblasts), already known to be less efficient to internalize nanoparticles, were incubated with SiNPs and irradiated ( Figure 4 c) [ 41 ]. Data demonstrated a decrease in living cells without light stimulus (27%), but interestingly, the laser excitation doesn’t induce any supplementary cell death (25%).…”

Section: Resultsmentioning

confidence: 99%

Biological Assessment of Laser-Synthesized Silicon Nanoparticles Effect in Two-Photon Photodynamic Therapy on Breast Cancer MCF-7 Cells

Al-Kattan

Ali

Daurat³

et al. 2020

Nanomaterials

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Driven by their distinctive physiological activities, biological properties and unique theranostic modalities, silicon nanoparticles (SiNPs) are one of the promising materials for the development of novel multifunctional nanoplatforms for biomedical applications. In this work, we assessed the possibility to use laser-synthesized Si NPs as photosensitizers in two-photon excited photodynamic therapy (TPE-PDT) modality. Herein, we used an easy strategy to synthesize ultraclean and monodispersed SiNPs using laser ablation and fragmentation sequences of silicon wafer in aqueous solution, which prevent any specific purification step. Structural analysis revealed the spherical shape of the nanoparticles with a narrow size distribution centered at the mean size diameter of 62 nm ± 0.42 nm, while the negative surface charge of −40 ± 0.3 mV ensured a great stability without sedimentation over a long period of time. In vitro studies on human cancer cell lines (breast and liver) and healthy cells revealed their low cytotoxicity without any light stimulus and their therapeutic potential under TPE-PDT mode at 900 nm with a promising cell death of 45% in case of MCF-7 breast cancer cells, as a consequence of intracellular reactive oxygen species release. Their luminescence emission inside the cells was clearly observed at UV-Vis region. Compared to Si nanoparticles synthesized via chemical routes, which are often linked to additional modules with photochemical and photobiological properties to boost photodynamic effect, laser-synthesized SiNPs exhibit promising intrinsic therapeutic and imaging properties to develop advanced strategy in nanomedicine field.

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Section: Resultsmentioning

confidence: 99%

Biological Assessment of Laser-Synthesized Silicon Nanoparticles Effect in Two-Photon Photodynamic Therapy on Breast Cancer MCF-7 Cells

Al-Kattan

Ali

Daurat³

et al. 2020

Nanomaterials

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“…DOX and MTX have also been co-delivered in dual response to pH and thermal stimuli [139]. In a recent study, a novel dual-functional block copolymer mPEG-b-poly(TAC-co-ATMC-g-S(CH 2 ) 10 COOH) was developed for the pH sensitive release of DOX and MTX [140]. Birault et al developed the pH responsive hybrid silica nanoparticle for sequential delivery of CPT and 5-fluorouracil (Figure 2) [141].…”

Section: Chemo-combinational Therapymentioning

confidence: 99%

Smart Nanoparticles for Chemo-Based Combinational Therapy

et al. 2021

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Cancer is a heterogeneous and complex disease. Traditional cancer therapy is associated with low therapeutic index, acquired resistance, and various adverse effects. With the increasing understanding of cancer biology and technology advancements, more strategies have been exploited to optimize the therapeutic outcomes. The rapid development and application of nanomedicine have motivated this progress. Combinational regimen, for instance, has become an indispensable approach for effective cancer treatment, including the combination of chemotherapeutic agents, chemo-energy, chemo-gene, chemo-small molecules, and chemo-immunology. Additionally, smart nanoplatforms that respond to external stimuli (such as light, temperature, ultrasound, and magnetic field), and/or to internal stimuli (such as changes in pH, enzymes, hypoxia, and redox) have been extensively investigated to improve precision therapy. Smart nanoplatforms for combinational therapy have demonstrated the potential to be the next generation cancer treatment regimen. This review aims to highlight the recent advances in smart combinational therapy.

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“…A first strategy involves the use of triazine derivatives as stalks and 5-fluorouracil-based compounds as caps, which are able to close the pore entrances thanks to hydrogen bonding interactions. However, at acid pH the interaction weakens and cytotoxic 5-fluorouracil is released along with a loaded cytotoxic, leading to high cytotoxicity [277]. Another strategy involves the use of biocompatible cyclodextrins (CD).…”

Section: Ph-operated Nanovalvesmentioning

confidence: 99%

“…Stalk + Cap Supramolecular structures that close and open the pores thanks to the interaction with stalks grafted on the surface [277][278][279][280][281]…”

Section: Ph-operated Nanovalvesmentioning

confidence: 99%

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Gisbert-Garzarán

Vallet‐Regí

2020

Nanomaterials

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Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

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Sequential delivery of synergistic drugs by silica nanocarriers for enhanced tumour treatment

Abstract: Environmentally-responsive nanocarriers exhibiting a synergistic effect, where pH-triggered release of the cytotoxic cap followed by diffusion-controlled release of the drug cargo led to essentially complete cell death.

Cited by 7 publications

References 29 publications

Biological Assessment of Laser-Synthesized Silicon Nanoparticles Effect in Two-Photon Photodynamic Therapy on Breast Cancer MCF-7 Cells

Biological Assessment of Laser-Synthesized Silicon Nanoparticles Effect in Two-Photon Photodynamic Therapy on Breast Cancer MCF-7 Cells

Smart Nanoparticles for Chemo-Based Combinational Therapy

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

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