Sequential and Simultaneous 4-Antenna Microwave Ablation in an Ex Vivo Bovine Liver Model

Zhang, Tianqi; Huang, Senmiao; Gu, Yeunhwa; Jiang, Xiongying; Huang, Zijing; Deng, Han-Xia; Huang, Jinhua

doi:10.1007/s00270-019-02241-6

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…However, extensive distances between the applicators (> 10 cm) led to insufficient ablations around the respective applicator. Similar results have been described for simultaneous multi-antenna microwave ablation (MWA) 17,18 . Incomplete ablations with indentations were observed when spacing between a total of three antennas exceeded 20 mm 18 .…”

Section: Discussionsupporting

confidence: 79%

“…In regard to local tumour control, mbRFA is even considered superior to other minimally invasive therapies such as MWA used for treating HCC ≤ 5 cm 30 . However, large and more confluent ablations have also been described in experimental studies for MWA using multiple antennas simultaneously 17 . Therefore, direct comparison of clinical efficacy between mbRFA and simultaneous multi-antenna MWA seems relevant to further improve ablative therapy options for HCC.…”

Section: Discussionmentioning

confidence: 99%

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Influence of interapplicator distance on multibipolar radiofrequency ablation during physiological and interrupted liver perfusion in an in vivo porcine model

Poch

Neizert

Geyer

et al. 2020

Sci Rep

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Radiofrequency ablation (RFA) is a curative treatment option for early stage hepatocellular carcinoma (HCC). Vascular inflow occlusion to the liver (Pringle manoeuvre) and multibipolar RFA (mbRFA) represent possibilities to generate large ablations. This study evaluated the impact of different interapplicator distances and a Pringle manoeuvre on ablation area and geometry of mbRFA. 24 mbRFA were planned in porcine livers in vivo. Test series with continuous blood flow had an interapplicator distance of 20 mm and 15 mm, respectively. For a Pringle manoeuvre, interapplicator distance was predefined at 20 mm. After liver dissection, ablation area and geometry were analysed macroscopically and histologically. Confluent and homogenous ablations could be achieved with a Pringle manoeuvre and an interapplicator distance of 15 mm with sustained hepatic blood flow. Ablation geometry was inhomogeneous with an applicator distance of 20 mm with physiological liver perfusion. A Pringle manoeuvre led to a fourfold increase in ablation area in comparison to sustained hepatic blood flow (p < 0.001). Interapplicator distance affects ablation geometry of mbRFA. Strict adherence to the planned applicator distance is advisable under continuous blood flow. The application of a Pringle manoeuvre should be considered when compliance with the interapplicator distance cannot be guaranteed.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Influence of interapplicator distance on multibipolar radiofrequency ablation during physiological and interrupted liver perfusion in an in vivo porcine model

Poch

Neizert

Geyer

et al. 2020

Sci Rep

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“…Furthermore, tissue changes caused by thermal delivery, such as charring and desiccation also modify electrical resistance in tissue, thus possibly further hindering the expansion of the ablation zone. The high electrical resistance within ventilated lung parenchyma and the ablation-induced tissue inhomogeneity make the expansion of the ablation zone particularly reliant on thermal conduction, especially at its periphery [10,21,22]. Within current clinical practice of MWA in the liver, to overcome the issue of limited sphericity, multiples antennas have been used to shape the ablation zone to create nearly spherical ablation zones.…”

Section: Discussionmentioning

confidence: 99%

Lung microwave ablation – an in vivo swine tumor model experiment to evaluate ablation zones

Prud’homme

Tériitéhau

Adam

et al. 2020

International Journal of Hyperthermia

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Purpose: To evaluate microwave ablation (MWA) algorithms, comparing pulsed and continuous mode in an in vivo lung tumor mimic model Materials and methods: A total of 43 lung tumor-mimic models of 1, 2 or 3 cm were created in 11 pigs through an intra-pulmonary injection of contrast-enriched minced muscle. Tumors were ablated under fluoroscopic and 3D-CBCT-guidance using a single microwave antenna. Continuous (CM) and pulsed mode (PM) were used. According to tumor size, 3 different algorithms for both continuous and pulsed mode were used. The ablation zones were measured using post-procedural 3D-CBCT and on pathologic specimens. Results: Two radiologists measured the ablation zones on CBCT and they significantly correlated with macroscopic and microscopic pathological findings: r ¼ 0.75 and 0.74 respectively (p < 0.0001) (interobserver correlation r ¼ 0.9). For 1, 2 and 3 cm tumors mimics lesions (TMLs), mean maximal and transverse ablation diameters were 3.6 6 0.3 Â 2.2 6 0.3 cm; 4.1 6 0.5 Â 2.6 6 0.3 cm and 4.8 6 0.3 Â 3.2 6 0.3 cm respectively using CM; And, 3.0 6 0.2 Â 2.1 6 0.2 cm; 4.0 6 0.4 Â 2.7 6 0.4 cm and 4.6 6 0.4 Â 3.2 6 0.4 cm respectively for PM, without any significant difference except for 1 cm TMLs treated by PM ablation which were significantly smaller (p ¼ 0.009) The sphericity index was 1.6, 1.6, 1.5 and 1.4, 1.5, 1.4 at 1, 2 and 3 cm for CM and PM respectively, p ¼ 0.07, 0.14 and 0.13 for 1, 2 and 3 cm tumors mimics. Conclusion: Microwave ablation for 1-3 cm lung tumors were successfully realized but with a moderate reproducibility rate, using either CM or PM. Immediate post ablation CBCT can accurately evaluate ablation zones.

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“…It should be noted that results from clinical trials were not included in this review. If one is looking for information about the clinical performance and trials related to MWA, several detailed reports, for example [49][50][51][52][53][54][55][56][57], are available.…”

Section: Introductionmentioning

confidence: 99%

A review of antenna designs for percutaneous microwave ablation

et al. 2021

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Microwave (MW) antenna is a key element in microwave ablation (MWA) treatments as the means that energy is delivered in a focused manner to the tumor and its surrounding area. The energy delivered results in a rise in temperature to a lethal level, resulting in cell death in the ablation zone. The delivery of energy and hence the success of MWA is closely dependent on the structure of the antennas. Therefore, three design criteria, such as expected ablation zone pattern, efficiency of energy delivery, and minimization of the diameter of the antennas have been the focus along the evolution of the MW antenna. To further improve the performance of MWA in the treatment of various tumors through inventing novel antennas, this article reviews the state-of-the-art and summarizes the development of MW antenna designs regarding the three design criteria.

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Sequential and Simultaneous 4-Antenna Microwave Ablation in an Ex Vivo Bovine Liver Model

Cited by 6 publications

References 25 publications

Influence of interapplicator distance on multibipolar radiofrequency ablation during physiological and interrupted liver perfusion in an in vivo porcine model

Influence of interapplicator distance on multibipolar radiofrequency ablation during physiological and interrupted liver perfusion in an in vivo porcine model

Lung microwave ablation – an in vivo swine tumor model experiment to evaluate ablation zones

A review of antenna designs for percutaneous microwave ablation

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