Sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine following partial thyroidectomy for nontoxic nodular goiter

Shigemasa, Chiaki; Adachi, Toshiaki; Igawa, Osamu; Taniguchi, Shin‐ichi; Mitani, Yasuo; Ueta, Yoshihiko; Hori, Shinya; Yoshïda, Akio; Yamauchi, Norihiro; Mashiba, Hiroto

doi:10.1016/0026-0495(88)90090-x

Cited by 8 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgical manipulation of thyroid gland has been demonstrated to sharply increase sTg during thyroid surgery 11–13. Indeed, the mechanical trauma induces massive release of sTg into the bloodstream 11–13. Intraoperative sTg levels seem to correlate with the extent of gland damage and resection 12, 13.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, the mechanical trauma induces massive release of sTg into the bloodstream 11–13. Intraoperative sTg levels seem to correlate with the extent of gland damage and resection 12, 13. Thus, we chose to monitor intraoperative and postoperative sTg as an indicator of thyroid gland manipulation.…”

Section: Discussionmentioning

confidence: 99%

“…Serum thyroglobulin (sTg) levels were measured to evaluate thyroid manipulation. Mechanical trauma during thyroid surgery induces massive release of sTg, and its levels seem to correlate with the extension of thyroid tissue damage 11–13. C‐reactive protein (CRP) levels and white blood cell count were monitored to assess inflammatory and biologic response to surgical stress 14, 15.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Safety of video-assisted thyroidectomy versus conventional surgery

et al. 2004

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Safety of video-assisted thyroidectomy versus conventional surgery

et al. 2004

View full text Add to dashboard Cite

show abstract

“…It is known that TG is released into the systemic circulation from the thyroid follicules after trauma. Procedures such as open palpation, 20 thyroidectomy, 20,[34][35][36] diathermy, 20 RAI therapy 37 and biopsy might cause TG increment. 14,20,36 FNB is judged as a minor insult to thyroid tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Procedures such as open palpation, 20 thyroidectomy, 20,[34][35][36] diathermy, 20 RAI therapy 37 and biopsy might cause TG increment. 14,20,36 FNB is judged as a minor insult to thyroid tissue. 21 There are quite a lot of studies evaluating serum TG change after FNB of thyroid nodules and it was reported to increase in 33%-88% of patients with meanly ranging from 35% to 341% and reaching 12 500% after FNB in these studies.…”

Section: Discussionmentioning

confidence: 99%

The value of serum thyroglobulin alteration after ultrasonography‐guided fine‐needle biopsy of suspicious cervical lymph nodes in the diagnosis of metastasis in patients with differentiated thyroid cancer

et al. 2021

View full text Add to dashboard Cite

Background: It is known that serum thyroglobulin (TG) can increase after fine-needle biopsy of thyroid nodules. We aimed to determine whether TG is increased after ultrasonography (US)-guided fine needle capillary biopsy (FNC) of suspicious cervical lymph nodes (LNs) in thyroidectomised patients and investigate the possible association between change in TG and cytology results.Material and Methods: Data of 188 patients who underwent FNC of suspicious cervical LNs were retrospectively evaluated. Demographical, laboratory and ultrasonography features of LNs were noted. TG levels before FNC (TG b-FNC ), after FNC (TG a-FNC ), TG a-FNC /TG b-FNC ratio and the number of patients with increased TG were determined. Patients were grouped as benign, nondiagnostic, suspicious for malignancy and malignant according to the cytological results.Results: TG a-FNC , TG b-FNC /TG a-FNC and rate of patients with increased TG were significantly higher in malignant cytology group than other groups (P < .001). The optimal cut-off level of TG increase that was predictive for malignancy was 7.6% with a sensitivity of 73.7% and specificity of 85.2%. TG increase was not associated with age, sex, Thyroid-stimulating hormone (TSH) level, anti-TG positivity and US features of LNs while significantly lower in patients who received radioactive iodine (RAI) treatment. Among 31 patients with positive anti-TG, TG b-FNC /TG a-FNC , and rate of patients with increased TG were higher in malignant compared to benign and nondiagnostic cytology groups.Conclusions: Serum TG increment and rate of patients with increased TG after FNC of suspicious cervical LNs were higher in patients with malignant cytology than with all other cytology results both in all study group and in sub-group of anti-TG positive patients. Increase in TG after FNC might be an additional tool for determining LN metastasis.

show abstract

Disappearance of thyroid-stimulation blocking antibody by glucocorticoid therapy in a patient with primary myxedema who developed aortitis syndrome during L-thyroxine supplementation

Shigemasa

Kouchi

Taniguchi

et al. 1990

J Endocrinol Invest

View full text Add to dashboard Cite

A 39-year-old woman with primary myxedema, who had the potent activities of thyrotropin-binding inhibitory immunoglobulins (TBII) and thyroid-stimulation blocking antibodies (TSBAb), developed aortitis syndrome about 6 months after the initiation of L-thyroxine (L-T4) supplementation. A 35 mg daily dose of prednisolone for aortitis syndrome was initiated, and the dose was gradually reduced. TBII and TSBAb activities were gradually decreased, and both reached normal levels (7.7% and 10.1%, respectively) 3 months after the initiation of prednisolone. Therefore, dose of L-T4 was gradually reduced, and L-T4 supplementation was stopped. Subsequently, however, recurrence of hypothyroidism was not observed. These observations indicate the possibility that hypothyroidism remits with disappearance of TBII and TSBAb activities in not only neonatal cases but also adult cases.

show abstract

Sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine following partial thyroidectomy for nontoxic nodular goiter

Cited by 8 publications

References 17 publications

Safety of video-assisted thyroidectomy versus conventional surgery

Safety of video-assisted thyroidectomy versus conventional surgery

The value of serum thyroglobulin alteration after ultrasonography‐guided fine‐needle biopsy of suspicious cervical lymph nodes in the diagnosis of metastasis in patients with differentiated thyroid cancer

Disappearance of thyroid-stimulation blocking antibody by glucocorticoid therapy in a patient with primary myxedema who developed aortitis syndrome during L-thyroxine supplementation

Contact Info

Product

Resources

About