Sequential change of asymmetric dimethylarginine levels after initiation of peritoneal dialysis in patients with end‐stage renal disease

Abstract

The findings of our study suggest that nPCR might influence the change of ADMA levels after initiation of CAPD.

Dimethylarginines ADMA and SDMA: The Real Water-Soluble Small Toxins?

“…The latter hypothesis is supported by the observation that in CKD5 patients on peritoneal dialysis, the increased protein catabolic rate is correlated with increased levels of ADMA. 4 Because ADMA was found to be increased in endstage renal disease patients, renal excretion of ADMA was considered to be the main route of elimination. 5 However, an early study in rabbits showed renal excretion not to be the major route for ADMA elimination, suggesting the presence of a catabolic pathway.…”