Sequential Changes of Plasma Proteins after Surgical Trauma

Abstract

Sequential changes of plasma proteins after surgical trauma. Scand. J . d i n . Lab. Invest. 29, suppl. 124, 127-136, 1972. The response of 18 plasma proteins after cholecystectomy has been followed up for 3 weeks. The acute phase reaction has been compared with that after mastectomy. The response to these tissue lesions were very similar but more intense after cholecystectorny. The finding suggest that aa-macroglobulin may be used as an internal standard since no apparent changes appear. The concentration decreases during the first few postoperative days for albumin, a-lipoproteins, transferrin and prealbumin. No common cause is probable. C-reactive protein and antichymotrypsin begin to rise within eight hours. One day later orosomucoid, fibrinogen, haptoglobin and a,-antitrypsin show a strong reaction. Hemopexin, /3,c-globulin, prothrombin, ceruloplasmin, Gc-globulin, a , easily precipitable glycoprotein, plcsminogen and cold insoluble globulin showed a delayed reaction with a moderate increase within a week. The immunoglobulins show insignificact changes. 4 types of operations (herniorrhaphy, appendectomy, thyroidectomy and gastrectomy) utilizing mainly the radial immunodiffusion technique Scand J Clin Lab Invest Downloaded from informahealthcare.com by University of Newcastle on 01/02/15 For personal use only. Scand J Clin Lab Invest Downloaded from informahealthcare.com by University of Newcastle on 01/02/15 For personal use only. * "% of normal" refers to the serum or plasma pool from healthy blood donors. Scand J Clin Lab Invest Downloaded from informahealthcare.com by University of Newcastle on 01/02/15 For personal use only. Scand J Clin Lab Invest Downloaded from informahealthcare.com by University of Newcastle on 01/02/15 For personal use only.

Pharmacokinetics of lidocaïne in children with congenital heart disease

“…22 Furthermore, previous studies have demonstrated that in both surgical and trauma patients the serum concentration of ctt-AGP does not increase until six to eight hours after skin incision. [23][24][25] We found no significant differences in the pharmacokinetic variables of lidocaine among the three groups of patients. The tlet and ttl3 in this study are in agreement with the results of previous studies.…”

To Study the Levels of C - Reactive Protein and Total Leucocyte Count in Patients Operated of Open and Laparoscopic Cholecystectomy

“…Although significant differences in post-operative WBC counts are observed, there is no significant correlation between it and serum CRP concentrations. Aronson et al, [8] have already established that leucocytes are not involved in the increased synthesis of APRP, as the same response was seen in patients with agranulocytosis.…”

“…CRP is very consistent in response and is, therefore, the most satisfactory single screening test for an "acute phase" reactant [5]. CRP is a component of normal serum [7], which rises more dramatically than any other protein after surgical trauma [8][9][10]11]. CRP begins to rise 4-12 h post-operatively, reaches the peak level after 24-72 h, and returns to normal after 2 weeks [8,12,13,14].…”

“…CRP is a component of normal serum [7], which rises more dramatically than any other protein after surgical trauma [8][9][10]11]. CRP begins to rise 4-12 h post-operatively, reaches the peak level after 24-72 h, and returns to normal after 2 weeks [8,12,13,14]. Hence, this study was done to quantify the difference in tissue damage between open cholecystectomy (OC) and laparoscopic cholecystectomy (LC).…”

Purified Human Plasma Proteins of Unknown Function

“…In recent investigations Travis et al (1978) also suppose that one of the primary functions of a1x could be inactivation of leukocyte cathepsin G. Therefore, it should play an important role in the early stage of inflammable processes, since a2-macroglobulin is not able to penetrate into the extravasal space because of the high molecular weight. This assumption is also supported by the fact that the serum concentration of a1x can, in the beginning of the acute stage of many diseases with leukocyte proliferation, increase up to the quadruple of the normal value within 8 hr (Aronson et al, 1972).…”