Sequential cellular and humoral responses in the abomasal mucosa and blood of Romney sheep dosed with Trichostrongylus axei

Pfeffer, A.; Douch, P.G.C.; Shaw, R.J.; Gatehouse, T.K.; Rabel, B.; Green, R.S.; Shirer, C.L.; Jonas, Wenke; Bisset, S.A.

doi:10.1016/0020-7519(96)00052-5

Cited by 41 publications

(19 citation statements)

References 24 publications

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“…sheep and human galectin 1 share 87% amino acid identity, rat and human galectin 7 share 73% nucleotide identity, and human and rat galectin 1 share 62% nucleotide identity). 2 This program is available via the World Wide Web. a These identities are probably over-estimates of the total nucleotide identity given that the partial galectin 10 clones used in the comparison correspond to the highly conserved CRD.…”

Section: Resultsmentioning

confidence: 99%

“…A eukaryotic transmembrane domain prediction program (TM predict) 2 indicates that the protein does not span a membrane. A putative protein kinase C phosphorylation site (position 120; SVK), two putative casein kinase II phosphorylation sites (positions 65 and 133; TFTD and TSVD, respectively), and a cell attachment sequence (position 127; RGD) have been recognized by a PROSITE data base search (see Fig.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Isolation and Characterization of a Novel Inducible Mammalian Galectin

Dunphy¹,

Balic²,

Barcham³

et al. 2000

Journal of Biological Chemistry

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Isolation and Characterization of a Novel Inducible Mammalian Galectin

Dunphy¹,

Balic²,

Barcham³

et al. 2000

Journal of Biological Chemistry

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“…It has been confirmed that both mast cells and intraepithelial mucosal mast cells (globule leucocytes) are present in substantial numbers in abomasal tissue niches of hypersensitized and relatively resistant animals. Additionally, mucosal tissue eosinophilia, increased mucus production and the Evaluation of resistance status of small ruminants presence of inhibitory substances in the mucus have been consistently observed in relation to the development of immunity to GINs in ruminants (Huntley et al, 1984 andPfeffer et al, 1996;Harrison et al, 1999;Balic et al, 2000b;Bricarello et al, 2004). Differences in cellular counts in resistant and susceptible individuals/breeds and their possible role as parameters are summarized in the following.…”

Section: Abomasal Histologymentioning

confidence: 96%

“…The level of immunoglobulins may also be helpful in determining the resistance and/or the tolerance potential of the host against GINs as infection involves the production of parasitespecific immunoglobulins such as IgA, IgG1 and IgE (Pfeffer et al, 1996;Harrison et al, 1999 andGill et al, 2000;Huntley et al, 2001;Strain and Stear, 2001) and these are powerful aids to verify the results of other practiced phenotypic parameters. Stear et al (1995) reported a strong correlation between immunoglobulins and worm burden in a study carried out on Rhö n sheep.…”

Section: Immunological Parametersmentioning

confidence: 99%

Markers/parameters for the evaluation of natural resistance status of small ruminants against gastrointestinal nematodes

Saddiqi¹,

Sarwar

Iqbal

et al. 2012

Animal

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The high prevalence of anthelmintic-resistant gastrointestinal nematodes (GINs) throughout the world has led to the need for alternative worm control strategies. One of the possible substitutes to reduce the problems of drug resistance and residue is the evaluation/breeding of small ruminants for greater resistance to the GINs (organically produced), which in turn would be a helpful tool to predict the performance of an animal. At present, the existing diversity in the genetic potential to resist/tolerate GINs infection both within and between breeds has been validated. Successful selection of animals to define the genotype and identified resistance is related to the employed markers. A number of phenotypic traits such as faecal egg count (FEC), worm burden, serum antibodies, peripheral eosinophilia, packed cell volume, live weight, serum protein and albumin concentrations have been used for this purpose both in natural and artificial infections. Relatively resistant/tolerant animals have also been found to have mastocytosis, globule leucocytes, high levels of histamine and immunoglobulin (Ig) A and IgE concentrations. Of these traits, the principal and most practical measurement used to assess resistance status in animals undergoing similar parasite challenges is FEC. FEC has a positive/negative correlation with other biochemical, cellular and immunological parameters; however, the reliability of individual trial is often questioned and valuable information regarding the genetic makeup can be obtained from pooled data of a large number of trials and parameters. This paper covers all the aspects reported in the literature on various parameters considered to evaluate the resistance status of a range of small ruminant breeds.

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“…Thus genetic resistance is immunogically mediated by proliferation of mucosal mast cells, globule leukocytes and eosinophils (Meeusen et al, 2005). The response against gastrointestinal nematodes also involves production of parasite-specific immunoglobulin A (IgA), IgG1 and IgE (Pfeffer et al, 1996;Kooyman et al, 1997;Shaw et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus

Bambou¹,

Chevrotière²,

Varo³

et al. 2008

Veterinary Parasitology

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The objective of this study was to evaluate the relationship of parasite-specific serum antibodies with the resistance status of Creole kids. The average breeding values on egg output predicted in a context of natural infection at 11 months of age were distant of 1.07 genetic standard deviation between resistant and susceptible animals. After drenching the animals were maintained worm-free during 1 month until experimental infection with 10,000 Haemonchus contortus infective larvae (L3). Enzyme-linked immunosorbent assay was carried out in serum samples to determine the level of IgG, IgA and IgE anti-H. contortus L3 crude extracts and adult excretion/secretion products (ESP). Parasitological and blood immunological parameters were measured on the 2 extreme groups. Despite the absence of any typical signs of haemonchosis, susceptible kids had more than 11 times higher faecal egg counts (FEC) at 35 days post-infection (d.p.i.) than resistant kids had. Levels of immunoglobulin against H. contortus L3 and ESP increased significantly after infection in both groups. However, no difference in the host immune response mediated by immunoglobulin against H. contortus was evidenced between groups. This finding suggests that, in goats previously infected by H. contortus, a degree of protection occurred and the phenotypic and genetic segregation in resistant and susceptible animals were not related to the humoral immune response. The correlation coefficients between FEC and IgE anti-ESP (r = 0.593; P < 0.05 was significant in both resistant and susceptible animals. Such correlation suggesting a hypersensitivity reaction dependent on worm prolificacy has never been described. This result needs further studies to understand the mechanisms underlying this observation. #

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Sequential cellular and humoral responses in the abomasal mucosa and blood of Romney sheep dosed with Trichostrongylus axei

Cited by 41 publications

References 24 publications

Isolation and Characterization of a Novel Inducible Mammalian Galectin

Isolation and Characterization of a Novel Inducible Mammalian Galectin

Markers/parameters for the evaluation of natural resistance status of small ruminants against gastrointestinal nematodes

Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus

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