Sequential antimicrobial treatment with linezolid for neurosurgical infections: efficacy, safety and cost study

Martín-Gandul, Cecilia; Mayorga-Buiza, María José; Castillo-Ojeda, Esperanza; Gómez-Gómez, M; Rivero-Garvía, Mónica; Gil-Navarro, MV; Márquez-Rivas, Javier; Me, Jiménez-Mejías

doi:10.1007/s00701-016-2915-0

Cited by 3 publications

(3 citation statements)

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“…Seventy-two (93.5%) patients were cured at the end of treatment. [16] In the present study, patients 8 and 9 received oral linezolid for 14 and 28 days and were cured without recurrence.…”

Section: Discussionmentioning

confidence: 65%

“…Postneurosurgical infection (PNSI) is a major problem and frequently requiring high dose and prolonged antibiotic therapy. [16] Methicillin-resistant Staphylococcus (MRS) is the major Gram-positive organism causing PNSI and its incidence is increasing. Vancomycin is considered the treatment of choice in MRS PNSI; however, it has limited penetration into the cerebrospinal fluid (CSF) that depends on both the integrity of the blood–brain barrier and the inflammatory meningeal status.…”

Section: Introductionmentioning

confidence: 99%

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Linezolid for the treatment of postneurosurgical infection caused by methicillin-resistant Staphylococcus

Rebai

Fitouhi

Daghmouri

et al. 2019

Surgical Neurology International

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Background:Postneurosurgical infection (PNSI) is a major problem. Linezolid is a bacteriostatic oxazolidinone antibiotic with a highly activity against Gram-positive cocci resistant to methicillin and a good cerebrospinal fluid penetration. The purpose of this study is to evaluate the efficacy of linezolid in the treatment of PNSI caused by methicillin-resistant Staphylococcus (MRS).Methods:We conducted an observational study for all patients over 14 years old and diagnosed with MRS PNSI. Demographic, clinical, and laboratory information were collected prospectively.Results:A total of 10 patients with PNSI (6 meningitis, 2 ventriculitis, and 2 subdural empyema) received linezolid. MRS isolated was Staphylococcus aureus in seven cases and Staphylococcus epidermidis in three cases. All isolated microorganisms were susceptible to vancomycin (minimum inhibitory concentration (MIC) = 2 mg/L) and linezolid (MIC = 1). The rate of microbiologic efficacy was 100% for patients with meningitis or ventriculitis. In the case of subdural empyema, focal infection had improved between 14 and 18 days. No adverse effects occurred during this study.Conclusion:Our results suggest that linezolid as an alternative to vancomycin for the treatment of PNSI caused by MRS with a high rate of efficacy.

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“…Seventy-two (93.5%) patients were cured at the end of treatment. [16] In the present study, patients 8 and 9 received oral linezolid for 14 and 28 days and were cured without recurrence.…”

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Linezolid for the treatment of postneurosurgical infection caused by methicillin-resistant Staphylococcus

Rebai

Fitouhi

Daghmouri

et al. 2019

Surgical Neurology International

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“…S. epidermidis is among the normal sinonasal flora, and it is commonly isolated from intracranial infections. 8 9 10 Blood and CSF cultures were negative. The patient was started on intravenous vancomycin and cefepime postoperatively, based on recommendations derived from consultation with infectious disease specialty.…”

Section: Case Reportmentioning

confidence: 99%

Pituitary Abscess: A Rare Clinical Entity in the Presence of Acute Rhinosinusitis: A Case Report

2018

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A pituitary abscess is an often-overlooked diagnosis in the clinical presentation of a sellar mass. Due to its rare incidence and nonspecific presentation, diagnosis and treatment is often delayed. The authors describe a 56-year-old male patient presenting with acute onset of severe headache, visual field deficit, and radiologic findings of an expansile sellar lesion. The presenting symptoms were unremarkable for the diagnosis of meningitis, cavernous sinus thrombosis, and septicemia. Recent medical history included symptoms of rhinosinusitis on the days preceding his acute presentation. The initial clinical presentation was suggestive of a possible pituitary apoplexy. Intraoperative findings revealed purulent output upon surgical entry of the sella. Histopathology confirmed the diagnosis of a pituitary abscess. Review of the clinical and radiologic data revealed evidence of multiple opacifications within the paranasal sinuses, along with dehiscence overlying the sellar bone, supporting a diagnosis of secondary pituitary abscess. This case, along with a review of the available literature, will serve to expand our knowledge of this rare disease process that is often overlooked. Clinicians should be mindful of this condition, and include a primary versus secondary pituitary abscess in the differential workup on such cases.

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Linezolid for therapy of Staphylococcus aureus meningitis: a cohort study of 26 patients

Pintado

Pazos

et al. 2020

Infectious Diseases

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Sequential antimicrobial treatment with linezolid for neurosurgical infections: efficacy, safety and cost study

Abstract: SAT with linezolid was safe and effective for the treatment of NSI. SAT reduces hospitalisation times, which means significant savings of health and economic resources.

Cited by 3 publications

References 32 publications

Linezolid for the treatment of postneurosurgical infection caused by methicillin-resistant Staphylococcus

Linezolid for the treatment of postneurosurgical infection caused by methicillin-resistant Staphylococcus

Pituitary Abscess: A Rare Clinical Entity in the Presence of Acute Rhinosinusitis: A Case Report

Linezolid for therapy of Staphylococcus aureus meningitis: a cohort study of 26 patients

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