Abstract:Local tumor ablation can be achieved by physical energy-based therapies, such as, irradiation, ultrasound, microwave and radiofrequency. Although tumor antigens released from ablated tumors could induce an anti-tumoral immunity, antigen presentation from ablated tumors are not efficient in inducing a strong systemic immunity. Recently, we demonstrated that immunopriming by LOFU, followed by hypofractionated radiation, reversed immunological tolerance of T cells in draining lymph nodes, induced systemic anti-tu… Show more
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